Enantioselective synthesis of coumarins catalyzed by an isosteviol‐derived tertiary amine‐squaramide catalyst

Chirality ◽  
2021 ◽  
Author(s):  
Zhiwei Ma ◽  
Chuanchuan Wang ◽  
Xiaofeng Liu ◽  
Xiaopei Chen ◽  
Jingchao Tao ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Enantioselective Synthesis

Enantioselective synthesis of multifunctionalized 4H-pyran derivatives using bifunctional thiourea-tertiary amine catalysts

2009 ◽  
Vol 20 (9) ◽  
pp. 1046-1051 ◽  
Author(s):  
Sheng-Li Zhao ◽  
Chang-Wu Zheng ◽  
Gang Zhao
Keyword(s):  
Tertiary Amine ◽  
Enantioselective Synthesis ◽  
Amine Catalysts

scholarly journals Enantioselective synthesis of 2,3-disubstituted trans-2,3-dihydrobenzofurans using a Brønsted base/thiourea bifunctional catalyst

2016 ◽  
Vol 14 (30) ◽  
pp. 7268-7274 ◽  
Author(s):  
Diego-Javier Barrios Antúnez ◽  
Mark D. Greenhalgh ◽  
Charlene Fallan ◽  
Alexandra M. Z. Slawin ◽  
Andrew D. Smith
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Bifunctional Catalyst ◽  
Enantioselective Synthesis ◽  
Brønsted Base

The enantioselective synthesis of 2,3-disubstituted trans-2,3-dihydrobenzofuran derivatives via intramolecular Michael addition has been developed using a bifunctional tertiary amine–thiourea catalyst.

Sequential Au(i)/chiral tertiary amine catalysis: a tandem C–H functionalization of anisoles or a thiophene/asymmetric Michael addition sequence to quaternary oxindoles

2016 ◽  
Vol 52 (12) ◽  
pp. 2537-2540 ◽  
Author(s):  
Zhong-Yan Cao ◽  
Yu-Lei Zhao ◽  
Jian Zhou
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Enantioselective Synthesis ◽  
Asymmetric Michael Addition ◽  
Amine Catalysis

We report an unprecedented sequential Au(i)/bifunctional tertiary amine catalysis, which enables a tandem C–H functionalization of weak nucleophiles (anisoles or thiophenes) and asymmetric Michael addition for the highly enantioselective synthesis of quaternary oxindoles.

ChemInform Abstract: Enantioselective Synthesis of Multifunctionalized 4H-Pyran Derivatives Using Bifunctional Thiourea-tertiary Amine Catalysts.

ChemInform ◽  
2009 ◽  
Vol 40 (42) ◽  
Author(s):  
Sheng-Li Zhao ◽  
Chang-Wu Zheng ◽  
Gang Zhao
Keyword(s):  
Tertiary Amine ◽  
Enantioselective Synthesis ◽  
Amine Catalysts

Catalytic enantioselective synthesis of indolizino[8,7-b]indole alkaloid derivatives based on the tandem reaction of tertiary enamides

2021 ◽  
Author(s):  
Xin-Ming Xu ◽  
Ming Xie ◽  
Jiazhu Li ◽  
Mei-Xiang Wang
Keyword(s):  
Indole Alkaloid ◽  
Enantioselective Synthesis ◽  
High Yield ◽  
Tandem Reaction ◽  
Indole Derivatives

An exquisite Pybox/Cu(OTf)2-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-b]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.

Pd-Catalyzed Enantioselective Synthesis of 4-Vinylimidazolidin-2-ones

Synfacts ◽  
2018 ◽  
Vol 14 (07) ◽  
pp. 0719
Keyword(s):  
Enantioselective Synthesis

Enantioselective Synthesis of Cyclopentenes via β-Azolium Ylides

Synfacts ◽  
2018 ◽  
Vol 14 (09) ◽  
pp. 0983
Keyword(s):  
Enantioselective Synthesis

Enantioselective Synthesis of Azamerone

2018 ◽  
Author(s):  
Matthew L. Landry ◽  
Grace McKenna ◽  
Noah Burns
Keyword(s):  
Late Stage ◽  
Cross Coupling ◽  
Enantioselective Synthesis ◽  
Selective Synthesis

A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade.

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids

2019 ◽  
Author(s):  
Ming Shang ◽  
Karla S. Feu ◽  
Julien C. Vantourout ◽  
Lisa M. Barton ◽  
Heather L. Osswald ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Heterocyclic Compounds ◽  
Cross Coupling ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Carbon Centers ◽  
Drug Candidates ◽  
Rapid Diversification ◽  
Directing Group ◽  
Compound Series

<div> <div> <div> <p>The union of two powerful transformations, directed C–H activation and decarboxylative cross-coupling, for the enantioselective synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described. Starting from simple carboxylic acid building blocks, this modular sequence exploits the residual directing group to access more than 50 scaffolds that would be otherwise extremely difficult to prepare. The tactical use of these two transformations accomplishes a formal vicinal difunctionalization of carbon centers in a way that is modular and thus amenable to rapid diversity incorporation. A simplification of routes to known preclinical drug candidates is presented along with the rapid diversification of an antimalarial compound series. </p> </div> </div> </div>

Enantioselective Synthesis of Azamerone

2018 ◽  
Author(s):  
Matthew L. Landry ◽  
Grace McKenna ◽  
Noah Burns
Keyword(s):  
Late Stage ◽  
Cross Coupling ◽  
Enantioselective Synthesis ◽  
Selective Synthesis

A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade.

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