EMOTIONAL DYSREGULATION AND ATTACHMENT DIMENSIONS IN FEMALE PATIENTS WITH BULIMIA NERVOSA

Abstract The bulimia nervosa (BN) is one of the psychiatric disorders, which pathophysiology is not clear currently. Recent studies have concentrated on brain structural and functional changes in BN patients. However, findings have been inconsistent.The aim of this study was to explore the relationships between brain structural alterations and clinical features in Chinese female patients with BN.Method A total of 34 female patients with BN and 34 matched healthy controls (HC) underwent a T1-weighted magnetic resonance imaging (MRI) scanning. VBM analysis was carried out by using SPM8 ( http://www.fil.ion.ucl.ac.uk/spm/software/spm8/ ) to explore the alterations of regional Grey Matter Volume (GMV). The correlation analysis was performed using Statistical Package for the Social Sciences (SPSS) .Results The BN group showed reduced regional grey matter volume of the left medial superior frontal gyrus (SFGmed.L), the right superior temporal gyrus (STG.R), the right median cingulate and paracingulate gyri (DCG.R), the left median cingulate and paracingulate gyri (DCG.L) and the left dorsolateral superior frontal gyrus (SFGdor.L) compared to HC. There was no significantly regional grey matter volume increase in BN patients. The brain areas that GMV altered were uncorrelated with BMI and duration of illness (p>0.05). There was a significantly negtive correlation between age and GMV in the SFGmed.L (P<0.005, r=-0.516), the DCG.R (P<0.005, r=-0.556), the DCG.L (P<0.05, r=-0.576) and the SFGdor.L (P<0.005,r=-0.576). The self-esteem and self-evaluation of BN patients were uncorrelated with the structural alterations of GMV.Conlusions The results show altered regional GMV in females with bulimia nervosa in several brain areas, but it difficult to differentiate whether the GMV changes are the results of BN pathology or the consequences of binge-eating and compensatory behaviour. The structural alterations might be associated with impairments of inhibitory control and body dissatisfaction in BN patients, as well as mood disorder comorbidity.

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Altered regional gray matter volume in Chinese female patients with bulimia nervosa

10.21203/rs.2.17263/v2 ◽

2020 ◽

Author(s):

Xiao Li ◽

Xiaowei Liu ◽

Yu Wang ◽

Lingfei Li ◽

Linli Zheng ◽

...

Keyword(s):

Bulimia Nervosa ◽

Grey Matter ◽

Grey Matter Volume ◽

Brain Areas ◽

Structural Alterations ◽

Superior Frontal Gyrus ◽

Functional Changes ◽

Female Patients ◽

Matter Volume ◽

The Right

Abstract Background The bulimia nervosa (BN) is one of the psychiatric disorders, which pathophysiology is not clear currently. Recent studies have concentrated on brain structural and functional changes in BN patients. However, findings have been inconsistent.The aim of this study was to explore the relationships between brain structural alterations and clinical features in Chinese female patients with BN. Method A total of 34 female patients with BN and 34 matched healthy controls (HC) underwent a T1-weighted magnetic resonance imaging (MRI) scanning. VBM analysis was carried out by using SPM8 ( http://www.fil.ion.ucl.ac.uk/spm/software/spm8/ ) to explore the alterations of regional Grey Matter Volume (GMV). The correlation analysis was performed using Statistical Package for the Social Sciences (SPSS) . Results The BN group showed reduced regional grey matter volume of the left medial superior frontal gyrus (SFGmed.L), the right superior temporal gyrus (STG.R), the right median cingulate and paracingulate gyri (DCG.R), the left median cingulate and paracingulate gyri (DCG.L) and the left dorsolateral superior frontal gyrus (SFGdor.L) compared to HC. There was no significantly regional grey matter volume increase in BN patients. The brain areas that GMV altered were uncorrelated with BMI and duration of illness (p>0.05). There was a significantly negtive correlation between age and GMV in the SFGmed.L (P<0.005, r=-0.516), the DCG.R (P<0.005, r=-0.556), the DCG.L (P<0.05, r=-0.576) and the SFGdor.L (P<0.005,r=-0.576). The self-esteem and self-evaluation of BN patients were uncorrelated with the structural alterations of GMV. Conlusions The results show altered regional GMV in females with bulimia nervosa in several brain areas, but it difficult to differentiate whether the GMV changes are the results of BN pathology or the consequences of binge-eating and compensatory behaviour. The structural alterations might be associated with impairments of inhibitory control and body dissatisfaction in BN patients, as well as mood disorder comorbidity.

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Mediational Links for the Severity of Anorexia and Bulimia a Path Analysis Study

10.21203/rs.3.rs-489720/v1 ◽

2021 ◽

Author(s):

Geovanny Genaro Reivan Ortiz ◽

Roser Granero Perez ◽

Patricia Ortiz Rodas

Keyword(s):

Bulimia Nervosa ◽

Path Analysis ◽

Goodness Of Fit ◽

Positive Association ◽

Emotional Dysregulation ◽

Clinical Population ◽

Analysis Model ◽

Predictive Capacity ◽

Starting Point ◽

Place Of Origin

Abstract Background: to date there is empirical evidence on the associations between anorexia and bulimia nervosa with psychopathological constructs (anxiety, depression, perfectionism, emotional dysregulation) and sociodemographic characteristics (gender and place of origin). However, there are no studies that analyze the underlying mechanisms between these variables, which allow estimating the direct and indirect effects, including the possible mediational relationships in causal models of path analysis. Method: the study had a sample of 918 Ecuadorian university students from three places of origin. Results: The causal path analysis model indicates a significant and positive association between the variables depending on the place of origin of the participants. Likewise, the model obtained an adequate goodness of fit and good predictive capacity. Conclusions: The data suggest that the model of underlying relationships between the study variables for the risk of ED, anorexia nervosa and bulimia nervosa, is different depending on the place of origin. It is indicated for future studies to estimate the criterion in the clinical population and with repetitive measures over time. We believe that the study will provide a starting point in the design, implementation and evaluation of prevention programs for eating disorders at the primary action levels.

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