scholarly journals Two distinct types of nodes of Ranvier support auditory nerve function in the mouse cochlea

Glia ◽  
2021 ◽  
Author(s):  
Clarisse H. Panganiban ◽  
Jeremy L. Barth ◽  
Junying Tan ◽  
Kenyaria V. Noble ◽  
Carolyn M. McClaskey ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Nerve Function ◽  
Nodes Of Ranvier

scholarly journals Two distinct types of nodes of Ranvier support auditory nerve function in the mouse cochlea

2021 ◽  
Author(s):  
Clarisse H. Panganiban ◽  
Jeremy L. Barth ◽  
Junying Tan ◽  
Kenyaria V. Noble ◽  
Carolyn M. McClaskey ◽  
...  
Keyword(s):  
Glial Cells ◽  
Auditory Nerve ◽  
Nerve Function ◽  
Nodes Of Ranvier ◽  
Age Related ◽  
Hearing Function ◽  
Function Correlation ◽  
Age Related Hearing Loss ◽  
Distinct Features ◽  
Node Development

AbstractGlial cells of the auditory nerve regulate formation of the nodes of Ranvier that are needed for regeneration of action potentials and proper hearing function. Here we identify and describe the distinct features of two novel types of Ranvier nodes—the axonal node and the ganglion node—in the mouse auditory nerve that change across the lifespan, including during myelination and postnatal development, and degenerate during aging. Cellular, molecular, and structure-function correlation evaluations revealed that nodal types are critical for different aspects of auditory nerve function. Specifically, the length of the axonal node is associated with neural processing speed and neural synchrony, whereas ganglion node development is associated with amplitude growth of the action potential. Moreover, our data indicate that dysregulation of glial cells and associated degeneration of the ganglion node structure are an important and new mechanism of auditory nerve dysfunction in age-related hearing loss.

Neural Presbyacusis in Humans Inferred from Age-Related Differences in Auditory Nerve Function and Structure

2021 ◽  
pp. JN-RM-1747-21
Author(s):  
Kelly C. Harris ◽  
Jayne B. Ahlstrom ◽  
James W. Dias ◽  
Lilyana B. Kerouac ◽  
Carolyn M. McClaskey ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Nerve Function ◽  
Age Related

Adverse effects of topical papaverine on auditory nerve function

2008 ◽  
Vol 150 (9) ◽  
pp. 901-909 ◽  
Author(s):  
Geraldine M. Chadwick ◽  
Anthony L. Asher ◽  
Craig A. Van Der Veer ◽  
Richard J. Pollard
Keyword(s):  
Adverse Effects ◽  
Auditory Nerve ◽  
Nerve Function

Auditory nerve function following cochleitis

2012 ◽  
Vol 76 (11) ◽  
pp. 1696-1701 ◽  
Author(s):  
Jessica Levi ◽  
Liesl Looney ◽  
Ryan Murray ◽  
Yell Inverso ◽  
Robert C. O’Reilly ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Nerve Function

Surgery for sporadic vestibular schwannoma. Part III: Facial and auditory nerve function

2015 ◽  
Vol 49 (6) ◽  
pp. 373-380 ◽  
Author(s):  
Przemysław Kunert ◽  
Tomasz Dziedzic ◽  
Anna Podgórska ◽  
Tomasz Czernicki ◽  
Arkadiusz Nowak ◽  
...  
Keyword(s):  
Vestibular Schwannoma ◽  
Auditory Nerve ◽  
Nerve Function

Evaluation of a Novel, Noninvasive, Objective Test of Auditory Nerve Function in Paediatric Cochlear Implant Candidates

2010 ◽  
Vol 11 (sup1) ◽  
pp. 421-425
Author(s):  
A Hirschfelder ◽  
S Gräbel ◽  
CH Scheiber ◽  
H Olze
Keyword(s):  
Cochlear Implant ◽  
Auditory Nerve ◽  
Objective Test ◽  
Nerve Function

scholarly journals The sensitivity of different methods for detecting abnormalities in auditory nerve function

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Tianhao Lu ◽  
Qiang Li ◽  
Chen Zhang ◽  
Min Chen ◽  
Zhengming Wang ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Nerve Function

scholarly journals Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs

2007 ◽  
Vol 25 (2) ◽  
pp. 309-318 ◽  
Author(s):  
Jun Maruyama ◽  
Takahiko Yamagata ◽  
Mats Ulfendahl ◽  
Göran Bredberg ◽  
Richard A. Altschuler ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Guinea Pigs ◽  
Nerve Function
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