scholarly journals Atypical adenoma of the thyroid diagnosed as anaplastic cancer by cytopathology

2017 ◽  
Vol 45 (10) ◽  
pp. 928-933
Author(s):  
Hiromitsu Hatakeyama ◽  
Kimiko Hoshino ◽  
Kenji Mizoguchi ◽  
Takayoshi Suzuki ◽  
Kanako C. Hatanaka ◽  
...  
Keyword(s):  
Atypical Adenoma

Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide

2013 ◽  
Vol 47 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Akira Matsuno ◽  
Mineko Murakami ◽  
Katsumi Hoya ◽  
Shoko M. Yamada ◽  
Shinya Miyamoto ◽  
...  
Keyword(s):  
Pituitary Carcinoma ◽  
Atypical Adenoma

scholarly journals Coexistence of atypical adenoma, adenoma with bizarre nuclei and follicular variant of papillary carcinoma of the thyroid

2013 ◽  
Vol 56 (4) ◽  
pp. 399
Author(s):  
Teresa Pusiol ◽  
Doriana Morichetti ◽  
MariaGrazia Zorzi
Keyword(s):  
Papillary Carcinoma ◽  
Follicular Variant ◽  
Atypical Adenoma

Two cases of atypical adenoma of the thyroid-Is atypical adenoma of the thyroid a true benign lesion?-

2010 ◽  
Vol 49 (3) ◽  
pp. 190-195 ◽  
Author(s):  
Mitsuhiro TACHIBANA ◽  
Yumi HASHIMOTO ◽  
Tamae SONE ◽  
Naoki OOISHI ◽  
Tatsuo UENO ◽  
...  
Keyword(s):  
Benign Lesion ◽  
Atypical Adenoma

Robotic-assisted transaxillary parathyroidectomy of an atypical adenoma

2011 ◽  
Vol 21 (3) ◽  
pp. 201-205 ◽  
Author(s):  
Leah Katz ◽  
Mohamed Abdel Khalek ◽  
Byron Crawford ◽  
Emad Kandil
Keyword(s):  
Robotic Assisted ◽  
Atypical Adenoma

Parathyroid Atypical Adenoma

2018 ◽  
pp. 376-381
Author(s):  
Vania Nosé
Keyword(s):  
Atypical Adenoma

scholarly journals Parathyroid Carcinoma: The Importance of High Clinical Suspicion for a Correct Management

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Gabriele Ricci ◽  
Marco Assenza ◽  
Marco Barreca ◽  
Gianluca Liotta ◽  
Livio Paganelli ◽  
...  
Keyword(s):  
Parathyroid Carcinoma ◽  
Central Compartment ◽  
Complete Resection ◽  
Clinical Suspicion ◽  
Initial Operation ◽  
En Bloc ◽  
Atypical Adenoma ◽  
Lung Lobectomy ◽  
High Clinical Suspicion ◽  
Secondary Referral Hospital

Background. Parathyroid carcinoma is an infrequent clinical entity whose diagnosis is very challenge. Indeed a pre-operative or intraoperative diagnosis of parathyroid carcinoma is reported in less than half cases described in the literature.Patients and Methods. A systematic review of pathological reports of our secondary referral hospital was done. From 2003 to 2011 one hundred and forty-four patients were operated for hyperparathyroidism. One patient with atypical adenoma and three patients with parathyroid carcinoma were included in this paper.Results. Anen blocresection of the tumor was performed in three patients. Two of this patients with diagnosis of parathyroid carcinoma are alive with no evidence of recurrence or metastasis, respectively, 48 and 60 months after the operation; one patient with diagnosis of atypical adenoma died for other disease 16 months after the operation. In the last patient a simple parathyroidectomy was performed. After that histology revealed the diagnosis of parathyroid carcinoma the patient underwent reoperation for left hemithyroidectomy and central compartment lymph node clearance. After 30 months a lung lobectomy was done due to metastasis.Conclusion. Parathyroid carcinoma should be considered in the differential diagnosis of PTH-dependent hypercalcemia because optional outcomes are associated with complete resection of the tumor at the time of initial operation.

The Past, Present, and Future Statuses of Formerly Classified “Atypical Pituitary Adenomas”: A Clinicopathological Assessment of 101 Cases in a Cohort of More than 1,000 Pure Endoscopically Treated Patients in Single Center

2020 ◽  
Author(s):  
Ercan Bal ◽  
İbrahim Kulaç ◽  
Selim Ayhan ◽  
Figen Söylemezoğlu ◽  
Mustafa Berker
Keyword(s):  
Pituitary Adenomas ◽  
Labeling Index ◽  
World Health ◽  
Pituitary Neoplasms ◽  
Ki 67 ◽  
Cavernous Sinus Invasion ◽  
Atypical Adenoma ◽  
Endocrine Organs ◽  
Significant Difference ◽  
Cure Rates

Abstract Aim This study was aimed to assess the clinical aggressiveness of pituitary neoplasms that were previously defined as atypical adenomas. Methods A total of 1,042 pituitary adenomas were included in the study and 101 of them were diagnosed as atypical adenoma. Demographic characteristics, radiological evaluations, and clinical information were obtained from a computer-based patient database. Cases were categorized as atypical or typical using the criteria listed in 2004 Classification of Tumors of Endocrine Organs. Results The cure and reoperation rates did not show any statistically significant difference between the typical and atypical adenomas. However, a higher Ki-67 labeling index was found to be associated with a higher rate of reoperation (p = 0.008) in atypical adenomas. Of note, cavernous sinus invasion or parasellar extension was found to be associated with lower cure rates in patients with atypical pituitary adenomas (p < 0.001 and p = 0.001, respectively). Conclusion Although atypical pituitary adenomas are known to be more invasive, this study demonstrated that the reoperation and cure rates are the same for typical and atypical adenomas. Our findings advocate for omitting the use of atypical adenoma terminology based solely on pathological evaluation. As stated in the 4th edition of the World Health Organization (WHO) classification, accurate tumor subtyping, evaluation of proliferation by means of mitotic count and Ki-67 labeling index, and radiological and intraoperative assessments of tumor invasion should be taken into consideration in the management of such neoplasms.

scholarly journals Diagnosis of Parathyroid Tumors in Familial Isolated Hyperparathyroidism with HRPT2 Mutation: Implications for Cancer Surveillance

2006 ◽  
Vol 91 (8) ◽  
pp. 2827-2832 ◽  
Author(s):  
Vito Guarnieri ◽  
Alfredo Scillitani ◽  
Lucia Anna Muscarella ◽  
Claudia Battista ◽  
Nazzareno Bonfitto ◽  
...  
Keyword(s):  
Parathyroid Carcinoma ◽  
Stop Codon ◽  
Premature Stop Codon ◽  
Serum Biochemistry ◽  
Normal Serum ◽  
Cancer Surveillance ◽  
Atypical Adenoma ◽  
Normal Serum Calcium ◽  
Atypical Parathyroid Adenoma ◽  
Hrpt2 Gene

Abstract Context: Mutations of the HRPT2 gene have recently been implicated in the development of parathyroid carcinoma. Objective: The objective of this study was early diagnosis of parathyroid tumor in a family with germline HRPT2 mutation. Patients, Methods, and Results: In a 40-yr-old male previously treated for parathyroid atypical adenoma, we screened the 17 translated HRPT2 exons and their exon-intron boundaries and found a germline frameshift mutation in exon 7 (685delAGAG) predicting a premature stop codon at nucleotides 767–769. Nine family members (age, 33.9 ± 19.8 yr, mean ± sd) also carry the mutation, but eight have had normal serum calcium. Biochemical and ultrasonographic evaluation uncovered a 27-yr-old hypercalcemic carrier niece with an atypical parathyroid adenoma, and a 43-yr-old normocalcemic carrier sister was found by ultrasonography to have an extrathyroidal nodule, which proved to be parathyroid carcinoma. The index case, 12 yr after surgery, was normocalcemic, but ultrasonography revealed an extrathyroidal nodule in the contralateral hemithyroid tissue that proved to be atypical adenoma. Conclusions: Our report confirms that germline mutations of HRPT2 gene may be associated with multiple parathyroid neoplasms. Our experience suggests that longitudinal surveillance by serum biochemistry alone may not be 100% sensitive, and addition of routine neck ultrasonography is a readily accepted adjunct that may facilitate earlier disease detection in some families.

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