Steady-state serum levels of quinidine and active metabolites in cardiac patients with varying degrees of renal function

1978 ◽  
Vol 24 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Dennis E. Drayer ◽  
David T. Lowenthal ◽  
Kathleen M. Restivo ◽  
Allan Schwartz ◽  
Clarence E. Cook ◽  
...  
Keyword(s):  
Renal Function ◽  
Steady State ◽  
Serum Levels ◽  
Cardiac Patients ◽  
Active Metabolites ◽  
Steady State Serum

Steady-State Serum Concentrations of Dothiepin and Northiaden after Two Dosage Regimens of Dothiepin Hydrochloride (Prothiaden)

1973 ◽  
Vol 1 (2) ◽  
pp. 391-397
Author(s):  
B R S Nakra ◽  
R C Glass ◽  
J A Rees
Keyword(s):  
Steady State ◽  
Parent Drug ◽  
State Level ◽  
Serum Levels ◽  
Single Daily Dose ◽  
Serum Concentrations ◽  
Dosage Regimens ◽  
Daily Dose ◽  
Steady State Serum ◽  
Steady State Levels

Five healthy volunteers took part in a crossover study which examined the serum concentrations of dothiepin and northiaden after a 25 mg three times a day and a 75 mg once a day dosage regimen of Prothiaden. The inter-individual variation of serum levels was large after either schedule which is to be expected with this group of drugs. The minimum steady-state level of dothiepin tended to be lower after the single daily dose, but the differences were small and not statistically significant. The approximate maximum steady-state levels of dothiepin showed large intra- and inter-subject variation and no obvious trend. The values of the desmethylated metabolite, northiaden, tended to follow the dothiepin concentrations but were lower than the parent drug. Average steady-state levels tended, with one exception, to be very similar after both regimens with no evidence of any trend when comparing the two regimens. The study showed that the two regimens yielded similar steady-state serum concentrations both of drug and metabolite but inter-individual differences were large.

Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man

2009 ◽  
Vol 61 (6) ◽  
pp. 357-367 ◽  
Author(s):  
Birger Stensgaard Hansen ◽  
Mogens Dam ◽  
Jens Brandt ◽  
Eigill F. Hvidberg ◽  
Helle Angelo ◽  
...  
Keyword(s):  
Steady State ◽  
Protein Binding ◽  
Serum Levels ◽  
Steady State Serum

Spironolactone Metabolism: Steady-State Serum Levels of the Sulfur-Containing Metabolites

1989 ◽  
Vol 29 (4) ◽  
pp. 342-347 ◽  
Author(s):  
Peter Gardiner ◽  
Kathy Schrode ◽  
David Quinlan ◽  
Bernard K. Martin ◽  
Donald R. Boreham ◽  
...  
Keyword(s):  
Steady State ◽  
Serum Levels ◽  
Steady State Serum ◽  
Sulfur Containing

scholarly journals Marked increase in steady-state serum levels achieved with itraconazole oral solution compared with capsule formulation

2007 ◽  
Vol 60 (4) ◽  
pp. 908-909 ◽  
Author(s):  
J. Freeman ◽  
A. Heshmati ◽  
D. Holland ◽  
R. Ticehurst ◽  
S. Lang
Keyword(s):  
Steady State ◽  
Serum Levels ◽  
Oral Solution ◽  
Capsule Formulation ◽  
Steady State Serum
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