FPI profiles in a European sample of 1068 female patients suffering from anorexia or bulimia nervosa

Abstract The bulimia nervosa (BN) is one of the psychiatric disorders, which pathophysiology is not clear currently. Recent studies have concentrated on brain structural and functional changes in BN patients. However, findings have been inconsistent.The aim of this study was to explore the relationships between brain structural alterations and clinical features in Chinese female patients with BN.Method A total of 34 female patients with BN and 34 matched healthy controls (HC) underwent a T1-weighted magnetic resonance imaging (MRI) scanning. VBM analysis was carried out by using SPM8 ( http://www.fil.ion.ucl.ac.uk/spm/software/spm8/ ) to explore the alterations of regional Grey Matter Volume (GMV). The correlation analysis was performed using Statistical Package for the Social Sciences (SPSS) .Results The BN group showed reduced regional grey matter volume of the left medial superior frontal gyrus (SFGmed.L), the right superior temporal gyrus (STG.R), the right median cingulate and paracingulate gyri (DCG.R), the left median cingulate and paracingulate gyri (DCG.L) and the left dorsolateral superior frontal gyrus (SFGdor.L) compared to HC. There was no significantly regional grey matter volume increase in BN patients. The brain areas that GMV altered were uncorrelated with BMI and duration of illness (p>0.05). There was a significantly negtive correlation between age and GMV in the SFGmed.L (P<0.005, r=-0.516), the DCG.R (P<0.005, r=-0.556), the DCG.L (P<0.05, r=-0.576) and the SFGdor.L (P<0.005,r=-0.576). The self-esteem and self-evaluation of BN patients were uncorrelated with the structural alterations of GMV.Conlusions The results show altered regional GMV in females with bulimia nervosa in several brain areas, but it difficult to differentiate whether the GMV changes are the results of BN pathology or the consequences of binge-eating and compensatory behaviour. The structural alterations might be associated with impairments of inhibitory control and body dissatisfaction in BN patients, as well as mood disorder comorbidity.

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Altered regional gray matter volume in Chinese female patients with bulimia nervosa

10.21203/rs.2.17263/v2 ◽

2020 ◽

Author(s):

Xiao Li ◽

Xiaowei Liu ◽

Yu Wang ◽

Lingfei Li ◽

Linli Zheng ◽

...

Keyword(s):

Bulimia Nervosa ◽

Grey Matter ◽

Grey Matter Volume ◽

Brain Areas ◽

Structural Alterations ◽

Superior Frontal Gyrus ◽

Functional Changes ◽

Female Patients ◽

Matter Volume ◽

The Right

Abstract Background The bulimia nervosa (BN) is one of the psychiatric disorders, which pathophysiology is not clear currently. Recent studies have concentrated on brain structural and functional changes in BN patients. However, findings have been inconsistent.The aim of this study was to explore the relationships between brain structural alterations and clinical features in Chinese female patients with BN. Method A total of 34 female patients with BN and 34 matched healthy controls (HC) underwent a T1-weighted magnetic resonance imaging (MRI) scanning. VBM analysis was carried out by using SPM8 ( http://www.fil.ion.ucl.ac.uk/spm/software/spm8/ ) to explore the alterations of regional Grey Matter Volume (GMV). The correlation analysis was performed using Statistical Package for the Social Sciences (SPSS) . Results The BN group showed reduced regional grey matter volume of the left medial superior frontal gyrus (SFGmed.L), the right superior temporal gyrus (STG.R), the right median cingulate and paracingulate gyri (DCG.R), the left median cingulate and paracingulate gyri (DCG.L) and the left dorsolateral superior frontal gyrus (SFGdor.L) compared to HC. There was no significantly regional grey matter volume increase in BN patients. The brain areas that GMV altered were uncorrelated with BMI and duration of illness (p>0.05). There was a significantly negtive correlation between age and GMV in the SFGmed.L (P<0.005, r=-0.516), the DCG.R (P<0.005, r=-0.556), the DCG.L (P<0.05, r=-0.576) and the SFGdor.L (P<0.005,r=-0.576). The self-esteem and self-evaluation of BN patients were uncorrelated with the structural alterations of GMV. Conlusions The results show altered regional GMV in females with bulimia nervosa in several brain areas, but it difficult to differentiate whether the GMV changes are the results of BN pathology or the consequences of binge-eating and compensatory behaviour. The structural alterations might be associated with impairments of inhibitory control and body dissatisfaction in BN patients, as well as mood disorder comorbidity.

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No changes in serum ghrelin levels in female patients with bulimia nervosa

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2004.06.012 ◽

2004 ◽

Vol 28 (7) ◽

pp. 1181-1184 ◽

Cited By ~ 18

Author(s):

Michiko Nakazato ◽

Kenji Hashimoto ◽

Akihiro Shiina ◽

Hiroki Koizumi ◽

Makoto Mitsumoti ◽

...

Keyword(s):

Bulimia Nervosa ◽

Female Patients ◽

Serum Ghrelin

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Altered regional gray matter volume in Chinese female patients with bulimia nervosa

10.21203/rs.2.17263/v3 ◽

2020 ◽

Author(s):

Xiao Li ◽

Xiaowei Liu ◽

Yu Wang ◽

Lingfei Li ◽

Linli Zheng ◽

...

Keyword(s):

Bulimia Nervosa ◽

Grey Matter ◽

Grey Matter Volume ◽

Brain Areas ◽

Structural Alterations ◽

Superior Frontal Gyrus ◽

Functional Changes ◽

Female Patients ◽

Matter Volume ◽

The Right

Abstract Background The bulimia nervosa (BN) is one of the psychiatric disorders, which pathophysiology is not clear currently. Recent studies have concentrated on brain structural and functional changes in BN patients. However, findings have been inconsistent.The aim of this study was to explore the relationships between brain structural alterations and clinical features in Chinese female patients with BN. Method A total of 34 female patients with BN and 34 matched healthy controls (HC) underwent a T1-weighted magnetic resonance imaging (MRI) scanning. VBM analysis was carried out by using SPM8 ( http://www.fil.ion.ucl.ac.uk/spm/software/spm8/ ) to explore the alterations of regional Grey Matter Volume (GMV). The correlation analysis was performed using Statistical Package for the Social Sciences (SPSS) . Results The BN group showed reduced regional grey matter volume of the left medial superior frontal gyrus (SFGmed.L), the right superior temporal gyrus (STG.R), the right median cingulate and paracingulate gyri (DCG.R), the left median cingulate and paracingulate gyri (DCG.L) and the left dorsolateral superior frontal gyrus (SFGdor.L) compared to HC. There was no significantly regional grey matter volume increase in BN patients. The brain areas that GMV altered were uncorrelated with BMI and duration of illness (p>0.05). There was a significantly negtive correlation between age and GMV in the SFGmed.L (P<0.005, r=-0.516), the DCG.R (P<0.005, r=-0.556), the DCG.L (P<0.05, r=-0.576) and the SFGdor.L (P<0.005,r=-0.576). The self-esteem and self-evaluation of BN patients were uncorrelated with the structural alterations of GMV. Conclusions The results show altered regional GMV in females with bulimia nervosa in several brain areas, but it difficult to differentiate whether the GMV changes are the results of BN pathology or the consequences of binge-eating and compensatory behaviour. The structural alterations might be associated with impairments of inhibitory control and body dissatisfaction in BN patients, as well as mood disorder comorbidity.

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