Weight loss in Alzheimer’s disease, vascular dementia and dementia with Lewy bodies: Impact on mortality and hospitalization by dementia subtype

Author(s):  
Pinar Soysal ◽  
Semen Gokce Tan ◽  
Marianna Rogowska ◽  
Sana Jawad ◽  
Lee Smith ◽  
...  
Neurology ◽  
2000 ◽  
Vol 54 (8) ◽  
pp. 1616-1625 ◽  
Author(s):  
M. P. Walker ◽  
G. A. Ayre ◽  
J. L. Cummings ◽  
K. Wesnes ◽  
I. G. McKeith ◽  
...  

1999 ◽  
Vol 174 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Clive Holmes ◽  
Nigel Cairns ◽  
Peter L. Lantos ◽  
Anthony Mann

BackgroundFollowing the success of the NINCDS–ADRDA criteria for Alzheimer's disease, groups interested in vascular dementia and dementia with Lewy bodies have now adopted similar criteria.AimsTo assess whether the validity of these criteria are influenced by the prevalence of mixed pathologies or by the prevalence rate.MethodA community based postmortem study.ResultsMixed pathologies were common (33.8%). The high specificities obtained for the CDLB and NINDS–AIREN criteria (1.00 and 0.95, respectively) were associated with low sensitivities (0.22 and 0.43, respectively). Low prevalence and the presence of mixed pathologies had a deleterious effect on positive predictive values.ConclusionsCurrent clinical diagnostic criteria are good at detecting pathology per se but not at detecting pure pathology. A large proportion of subjects from the general population fulfilling probable CDLB, probable NINCDS–ADRDA or probable NINDS–AIREN will have mixed pathologies.


2014 ◽  
Vol 86 (11) ◽  
pp. 1248-1252 ◽  
Author(s):  
Yasuhiro Nagahama ◽  
Tomoko Okina ◽  
Norio Suzuki

IntroductionTo examine whether imitation of gestures provided useful information to diagnose early dementia in elderly patients.MethodsImitation of finger and hand gestures was evaluated in patients with mild dementia; 74 patients had dementia with Lewy bodies (DLB), 100 with Alzheimer's disease (AD) and 52 with subcortical vascular dementia (SVaD).ResultsSignificantly, more patients with DLB (32.4%) compared with patients with AD (5%) or SVaD (11.5%) had an impaired ability to imitate finger gestures bilaterally. Also, significantly, more patients with DLB (36.5%) compared with patients with AD (5%) or SVaD (15.4%) had lower mean scores of both hands. In contrast, impairment of the imitation of bimanual gestures was comparable among the three patient groups (DLB 50%, AD 42%, SVaD 42.3%).DiscussionOur study revealed that imitation of bimanual gestures was impaired non-specifically in about half of the patients with mild dementia, whereas imitation of finger gestures was significantly more impaired in patients with early DLB than in those with AD or SVaD. Although the sensitivity was not high, the imitation tasks may provide additional information for diagnosis of mild dementia, especially for DLB.


2010 ◽  
Vol 119 (5) ◽  
pp. 579-589 ◽  
Author(s):  
Masafumi Ihara ◽  
Tuomo M. Polvikoski ◽  
Ros Hall ◽  
Janet Y. Slade ◽  
Robert H. Perry ◽  
...  

2015 ◽  
Vol 16 (5) ◽  
pp. 305-314 ◽  
Author(s):  
Toshie Manabe ◽  
Katsuyoshi Mizukami ◽  
Hiroyasu Akatsu ◽  
Shinji Teramoto ◽  
Kazue Yamaoka ◽  
...  

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