Cellular retinol-binding protein type I is prominently and differentially expressed in the sensory epithelium of the rat cochlea and vestibular organs

1994 ◽  
Vol 349 (4) ◽  
pp. 596-602 ◽  
Author(s):  
Jukka Ylikoski ◽  
Ulla Pirvola ◽  
Ulf Eriksson
Keyword(s):  
Binding Protein ◽  
Sensory Epithelium ◽  
Differentially Expressed ◽  
Retinol Binding Protein ◽  
Type I ◽  
Rat Cochlea ◽  
Vestibular Organs ◽  
Cellular Retinol Binding Protein

scholarly journals Vitamin A–Sensitive Tissues in Transgenic Mice Expressing High Levels of Human Cellular Retinol-Binding Protein Type I Are Not Altered Phenotypically

1999 ◽  
Vol 129 (9) ◽  
pp. 1621-1627 ◽  
Author(s):  
Gunhild Trøen ◽  
Winnie Eskild ◽  
Sigurd H. Fromm ◽  
Luigi M. De Luca ◽  
David E. Ong ◽  
...  
Keyword(s):  
Vitamin A ◽  
Transgenic Mice ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Type I ◽  
Cellular Retinol Binding Protein

scholarly journals Cellular Retinol-Binding Protein Type I (CRBP-I) Regulates Adipogenesis

2010 ◽  
Vol 30 (14) ◽  
pp. 3412-3420 ◽  
Author(s):  
C. F. Zizola ◽  
S. K. Frey ◽  
S. Jitngarmkusol ◽  
B. Kadereit ◽  
N. Yan ◽  
...  
Keyword(s):  
Transcription Factors ◽  
High Fat Diet ◽  
Adipocyte Differentiation ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Type I ◽  
High Fat ◽  
Embryonic Fibroblasts ◽  
Glucose Tolerant ◽  
Cellular Retinol Binding Protein

ABSTRACT Adipogenesis is governed by a well-documented cascade of transcription factors. However, less is known about non-transcription factors that govern early stages of adipogenesis. Here we show that cellular retinol-binding protein type I (CRBP-I), a small cytosolic binding protein for retinol and retinaldehyde, is specifically restricted to preadipocytes in white adipose tissue. The absence of CRBP-I in mice (CRBP-I-KO mice) leads to increased adiposity. Despite increased adiposity, CRBP-I-KO mice remain more glucose tolerant and insulin sensitive during high-fat-diet feeding. 3T3-L1 cells deficient in CRBP-I or mouse embryonic fibroblasts derived from CRBP-I-KO mice had increased adipocyte differentiation and triglyceride (TG) accumulation. This was due to increased expression and activity of PPARγ, while other transcription factor pathways in early and late differentiation remained unchanged. Conversely, the overexpression of CRBP-I in 3T3-L1 cells results in decreased TG accumulation. In conclusion, CRBP-I is a cytosolic protein specifically expressed in preadipocytes that regulates adipocyte differentiation in part by affecting PPARγ activity.

Solvent-induced ligand dissociation and conformational states of Cellular Retinol-Binding Protein Type I

2004 ◽  
Vol 1703 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Federico Torta ◽  
Alexandra E. Dyuysekina ◽  
Davide Cavazzini ◽  
Andrea Fantuzzi ◽  
Valentina E. Bychkova ◽  
...  
Keyword(s):  
Binding Protein ◽  
Retinol Binding Protein ◽  
Type I ◽  
Conformational States ◽  
Ligand Dissociation ◽  
Cellular Retinol Binding Protein
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