Reply to Comment on Plugge et al. 2021 “Toward a Universal Acute Fish Threshold of Toxicological Concern”

2021 ◽  
Vol 40 (9) ◽  
pp. 2382-2383
Author(s):  
Hans Plugge ◽  
Nihar Das ◽  
Jakub Kostal
Keyword(s):  
Threshold Of Toxicological Concern

Inhalation threshold of toxicological concern (TTC) — Structural alerts discriminate high from low repeated-dose inhalation toxicity

2016 ◽  
Vol 88 ◽  
pp. 123-132 ◽  
Author(s):  
Gerrit Schüürmann ◽  
Ralf-Uwe Ebert ◽  
Inga Tluczkiewicz ◽  
Sylvia E. Escher ◽  
Ralph Kühne
Keyword(s):  
Repeated Dose ◽  
Inhalation Toxicity ◽  
Structural Alerts ◽  
Threshold Of Toxicological Concern ◽  
Dose Inhalation

scholarly journals Application of the Threshold of Toxicological Concern (TTC) in Food Safety: Challenges and Opportunities

2021 ◽  
Vol 3 ◽  
Author(s):  
Rositsa Serafimova ◽  
Tamara Coja ◽  
George E. N. Kass
Keyword(s):  
Food Safety ◽  
Plant Protection ◽  
Plant Protection Products ◽  
The European Union ◽  
Use Of Data ◽  
Challenges And Opportunities ◽  
Guidance Documents ◽  
Threshold Of Toxicological Concern ◽  
Active Substances

The safety assessment of chemicals added or found in food has traditionally made use of data from in vivo studies performed on experimental animals. The nature and amount of data required to carry out a risk assessment is generally stipulated either in the different food legislations or in sectoral guidance documents. However, there are still cases where no or only limited experimental data are available or not specified by law, for example for contaminants or for some minor metabolites from active substances in plant protection products. For such cases, the Threshold of Toxicological Concern (TTC) can be applied. This review explores the use of the TTC approach in food safety in the European Union, in relation to the different food sectors, legal requirements and future opportunities.

scholarly journals The TTC Data Mart: An interactive browser for threshold of toxicological concern calculations

2020 ◽  
Vol 15 ◽  
pp. 100128
Author(s):  
Chantel I. Nicolas ◽  
Kevin Bronson ◽  
Salil N. Pendse ◽  
Alina Efremenko ◽  
Jeremy M. Fitzpatrick ◽  
...  
Keyword(s):  
Data Mart ◽  
Threshold Of Toxicological Concern

scholarly journals Guidance on the use of the Threshold of Toxicological Concern approach in food safety assessment

EFSA Journal ◽  
2019 ◽  
Vol 17 (6) ◽  
Author(s):  
◽  
Simon J More ◽  
Vasileios Bampidis ◽  
Diane Benford ◽  
Claude Bragard ◽  
...  
Keyword(s):  
Food Safety ◽  
Safety Assessment ◽  
Threshold Of Toxicological Concern

A new paradigm in threshold of toxicological concern based on chemoinformatics analysis of a highly curated database enriched with antimicrobials

2020 ◽  
Vol 143 ◽  
pp. 111561 ◽  
Author(s):  
Chihae Yang ◽  
Mitchell Cheeseman ◽  
James Rathman ◽  
Aleksandra Mostrag ◽  
Nicholas Skoulis ◽  
...  
Keyword(s):  
New Paradigm ◽  
Threshold Of Toxicological Concern

scholarly journals The Threshold of Toxicological Concern Concept in Risk Assessment

2005 ◽  
Vol 86 (2) ◽  
pp. 226-230 ◽  
Author(s):  
R. Kroes ◽  
J. Kleiner ◽  
A. Renwick
Keyword(s):  
Risk Assessment ◽  
Threshold Of Toxicological Concern
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