Synthesis, Structure-Activity Relationship and Docking Studies of Substituted Aryl Thiazolyl Phenylsulfonamides as Potential Protein Tyrosine Phosphatase 1B Inhibitors

ChemMedChem ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. 1185-1190 ◽  
Author(s):  
Kanika Varshney ◽  
Swati Gupta ◽  
Neha Rahuja ◽  
Arun K. Rawat ◽  
Nagendra Singh ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Structure Activity Relationship ◽  
Docking Studies ◽  
Activity Relationship ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Structure Activity

Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

2003 ◽  
Vol 46 (11) ◽  
pp. 2093-2103 ◽  
Author(s):  
Gang Liu ◽  
Bruce G. Szczepankiewicz ◽  
Zhonghua Pei ◽  
David A. Janowick ◽  
Zhili Xin ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Quantative STRUCTURE Activity Relationship (QSAR) Study of a Series of Molecules Derived from 2,3-dihydro-1H- perimidine having Activity against Protein Tyrosine Phosphatase 1B

2021 ◽  
pp. 23-34
Author(s):  
Tuo Nanou Tiéba ◽  
Dembele Georges Stephane ◽  
Soro Doh ◽  
Konate Bibata ◽  
Kodjo Charles Guillaume ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
External Validation ◽  
Structure Activity Relationship ◽  
Quantitative Model ◽  
Activity Relationship ◽  
Protein Tyrosine Phosphatase 1B ◽  
Qsar Study ◽  
Protein Tyrosine ◽  
Structure Activity

In order to study the Quantitative Structure Activity Relationship (QSAR) against protein tyrosine phosphatase 1B and descriptors, we used a series of fourteen (14) molecules derived from perimidine. The compounds were optimized at the computational level B3LYP / 6-31 G (d, p), to obtain the descriptors of the model. This study was performed using the Linear Multiple Regression (MLR) method. This tool allowed us to obtain a quantitative model from the descriptors that are, the overall softness (S), the energy of the lowest vacant (ELUMO), the bond length l (N-C1). This model has good statistical performance (R2 = 0.958; RMCE = 0.110; F = 43.870). In addition, the external validation test of Tropsha and the domain of applicability from the levers were verified.

Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study

2018 ◽  
Vol 111 ◽  
pp. 474-481 ◽  
Author(s):  
Carina Proença ◽  
Marisa Freitas ◽  
Daniela Ribeiro ◽  
Joana L.C. Sousa ◽  
Félix Carvalho ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Structure Activity ◽  
Relationship Study

α-Bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure–Activity relationship

2002 ◽  
Vol 12 (21) ◽  
pp. 3047-3050 ◽  
Author(s):  
Gulnur Arabaci ◽  
Tian Yi ◽  
Hua Fu ◽  
Mary E. Porter ◽  
Kirk D. Beebe ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Phosphatase Inhibitors ◽  
Protein Tyrosine ◽  
Structure Activity

Structure–Activity Relationship and Rational Design of 3,4-Dephostatin Derivatives as Protein Tyrosine Phosphatase Inhibitors

Tetrahedron ◽  
2000 ◽  
Vol 56 (5) ◽  
pp. 741-752 ◽  
Author(s):  
Takumi Watanabe ◽  
Takayuki Suzuki ◽  
Yoji Umezawa ◽  
Tomio Takeuchi ◽  
Masami Otsuka ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Rational Design ◽  
Tyrosine Phosphatase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Phosphatase Inhibitors ◽  
Protein Tyrosine ◽  
Structure Activity

Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors

2010 ◽  
Vol 20 (19) ◽  
pp. 5732-5734 ◽  
Author(s):  
Swati Gupta ◽  
Gyanendra Pandey ◽  
Neha Rahuja ◽  
Arvind K. Srivastava ◽  
Anil K. Saxena
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Docking Studies ◽  
Protein Tyrosine Phosphatase 1B ◽  
Design Synthesis ◽  
Protein Tyrosine
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