Synthetic lethality of PARP and NAMPT inhibition in triple‐negative breast cancer cells

Ilirjana Bajrami; Asha Kigozi; Antoinette Van Weverwijk; Rachel Brough; Jessica Frankum; Christopher J. Lord; Alan Ashworth

doi:10.1002/emmm.201201250

Synthetic lethality of PARP and NAMPT inhibition in triple‐negative breast cancer cells

EMBO Molecular Medicine ◽

10.1002/emmm.201201250 ◽

2012 ◽

Vol 4 (10) ◽

pp. 1087-1096 ◽

Cited By ~ 63

Author(s):

Ilirjana Bajrami ◽

Asha Kigozi ◽

Antoinette Van Weverwijk ◽

Rachel Brough ◽

Jessica Frankum ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Synthetic Lethality

Download Full-text

Abstract 5471: Contextual synthetic lethality in human triple negative breast cancer cells involving a novel interaction between DNA repair proteins EGFR, PARP1, and BRCA1

10.1158/1538-7445.am2014-5471 ◽

2014 ◽

Author(s):

Jennifer Anne Stanley ◽

Somaira Nowsheen ◽

Tiffiny Cooper ◽

Andres Forero ◽

Alfred LoBuglio ◽

...

Keyword(s):

Breast Cancer ◽

Dna Repair ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Synthetic Lethality ◽

Dna Repair Proteins

Download Full-text

Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6

International Journal of Oncology ◽

10.3892/ijo.2015.2982 ◽

2015 ◽

Vol 47 (1) ◽

pp. 122-132 ◽

Cited By ~ 12

Author(s):

YONG WEON YI ◽

KYUSIC YOU ◽

EDWARD JEONG BAE ◽

SAHNG-JUNE KWAK ◽

YEON-SUN SEONG ◽

...

Keyword(s):

Breast Cancer ◽

Ribosomal Protein ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Synthetic Lethality ◽

Ribosomal Protein S6 ◽

Dual Inhibition

Download Full-text

Faculty Opinions recommendation of Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737060005.793568589 ◽

2019 ◽

Author(s):

Junjie Chen

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative

Download Full-text

MiRNAs-181a/b as Predictive biomarkers for olaparib sensitivity in triple-negative breast cancer cells.

Biochemistry Letters ◽

10.21608/blj.2017.47612 ◽

2017 ◽

Vol 12 (1) ◽

pp. 221-229

Author(s):

Abeer M. Ashmawy ◽

Mona A. Sheta ◽

Faten Zahran ◽

Abdel Hady A. Abdel Wahab

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Predictive Biomarkers

Download Full-text

microRNA-506-3p suppresses the proliferation of triple negative breast cancer cells via targeting SNAI2

Molecular & Cellular Toxicology ◽

10.1007/s13273-021-00160-7 ◽

2021 ◽

Vol 17 (4) ◽

pp. 513-522

Author(s):

Xuye Zhao ◽

Xiangdong Bai ◽

Weina Li ◽

Xuezhen Gao ◽

Xiaoli Wang ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative

Download Full-text

Fluorouracil uptake in triple‐negative breast cancer cells: Negligible contribution of equilibrative nucleoside transporters 1 and 2

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2261 ◽

2021 ◽

Author(s):

Saki Noguchi ◽

Akinori Takagi ◽

Takahiro Tanaka ◽

Yu Takahashi ◽

Xiaole Pan ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Nucleoside Transporters ◽

Equilibrative Nucleoside Transporters ◽

Negligible Contribution

Download Full-text

Combinatorial targeting of microRNA-26b and microRNA-101 exerts a synergistic inhibition on cyclooxygenase-2 in brain metastatic triple-negative breast cancer cells

Breast Cancer Research and Treatment ◽

10.1007/s10549-021-06255-y ◽

2021 ◽

Author(s):

Rania Harati ◽

Aloïse Mabondzo ◽

Abdelaziz Tlili ◽

Ghalia Khoder ◽

Mona Mahfood ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Cyclooxygenase 2 ◽

Synergistic Inhibition

Download Full-text

Preferential uptake of antibody targeted calcium phosphosilicate nanoparticles by metastatic triple negative breast cancer cells in co-cultures of human metastatic breast cancer cells plus bone osteoblasts

Nanomedicine Nanotechnology Biology and Medicine ◽

10.1016/j.nano.2021.102383 ◽

2021 ◽

Vol 34 ◽

pp. 102383

Author(s):

Karen M. Bussard ◽

Christopher M. Gigliotti ◽

Bernadette M. Adair ◽

Jenna M. Snyder ◽

Nicholas T. Gigliotti ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Metastatic Breast ◽

Calcium Phosphosilicate ◽

Preferential Uptake

Download Full-text

MicroRNA-543 inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of triple-negative breast cancer cells via down-regulation of ACTL6A gene

Clinical & Translational Oncology ◽

10.1007/s12094-021-02672-z ◽

2021 ◽

Author(s):

Y. L. Wang ◽

R. H. Liang ◽

C. Y. Wang ◽

R. P. Zhang ◽

S. Y. Wu ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Epithelial Mesenchymal Transition ◽

Down Regulation ◽

Mesenchymal Transition

Download Full-text

5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00267 ◽

2021 ◽

Author(s):

Mingming Wei ◽

Yunyun Zhou ◽

Chong Li ◽

Yuyu Yang ◽

Tongtong Liu ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Annexin A2

Download Full-text