Adrenalectomy-induced granule cell degeneration in the rat hippocampal dentate gyrus: Characterization of an in vivo model of controlled neuronal death

1993 ◽  
Vol 330 (3) ◽  
pp. 324-336 ◽  
Author(s):  
Robert S. Sloviter ◽  
Anne L. Sollas ◽  
Evelyn Dean ◽  
Simon Neubort
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Neuronal Death ◽  
In Vivo Model ◽  
Hippocampal Dentate Gyrus ◽  
Cell Degeneration

Characterization of cells newly generated after granule cell loss in the hippocampal dentate gyrus of mice

2010 ◽  
Vol 68 ◽  
pp. e368
Author(s):  
Tetsuya Tanaka ◽  
Tatsuo Shiba ◽  
Masanori Yoneyama ◽  
Kiyokazu Ogita
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Cell Loss ◽  
Hippocampal Dentate Gyrus

scholarly journals Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Julia Muellerleile ◽  
Aline Blistein ◽  
Astrid Rohlmann ◽  
Frederieke Scheiwe ◽  
Markus Missler ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Field Potential ◽  
Synaptic Function ◽  
Spatial Learning And Memory ◽  
Neurotransmitter Receptor ◽  
Cell Excitability ◽  
Neuronal Protein ◽  
Electrophysiological Recordings

Abstract Deletion of the autism candidate molecule neurobeachin (Nbea), a large PH-BEACH-domain containing neuronal protein, has been shown to affect synaptic function by interfering with neurotransmitter receptor targeting and dendritic spine formation. Previous analysis of mice lacking one allele of the Nbea gene identified impaired spatial learning and memory in addition to altered autism-related behaviours. However, no functional data from living heterozygous Nbea mice (Nbea+/−) are available to corroborate the behavioural phenotype. Here, we explored the consequences of Nbea haploinsufficiency on excitation/inhibition balance and synaptic plasticity in the intact hippocampal dentate gyrus of Nbea+/− animals in vivo by electrophysiological recordings. Based on field potential recordings, we show that Nbea+/− mice display enhanced LTP of the granule cell population spike, but no differences in basal synaptic transmission, synapse numbers, short-term plasticity, or network inhibition. These data indicate that Nbea haploinsufficiency causes remarkably specific alterations to granule cell excitability in vivo, which may contribute to the behavioural abnormalities in Nbea+/− mice and to related symptoms in patients.

scholarly journals Interleukin-1β increases neuronal death in the hippocampal dentate gyrus associated with status epilepticus in the developing rat

2017 ◽  
Vol 32 (9) ◽  
pp. 587-594
Author(s):  
C. Rincón-López ◽  
A. Tlapa-Pale ◽  
J.-S. Medel-Matus ◽  
J. Martínez-Quiroz ◽  
J.F. Rodríguez-Landa ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Dentate Gyrus ◽  
Neuronal Death ◽  
Interleukin 1Β ◽  
Hippocampal Dentate Gyrus ◽  
Developing Rat

scholarly journals Resistance to DNA Damaging Agents Produced Invasive Phenotype of Rat Glioma Cells—Characterization of a New in Vivo Model

Molecules ◽  
2016 ◽  
Vol 21 (7) ◽  
pp. 843 ◽  
Author(s):  
Sonja Stojković ◽  
Ana Podolski-Renić ◽  
Jelena Dinić ◽  
Željko Pavković ◽  
Jose Ayuso ◽  
...  
Keyword(s):  
Glioma Cells ◽  
In Vivo Model ◽  
Invasive Phenotype ◽  
Rat Glioma ◽  
Dna Damaging Agents

scholarly journals Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73928 ◽  
Author(s):  
Riitta Lindström ◽  
Päivi Lindholm ◽  
Jukka Kallijärvi ◽  
Li-ying Yu ◽  
T. Petteri Piepponen ◽  
...  
Keyword(s):  
In Vivo Model

P0975 : Characterization of an in vivo model of juvenile non-alcoholic fatty liver disease

2015 ◽  
Vol 62 ◽  
pp. S711-S712
Author(s):  
V. Marin ◽  
N. Rosso ◽  
M. Dal Ben ◽  
A. Raseni ◽  
C. Degrassi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
In Vivo Model ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals ENHANCED FLUORESCENCE IMAGING WITH DMSO-MEDIATED OPTICAL CLEARING

2010 ◽  
Vol 03 (03) ◽  
pp. 153-158 ◽  
Author(s):  
SANJEEV KARMA ◽  
JAMES HOMAN ◽  
CHARLES STOIANOVICI ◽  
BERNARD CHOI
Keyword(s):  
Fluorescence Emission ◽  
Model Systems ◽  
In Vivo Studies ◽  
In Vivo Model ◽  
Fluorescence Signal ◽  
Optical Clearing ◽  
Treated Site

Recent studies have demonstrated that topical application of glycerol on intact skin does not affect its optical scattering properties. Investigators from our research group recently revisited the use of dimethyl sulfoxide (DMSO) as an agent with optical clearing potential. We address the use of optical clearing to enhance quantitation of subsurface fluorescence emission. We employed both in vitro and in vivo model systems to study the effect of topical DMSO application on fluorescence emission. Our in vitro experiments performed on a tissue-simulating phantom suggest that DMSO-mediated optical clearing enables enhanced characterization of subsurface fluorophores. With topical DMSO application, a marked increase in fluorescence emission was observed. After 30 min, the fluorescence signal at the DMSO-treated site was 9× greater than the contralateral saline-treated site. This ratio increased to 13× at 105 min after agent application. In summary, DMSO is an effective optical clearing agent for improved fluorescence emission quantitation and warrants further study in preclinical in vivo studies. Based on outcomes from previous clinical studies on the toxicity profile of DMSO, we postulate that clinical application of DMSO as an optical clearing agent, can be performed safely, although further study is warranted.

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