Two parts of the nucleus prepositus hypoglossi project to two different subdivisions of the dorsolateral periaqueductal gray in cat

2005 ◽  
Vol 492 (3) ◽  
pp. 303-322 ◽  
Author(s):  
Esther Marije Klop ◽  
Leonora J. Mouton ◽  
Thomas Ehling ◽  
Gert Holstege
Keyword(s):  
Periaqueductal Gray ◽  
Nucleus Prepositus Hypoglossi ◽  
Prepositus Hypoglossi

scholarly journals Vestibular Imbalance Associated With a Lesion in the Nucleus Prepositus Hypoglossi Area

2004 ◽  
Vol 61 (9) ◽  
pp. 1440 ◽  
Author(s):  
Sang Won Seo ◽  
Ha Young Shin ◽  
Seo Hyun Kim ◽  
Sang Won Han ◽  
Kyung Yul Lee ◽  
...  
Keyword(s):  
Nucleus Prepositus Hypoglossi ◽  
Prepositus Hypoglossi

scholarly journals Nucleus prepositus hypoglossi lesions produce a unique ocular motor syndrome

Neurology ◽  
2016 ◽  
Vol 87 (19) ◽  
pp. 2026-2033 ◽  
Author(s):  
Sung-Hee Kim ◽  
David S. Zee ◽  
Sascha du Lac ◽  
Hyo Jung Kim ◽  
Ji-Soo Kim
Keyword(s):  
Ocular Motor ◽  
Nucleus Prepositus Hypoglossi ◽  
Prepositus Hypoglossi

Neurochemically defined cell columns in the nucleus prepositus hypoglossi of the cat and monkey

2006 ◽  
Vol 1094 (1) ◽  
pp. 127-137 ◽  
Author(s):  
Joan S. Baizer ◽  
James F. Baker
Keyword(s):  
Nucleus Prepositus Hypoglossi ◽  
Prepositus Hypoglossi

Eye Movement Deficits After Ibotenic Acid Lesions of the Nucleus Prepositus Hypoglossi in Monkeys. I. Saccades and Fixation

1997 ◽  
Vol 78 (4) ◽  
pp. 1753-1768 ◽  
Author(s):  
Chris R. S. Kaneko
Keyword(s):  
Eye Movement ◽  
Rhesus Macaques ◽  
Ibotenic Acid ◽  
Feedback Signal ◽  
Neural Integrator ◽  
Nucleus Prepositus Hypoglossi ◽  
System A ◽  
Classical Models ◽  
Prepositus Hypoglossi ◽  
Made In

Kaneko, Chris R. S. Eye movement deficits after ibotenic acid lesions of the nucleus prepositus hypoglossi in monkeys. I. Saccades and fixation. J. Neurophysiol. 78: 1753–1768, 1997. It has been suggested that the function of the nucleus prepositus hypoglossi (nph) is the mathematical integration of velocity-coded signals to produce position-coded commands that drive abducens motoneurons and generate horizontal eye movements. In early models of the saccadic system, a single integrator provided not only the signal that maintained steady gaze after a saccade but also an efference copy of eye position, which provided a feedback signal to control the dynamics of the saccade. In this study, permanent, serial ibotenic acid lesions were made in the nph of three rhesus macaques, and their effects were studied while the alert monkeys performed a visual tracking task. Localized damage to the nph was confirmed in both Nissl and immunohistochemically stained material. The lesions clearly were correlated with long-lasting deficits in eye movement. The animals' ability to fixate in the dark was compromised quickly and uniformly so that saccades to peripheral locations were followed by postsaccadic centripetal drift. The time constant of the drift decreased to approximately one-tenth of its normal values but remained 10 times longer than that attributable to the mechanics of the eye. In contrast, saccades were affected minimally. The results are more consistent with models of the neural saccade generator that use separate feedback and position integrators than with the classical models, which use a single multipurpose element. Likewise, the data contradict models that rely on feedback from the nph. In addition, they show that the oculomotor neural integrator is not a single neural entity but is most likely distributed among a number of nuclei.

Otolith-brain stem connectivity: evidence for differential neural activation by vestibular hair cells based on quantification of FOS expression in unilateral labyrinthectomized rats

1993 ◽  
Vol 70 (1) ◽  
pp. 117-127 ◽  
Author(s):  
G. D. Kaufman ◽  
J. H. Anderson ◽  
A. J. Beitz
Keyword(s):  
Brain Stem ◽  
Neuronal Activity ◽  
Inferior Olive ◽  
Periaqueductal Gray ◽  
Otolith Organs ◽  
Centripetal Acceleration ◽  
Axis Of Rotation ◽  
Prepositus Hypoglossi ◽  
Fos Expression ◽  
Inferior Olivary

1. The effects of acute and chronic labyrinthectomies on Fos-defined neuronal activity induced by rotation were determined with the use of quantitative image analysis procedures. Unilateral sodium arsanilate labyrinthectomies (UL) were performed either 24 h (acute) or 2 wk (chronic) before exposure to a 90 min, 2-G centripetal acceleration along the interaural axis that stimulated the intact otolith organs. The results obtained from both acute and chronic UL animals subjected to centripetal acceleration were compared with data obtained from nonrotated UL animals and fully intact, normal animals exposed to centripetal acceleration. Such comparisons allowed the definition of functional projections from the otolith organs of one labyrinth to vestibular related and inferior olivary brain stem nuclei in the rat. 2. The effect of the labyrinthectomy on nonrotated animals was first assessed. After acute UL, asymmetric Fos expression was present in the medial and inferior vestibular nuclei, the prepositus hypoglossi (bilaterally), the ipsilateral (with respect to the side of UL) dorsolateral periaqueductal gray, and the contralateral inferior olivary beta subnucleus, as previously described (Kaufman et al., 1992b). Except for minimal labeling in the contralateral prepositus hypoglossi and the dorsolateral periaqueductal gray, the Fos labeling that was present in the brain stem of acute UL animals was absent in chronic UL animals. Thus Fos neuronal activity appears to define a pattern of brain stem activation associated with the initial events that underlie vestibular compensation. 3. In acute UL rats, which were rotated, the contralateral beta subnucleus of the inferior olive had greater labeling (compared with nonrotated UL animals) when the lesion was away from the axis of rotation. In contrast, the ipsilateral beta subnucleus labeled when the lesion was towards the axis of rotation. Fos expression was observed bilaterally in the prepositus hypoglossi when the lesioned side was oriented toward the axis of rotation but was observed only in the contralateral prepositus nucleus when the lesioned side was oriented away from the axis of rotation. Finally, the dorsomedial cell column of the inferior olive (DMCC) was heavily labeled when the lesioned side was oriented towards the axis of rotation but was unlabeled when the lesioned side was oriented away from the axis of rotation. In acute UL nonrotated animals the DMCC was only lightly labeled. All other brain stem nuclear labeling was similar between the acute UL rotated and nonrotated animals.(ABSTRACT TRUNCATED AT 400 WORDS)

Potent inhibitory input to locus coeruleus from the nucleus prepositus hypoglossi

1989 ◽  
Vol 22 (5) ◽  
pp. 793-803 ◽  
Author(s):  
Matthew Ennis ◽  
Gary Aston-Jones
Keyword(s):  
Locus Coeruleus ◽  
Inhibitory Input ◽  
Nucleus Prepositus Hypoglossi ◽  
Prepositus Hypoglossi
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