Intramuscular nerve endings of sensory type in the small intestine, with a consideration of their probable function

The mode of action of cholecystokinin (CCK), an octapeptide fragment of CCK, caerulein, and pentagastrin on isolated guinea pig ileal muscle was investigated and their relative potencies determined. On a molar basis, octapeptide-CCK and caerulein were about twice as potent as CCK, whereas pentagastrin and Urecholine were respectively 23 and 46 times less potent. Scopolamine (6.84 × 10−4 M) inhibited the response to all four peptides relatively less than the response to Urecholine. Tetrodotoxin (0.1 μg/ml) inhibited the response to all peptides by 91%. It was concluded that the effect of these peptides on ileal muscle was largely mediated by cholinergic mechanisms. It could not be ascertained, however, whether the effect resulted solely from release of acetylcholine by nerve endings or from the participation of acetylcholine mainly as a synergist of the peptides' action on smooth muscle fibers.

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A case of myasthenia gravis with changes in the intramuscular nerve-endings

The Journal of Pathology and Bacteriology ◽

10.1002/path.1700710123 ◽

1956 ◽

Vol 71 (1) ◽

pp. 173-178 ◽

Cited By ~ 11

Author(s):

A. L. Woolf ◽

H. J. Bagnall ◽

P. Bauwens ◽

Edwin R. Bickerstaff

Keyword(s):

Myasthenia Gravis ◽

Nerve Endings ◽

Intramuscular Nerve

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DEGENERATION AND REGENERATION OF INTRAMUSCULAR NERVE ENDINGS (Study of nerve endings in over 100 biopsies)

Neuropathology ◽

10.1016/b978-1-4831-6677-3.50081-7 ◽

1959 ◽

pp. 314-316

Author(s):

A.L. WOOLF

Keyword(s):

Nerve Endings ◽

Intramuscular Nerve

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TETRAETHYLAMMONIUM-INDUCED CONTRACTIONS OF FROG'S SKELETAL MUSCLE: I. GENERAL CONSIDERATIONS

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y67-097 ◽

1967 ◽

Vol 45 (5) ◽

pp. 821-831 ◽

Cited By ~ 6

Author(s):

G. Beaulieu ◽

G. B. Frank

Keyword(s):

Latent Period ◽

Neuromuscular Transmission ◽

Nerve Endings ◽

Induced Response ◽

Sartorius Muscle ◽

Muscle Twitching ◽

Release Of Acetylcholine ◽

Intramuscular Nerve ◽

Unmyelinated Nerve ◽

Indirect Stimulation

The mechanism for the production of the 'twitching' response induced by tetraethylammonium (TEA) of the frog's sartorius muscle was investigated. A linear relation was found between the log TEA concentration and the log of the latent period for the onset of the muscle response. The minimum latent period was 5 to 10 sec. Previously it was suggested that TEA caused the release of acetylcholine from intramuscular nerve endings to produce this response (13). The findings that blocking neuromuscular transmission by d-tubocurarine, by reduced extracellular calcium concentrations, or by repetitive indirect stimulation in the presence of hemicholinium also prevented the TEA-induced muscle 'twitching' response support the above suggestion. Exposing the preparation to procaine concentrations too low to block neuromuscular transmission blocked the TEA-induced response, indicating that this response was due to an effect of TEA on the unmyelinated nerve endings.

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