Exploring the Drug-Binding Site Sudlow I of Human Serum Albumin: The Role of Water and Trp214 in Molecular Recognition and Ligand Binding

ChemPhysChem ◽  
2010 ◽  
Vol 12 (2) ◽  
pp. 270-274 ◽  
Author(s):  
Osama K. Abou-Zied ◽  
Najla Al-Lawatia
Keyword(s):  
Human Serum Albumin ◽  
Molecular Recognition ◽  
Ligand Binding ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Site ◽  
Drug Binding ◽  
Drug Binding Site

scholarly journals Probing the Sudlow binding site with warfarin: how does gold nanocluster growth alter human serum albumin?

2016 ◽  
Vol 18 (33) ◽  
pp. 22874-22878 ◽  
Author(s):  
B. A. Russell ◽  
P. A. Mulheran ◽  
D. J. S. Birch ◽  
Y. Chen
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Site ◽  
Gold Nanoclusters ◽  
Drug Binding ◽  
Gold Nanocluster ◽  
Drug Binding Site ◽  
Major Drug

Gold Nanoclusters (AuNCs) synthesised using Human Serum Albumin (HSA) as a stable scaffold are shown to modify the major drug binding site, Sudlow site I. Upon AuNC nucleation within HSA, warfarin was observed to no longer bind to Sudlow I, remaining free in solution.

The disaccharide anthracycline MEN 10755 binds human serum albumin to a non-classical drug binding site

2002 ◽  
Vol 10 (11) ◽  
pp. 3425-3430 ◽  
Author(s):  
Luigi Messori ◽  
Francesca Piccioli ◽  
Silvia Gabrielli ◽  
Pierluigi Orioli ◽  
Leonardo Angeloni ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Site ◽  
Drug Binding ◽  
Drug Binding Site

scholarly journals The classification of drugs on the basis of the drug-binding site on human serum albumin.

1982 ◽  
Vol 30 (12) ◽  
pp. 4489-4493 ◽  
Author(s):  
MOTOHARU IWATSURU ◽  
HIDEO NISHIGORI ◽  
KAZUO MARUYAMA
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Site ◽  
Drug Binding ◽  
Drug Binding Site

Study of Modification of Drug Binding Site I of Human Serum Albumin by Sodium Hypochlorite by Time Resolved Fluorescent Spectroscopy

2021 ◽  
Vol 15 (3) ◽  
pp. 254-259
Author(s):  
T. I. Syrejshchikova ◽  
N. V. Smolina ◽  
M. G. Uzbekov ◽  
V. V. Brilliantova ◽  
E. D. Syromyatnikova ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Site ◽  
Sodium Hypochlorite ◽  
Drug Binding ◽  
Time Resolved ◽  
Fluorescent Spectroscopy ◽  
Drug Binding Site
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