Overview of Relaxation Dispersion NMR Spectroscopy to Study Protein Dynamics and Protein‐Ligand Interactions

2018 ◽  
Vol 92 (1) ◽  
Author(s):  
Erik Walinda ◽  
Daichi Morimoto ◽  
Kenji Sugase
Keyword(s):  
Nmr Spectroscopy ◽  
Protein Dynamics ◽  
Relaxation Dispersion ◽  
Protein Ligand Interactions ◽  
Ligand Interactions ◽  
Relaxation Dispersion Nmr

scholarly journals S03A3 Metastable structure detected by relaxation dispersion NMR spectroscopy(Visualising Dynamical Aspects of A Protein Molecule)

2007 ◽  
Vol 47 (supplement) ◽  
pp. S4
Author(s):  
Kenji Sugase ◽  
Jane H. Dyson ◽  
Peter E. Wright
Keyword(s):  
Nmr Spectroscopy ◽  
Protein Molecule ◽  
Relaxation Dispersion ◽  
Metastable Structure ◽  
Relaxation Dispersion Nmr

scholarly journals Correction: 19F multiple-quantum coherence NMR spectroscopy for probing protein–ligand interactions

RSC Advances ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 3503-3503
Author(s):  
Anna Zawadzka-Kazimierczuk ◽  
Mate Somlyay ◽  
Hanspeter Kaehlig ◽  
George Iakobson ◽  
Petr Beier ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Quantum Coherence ◽  
Multiple Quantum ◽  
Protein Ligand Interactions ◽  
Ligand Interactions ◽  
Multiple Quantum Coherence

Correction for ‘19F multiple-quantum coherence NMR spectroscopy for probing protein–ligand interactions’ by Anna Zawadzka-Kazimierczuk et al., RSC Adv., 2018, 8, 40687–40692.

scholarly journals Probing RNA dynamics via longitudinal exchange and CPMG relaxation dispersion NMR spectroscopy using a sensitive 13C-methyl label

2011 ◽  
Vol 39 (10) ◽  
pp. 4340-4351 ◽  
Author(s):  
Karin Kloiber ◽  
Romana Spitzer ◽  
Martin Tollinger ◽  
Robert Konrat ◽  
Christoph Kreutz
Keyword(s):  
Nmr Spectroscopy ◽  
Relaxation Dispersion ◽  
Rna Dynamics ◽  
Cpmg Relaxation Dispersion ◽  
Relaxation Dispersion Nmr

scholarly journals Binding Kinetics of Histone Chaperone Chz1 and Variant Histone H2A.Z-H2B by Relaxation Dispersion NMR Spectroscopy

2009 ◽  
Vol 387 (1) ◽  
pp. 1-9 ◽  
Author(s):  
D. Flemming Hansen ◽  
Zheng Zhou ◽  
Haniqiao Feng ◽  
Lisa M. Miller Jenkins ◽  
Yawen Bai ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Histone Chaperone ◽  
Relaxation Dispersion ◽  
Binding Kinetics ◽  
Relaxation Dispersion Nmr ◽  
Kinetics Of

scholarly journals The Energetics of a Three-State Protein Folding System Probed by High-Pressure Relaxation Dispersion NMR Spectroscopy

2015 ◽  
Vol 54 (38) ◽  
pp. 11157-11161 ◽  
Author(s):  
Vitali Tugarinov ◽  
David S. Libich ◽  
Virginia Meyer ◽  
Julien Roche ◽  
G. Marius Clore
Keyword(s):  
High Pressure ◽  
Protein Folding ◽  
Nmr Spectroscopy ◽  
Relaxation Dispersion ◽  
Pressure Relaxation ◽  
Relaxation Dispersion Nmr

scholarly journals Spatially Resolved STD-NMR Applied to the Study of Solute Transport in Biphasic Systems: Application to Protein-Ligand Interactions

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1984978 ◽  
Author(s):  
Ridvan Nepravishta ◽  
Serena Monaco ◽  
Juan C. Muñoz-García ◽  
Yaroslav Z. Khimyak ◽  
Jesus Angulo
Keyword(s):  
Nmr Spectroscopy ◽  
Solute Exchange ◽  
Spatially Resolved ◽  
Protein Ligand Interactions ◽  
Ligand Interactions ◽  
Std Nmr ◽  
Underlying Mechanisms ◽  
Solute Dynamics ◽  
Pharmacological Screening ◽  
Biphasic Systems

Fluid biphasic systems are one of the most interesting dynamic systems in chemistry and biochemistry. In nuclear magnetic resonance (NMR) spectroscopy, the study of the solute dynamics across fluid biphasic systems requires the introduction of dedicated NMR methods, due to their intrinsic heterogeneity. Diffusion and spatially resolved NMR techniques represent a useful approach for dealing with the study of solutes in biphasic systems and have been applied lately with success. Nevertheless, other potential applications of NMR spectroscopy for biphasic systems remain to be explored. In this proof-of-concept communication, we specifically aimed to investigate whether solute exchange between two immiscible phases can be followed by NMR experiments involving transfer of magnetization. To that aim, we have used spatially resolved saturation transfer difference NMR (SR-STD NMR) experiments to analyze solute exchange by transfer of saturation from one phase to the other in a biphasic system and have explored which are the underlying mechanisms leading to the transfer of magnetization between phases and the limits of the approach. We hereby demonstrate that SR-STD NMR is feasible and that it might be implemented in pharmacological screening for binders of biological receptors or in the study of chemical and biochemical reactions occurring at interfaces.

scholarly journals Excited States of Nucleic Acids Probed by Proton Relaxation Dispersion NMR Spectroscopy

2016 ◽  
Vol 128 (39) ◽  
pp. 12187-12191 ◽  
Author(s):  
Michael Andreas Juen ◽  
Christoph Hermann Wunderlich ◽  
Felix Nußbaumer ◽  
Martin Tollinger ◽  
Georg Kontaxis ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Nucleic Acids ◽  
Excited States ◽  
Relaxation Dispersion ◽  
Proton Relaxation ◽  
Relaxation Dispersion Nmr
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