scholarly journals Coenzyme q10 in patients with end-stage heart failure awaiting cardiac transplantation: A randomized, placebo-controlled study

2004 ◽  
Vol 27 (10) ◽  
pp. A26-A30 ◽  
Author(s):  
Stephen T. Sinatra ◽  
Marius Berman
Keyword(s):  
Heart Failure ◽  
Coenzyme Q10 ◽  
Cardiac Transplantation ◽  
Controlled Study ◽  
End Stage Heart Failure ◽  
End Stage

scholarly journals Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: A randomized, placebo-controlled study

2004 ◽  
Vol 27 (5) ◽  
pp. 295-299 ◽  
Author(s):  
Marius Berman ◽  
Arie Erman ◽  
Tuvia Ben-Gal ◽  
Dan Dvir ◽  
Georgios P. Georghiou ◽  
...  
Keyword(s):  
Heart Failure ◽  
Coenzyme Q10 ◽  
Cardiac Transplantation ◽  
Controlled Study ◽  
End Stage Heart Failure ◽  
End Stage

scholarly journals Double blind, placebo-controlled study of long-term intermittent dobutamine infusion with concomitant oral amiodarone for end stage heart failure

2003 ◽  
Vol 41 (6) ◽  
pp. 162-163
Author(s):  
Eleftheria Tsagalou ◽  
Maria Anastasiou-Nana ◽  
George Alexopoulos ◽  
John Terrovitis ◽  
Konstantinos Chalkias ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dobutamine Infusion ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
End Stage Heart Failure ◽  
End Stage

Device Therapy and Cardiac Transplantation for End-Stage Heart Failure

2010 ◽  
Vol 35 (1) ◽  
pp. 8-64 ◽  
Author(s):  
Barry A. Boilson ◽  
Eugenia Raichlin ◽  
Soon J. Park ◽  
Sudhir S. Kushwaha
Keyword(s):  
Heart Failure ◽  
Cardiac Transplantation ◽  
Device Therapy ◽  
End Stage Heart Failure ◽  
End Stage

Is there a treatment of end stage heart failure due to Ebstein's anomaly besides cardiac transplantation?

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
K Valeske ◽  
M Müller ◽  
J Bauer ◽  
N Hijjeh ◽  
D Schranz ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Transplantation ◽  
Ebstein’S Anomaly ◽  
Ebstein's Anomaly ◽  
End Stage Heart Failure ◽  
End Stage

Myocardial Gene Expression of Regulators of Myocyte Apoptosis and Myocyte Calcium Homeostasis During Hemodynamic Unloading by Ventricular Assist Devices in Patients With End-Stage Heart Failure

Circulation ◽  
1999 ◽  
Vol 100 (suppl_2) ◽  
Author(s):  
Babett Bartling ◽  
Hendrik Milting ◽  
Heike Schumann ◽  
Dorothea Darmer ◽  
Lativ Arusoglu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Sarcoplasmic Reticulum ◽  
Calcium Homeostasis ◽  
Cardiac Transplantation ◽  
Left Ventricular ◽  
Ventricular Assist ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Myocardial Gene Expression

Background —In patients with end-stage heart failure, characterized by an increased susceptibility to cardiomyocyte apoptosis and a labile cardiomyocyte calcium homeostasis, a ventricular assist device (VAD) is implanted for bridging to cardiac transplantation and results in myocardial unloading. Although phenotype changes in the failing heart are assumed to result from hemodynamic overload, the reversibility of these changes under unloading is unknown. Methods and Results —By use of quantitative reverse-transcription polymerase chain reaction, mRNA expression analyses were performed on left ventricular specimens obtained from 10 nonfailing donor hearts (from 8 patients with dilated cardiomyopathy and 2 patients with coronary heart disease) at the time of VAD implantation and 36 to 169 days later during VAD removal with subsequent cardiac transplantation. In terminally failing hearts before VAD support, left ventricular mRNA analyses revealed increased Pro-ANP, reduced antiapoptotic Bcl-x L and antiapoptotic Fas isoform FasExo6Del, and a decreased ratio of sarcoplasmic reticulum Ca 2+ -ATPase per sarcolemmal Na + -Ca 2+ exchanger in comparison with nonfailing ventricles. After VAD unloading, ventricular transcription of Pro-ANP was immediately normalized, and apoptotic DNA fragmentation was attenuated. In patients with dilated cardiomyopathy, mRNAs of Bcl-x L and FasExo6Del/Fas were enhanced depending on time on VAD. The Bcl-x L mRNA level correlated positively with that of the Bcl-x L protein. Transcription of sarcoplasmic reticulum Ca 2+ -ATPase/Na + -Ca 2+ exchanger demonstrated recovery in only 4 of 10 patients. Conclusions —Mechanical support of the failing heart induces a time-dependent change in myocardial gene expression compatible with a decreased susceptibility to apoptosis.

scholarly journals Differences in temporal risk of sudden and nonsudden death in patients with end-stage heart failure listed for cardiac transplantation

1996 ◽  
Vol 27 (2) ◽  
pp. 229
Author(s):  
Michael O. Sweeney ◽  
John B. Newell ◽  
Hasan Garan ◽  
Brian McGovern ◽  
Marc J. Semigran ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Transplantation ◽  
End Stage Heart Failure ◽  
End Stage
Sign in / Sign up

Export Citation Format

Share Document