Divergent Syntheses of Pyridoacridine Alkaloids via Palladium‐Catalyzed Reductive Cyclization with Nitro‐Biarenes

2021 ◽  
Author(s):  
Bo Liu ◽  
Shuping Wang ◽  
Changhao Bian ◽  
Hongze Liao ◽  
Hou‐Wen Lin
Keyword(s):  
Reductive Cyclization ◽  
Palladium Catalyzed ◽  
Pyridoacridine Alkaloids

Versatile Synthesis of 3-Arylindan-1-ones by Palladium-Catalyzed Intramolecular Reductive Cyclization of Bromochalcones.

ChemInform ◽  
2005 ◽  
Vol 36 (28) ◽  
Author(s):  
Ask Pueschl ◽  
Hans Christian Rudbeck ◽  
Andre Faldt ◽  
Allesia Confante ◽  
Jan Kehler
Keyword(s):  
Reductive Cyclization ◽  
Palladium Catalyzed

Recent Advances in Piperazine Synthesis

Synthesis ◽  
2017 ◽  
Vol 49 (12) ◽  
pp. 2589-2604 ◽  
Author(s):  
Kristen Gettys ◽  
Zhishi Ye ◽  
Mingji Dai
Keyword(s):  
Transition Metal ◽  
Small Molecule ◽  
Ring System ◽  
Reductive Cyclization ◽  
The Third ◽  
Methods Development ◽  
Recent Advances ◽  
Borrowing Hydrogen ◽  
Palladium Catalyzed ◽  
Metal Catalyzed

Piperazine ranks as the third most common N-heterocycle appearing in small-molecule pharmaceuticals. This review highlights recent advances in methods development for the construction of the piperazine­ ring system with particular emphasis on preparing carbon-substituted piperazines.1 Introduction2 Reduction of (Di)ketopiperazine3 N-Alkylation4 Transition-Metal-Catalyzed/Mediated Piperazine Synthesis4.1 The SnAP and SLAP Methods4.2 Palladium-Catalyzed Cyclization4.3 Gold-Catalyzed Cyclization4.4 Other Metal-Catalyzed/Mediated Cyclization4.5 Borrowing Hydrogen Strategy4.6 Imine Reductive Cyclization5 Reduction of Pyrazines6 Miscellaneous7 Conclusion

Palladium-Catalyzed Copper-Free Sonogashira Coupling of 2-Bromoarylcarbonyls: Synthesis of Isobenzofurans via One-Pot Reductive Cyclization

Synthesis ◽  
2017 ◽  
Vol 49 (23) ◽  
pp. 5149-5158
Author(s):  
Alavala Krishna Reddy ◽  
Gedu Satyanarayana
Keyword(s):  
Reductive Cyclization ◽  
Sonogashira Coupling ◽  
One Pot ◽  
One Pot Synthesis ◽  
Palladium Catalyzed ◽  
The One

Palladium-catalyzed copper-free Sonogashira coupling of 2-bromocarbonyls is presented. This method afforded the 2-alkynylaryl carbonyls, useful synthons for the accomplishment of many carbocyclic and heterocyclic motifs. Significantly, the strategy was extended to the one-pot synthesis of isobenzofurans via reduction followed by intramolecular 5-exo-dig cyclization.

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