Pituitary Adenoma
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Meifen Shen ◽  
Guixiao Sheng ◽  
Yan Yang ◽  
Chao Wu ◽  
Chen Ma ◽  

IntroductionIt is necessary to investigate the current psychological distress and needs status of patients with pituitary adenoma in China.Material and methodsPatients with pituitary adenoma treated in our hospital from May 2019 to December 2019 were included. The psychological distress and needs scale for pituitary adenoma patients was used to investigate the psychological distress and needs of patients. Besides, univariate and multiple linear regression analyses were conducted to analyze the influencing factors.ResultsA total of 254 valid questionnaires were included. The total psychological distress and need score of patients with pituitary adenoma was (23.89±18.41) and (21.91±20.03) points respectively. There were significant differences on the psychological distress score in different occupational status, personal income, types of pituitary adenomas, size of pituitary adenoma, invasiveness, endocrine level and history of surgery (all p<0.05). The size of pituitary adenoma, endocrine level and pituitary adenoma type were the influencing factors of patients' psychological distress(all p<0.05). There were significant differences on the need score in different age, occupational status, personal income, types of pituitary adenomas and endocrine level(all p<0.05). Endocrine level, other rare types of pituitary adenoma and age were the influencing factors of patients' needs (all p<0.05).ConclusionsOur study is one of the few studies focused on the psychological distress and needs status of Chinese patients with pituitary adenoma. Medical staff should pay attention to the psychological distress of patients with large, rare type of pituitary adenomas and abnormal endocrine level, and take corresponding interventions to alleviate their psychological distress.

Neurosurgery ◽  
2021 ◽  
Vol 89 (Supplement_2) ◽  
pp. S64-S64
Young Soo Chung ◽  
Minkyun Na ◽  
Jihwan Yoo ◽  
Woohyun Kim ◽  
In-Ho Jung ◽  

2021 ◽  
Vol Publish Ahead of Print ◽  
Chen-Xi Liu ◽  
Sheng-Zhong Wang ◽  
Li-Jun Heng ◽  
Yu Han ◽  
Yu-Hui Ma ◽  

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi158-vi158
Syed Ather Enam ◽  
Fauzan Alam Hashmi ◽  
Sanam Mir Ghazi ◽  
Ahsan Ali Khan ◽  
Muhammad Bilal Tariq ◽  

Abstract BACKGROUND Giant pituitary adenomas (GPA) are uncommon and highly variable in morphology and extension. There is no scoring system that considers all the dimensions of adenoma invasion. We developed a new Giant Pituitary Adenoma score and report our surgical experience and evaluate outcomes after resection of these tumors in accordance with the preoperative score. METHODS We developed a novel scoring system for classifying giant pituitary adenomas, and 11-year data of GPA surgery at our center was collected retrospectively, based on this scoring system. GPA Score considered tumor’s parasellar extension, encasement of cavernous internal carotid artery (ICA), suprasellar extension &gt; 2 cm, suprasellar extension &gt; 4cm and retrosellar extension. Maximum possible score was 9. The scoring system was applied to 53 patients of GPA who underwent surgical resection between January 1, 2006, and December 2017. The Lundin-Pederson (ABC/2) method was used to calculate the tumor volume both pre- and post-resection and linear regression was used to assess the relationship between extent of tumor resection and GPA score. RESULTS The median age of the study population was 42.08 ± 16.49 years. The mean maximum diameter of the pituitary adenomas was 5.0 cm (range 4.0 cm-8.5cm) while the mean volume of the adenomas was 27.3 cm3 (range 10 cm3-149 cm3). There were 3 cases of score 2, 5 cases of score 3, 13 cases of score 4, 20 cases of score 5, 9 cases of score 6 and 3 cases of score 7. The range of tumor volumes of tumors for scores from 2-7 was 17.3 cm3 to 65.8 cm3 and GPA score was correlated with the percent residual tumor using linear regression that was statistically significant (p= 0.001). CONCLUSION GPA Score is a reliable scoring system to predict the extent and subsequent difficulty in tumor resection in GPA.

2021 ◽  
Vol 11 (1) ◽  
Da Hyun Lee ◽  
Ji Eun Park ◽  
Yeo Kyung Nam ◽  
Joonsung Lee ◽  
Seonok Kim ◽  

AbstractEven a tiny functioning pituitary adenoma could cause symptoms; hence, accurate diagnosis and treatment are crucial for management. However, it is difficult to diagnose a small pituitary adenoma using conventional MR sequence. Deep learning-based reconstruction (DLR) using magnetic resonance imaging (MRI) enables high-resolution thin-section imaging with noise reduction. In the present single-institution retrospective study of 201 patients, conducted between August 2019 and October 2020, we compared the performance of 1 mm DLR MRI with that of 3 mm routine MRI, using a combined imaging protocol to detect and delineate pituitary adenoma. Four readers assessed the adenomas in a pairwise fashion, and diagnostic performance and image preferences were compared between inexperienced and experienced readers. The signal-to-noise ratio (SNR) was quantitatively assessed. New detection of adenoma, achieved using 1 mm DLR MRI, was not visualised using 3 mm routine MRI (overall: 6.5% [13/201]). There was no significant difference depending on the experience of the readers in new detections. Readers preferred 1 mm DLR MRI over 3 mm routine MRI (overall superiority 56%) to delineate normal pituitary stalk and gland, with inexperienced readers more preferred 1 mm DLR MRI than experienced readers. The SNR of 1 mm DLR MRI was 1.25-fold higher than that of the 3 mm routine MRI. In conclusion, the 1 mm DLR MRI achieved higher sensitivity in the detection of pituitary adenoma and provided better delineation of normal pituitary gland than 3 mm routine MRI.

2021 ◽  
Vol 21 (1) ◽  
Congxin Dai ◽  
Bowen Sun ◽  
Shusen Guan ◽  
Wei Wang ◽  
Honggang Liu ◽  

Abstract Background Pituitary carcinomas (PCs), defined as distant metastases of pituitary neoplasms, are very rare malignancies. Because the clinical presentation of PCs is variable, early diagnosis and management remain challenging. PCs are always refractory to comprehensive treatments, and patients with PCs have extremely poor prognoses. Case presentation We describe one case of a prolactin-secreting pituitary adenoma (PA) refractory to conventional therapy that evolved into a PC with intraspinal metastasis. A 34-year-old female was diagnosed with an invasive prolactin-secreting PA in 2009 and was unresponsive to medical treatment with bromocriptine. The tumor was gross totally removed via transsphenoidal surgery (TSS). However, the patient experienced multiple tumor recurrences or regrowth despite comprehensive treatments, including medical therapy, two gamma knife radiosurgeries (GKSs), and four frontal craniotomies. In 2016, she was found to have an intradural extramedullary mass at the level of the fourth lumbar vertebra. The intraspinal lesion was completely resected and was confirmed as a metastatic PC based on histomorphology and immunohistochemical staining. The literature on the diagnosis, molecular pathogenesis, treatment, and prognosis of patients with prolactin-secreting PCs was reviewed. Conclusion PCs are very rare neoplasms with variable clinical features and poor prognosis. Most PCs usually arise from aggressive PAs refractory to conventional therapy. There is no reliable marker to identify aggressive PAs with a risk for progression to PCs; thus, it is difficult to diagnose these PCs early until the presence of metastatic lesions. It is still very challenging to manage patients with PCs due to a lack of standardized protocols for diagnosis and treatment. Establishing molecular biomarkers and the pathobiology of PCs could help in the early identification of aggressive PAs most likely to evolve into PCs.

2021 ◽  
Vol 4 (2) ◽  
pp. 76-80
Jae Hyun Park ◽  
Tae Hoon Roh ◽  
Jang-Hee Kim ◽  
Se-Hyuk Kim

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