scholarly journals Antibiotic prophylaxis in clean-contaminated head and neck cases with microvascular free flap reconstruction: A systematic review and meta-analysis

Head & Neck ◽  
2017 ◽  
Vol 40 (2) ◽  
pp. 417-427 ◽  
Author(s):  
Yarah M. Haidar ◽  
Prem B. Tripathi ◽  
Tjoson Tjoa ◽  
Sartaaj Walia ◽  
Lishi Zhang ◽  
...  
Oral Oncology ◽  
2021 ◽  
Vol 113 ◽  
pp. 105117
Author(s):  
Kevin Chorath ◽  
Beatrice Go ◽  
Justin R. Shinn ◽  
Leila J. Mady ◽  
Seerat Poonia ◽  
...  

Head & Neck ◽  
2020 ◽  
Vol 42 (8) ◽  
pp. 2165-2180 ◽  
Author(s):  
Ainiwaer Mijiti ◽  
Nazuke Kuerbantayi ◽  
Zhi Q. Zhang ◽  
Ming Y. Su ◽  
Xiao H. Zhang ◽  
...  

2020 ◽  
Vol 1-2 ◽  
pp. 21-26
Author(s):  
David D. Krijgh ◽  
Milou M.E. van Straeten ◽  
Marc A.M. Mureau ◽  
Antonius J.M. Luijsterburg ◽  
Pascal P.A. Schellekens ◽  
...  

2018 ◽  
Vol 4 (1) ◽  
pp. 39-42 ◽  
Author(s):  
Phoebe K. Yu ◽  
Rosh K.V. Sethi ◽  
Vinay Rathi ◽  
Sidharth V. Puram ◽  
Derrick T. Lin ◽  
...  

2017 ◽  
Vol 78 (04) ◽  
pp. 337-345 ◽  
Author(s):  
Kurren Gill ◽  
David Hsu ◽  
Gurston Nyquist ◽  
Howard Krein ◽  
Jurij Bilyk ◽  
...  

Objective Naso- or orbitocutaneous fistula (NOF) is a challenging complication of orbital exenteration, and it often requires surgical repair. We sought to identify the incidence and risk factors for NOF after orbital exenteration. Study Design Retrospective chart review, systematic review, meta-analysis. Setting Tertiary care center. Participants Patients undergoing free flap reconstruction following orbital exenteration. Records were reviewed for clinicopathologic data, operative details, and outcomes. Main Outcome Measures Univariate analysis was used to assess risk factors for incidence of postoperative NOF. PubMed and Cochrane databases were searched for published reports on NOF after orbital exenteration. Rates of fistula and odds ratios for predictive factors were compared in a meta-analysis. Results Total 7 of 77 patients (9.1%) developed NOF; fistula formation was associated with ethmoid sinus involvement (p < 0.05) and minor wound break down (p < 0.05). On meta-analysis, pooled rates of fistula formation were 5.8% for free flap patients and 12.5% for patients receiving no reconstruction. Conclusion Immediate postoperative wound complications and medial orbital wall resection increased the risk for NOF. On review and meta-analysis, reconstruction of orbital exenteration defects decreased the risk for fistula formation, but published series did not demonstrate a significant decrease in risk with free flaps compared with other methods of reconstruction.


Author(s):  
J Daly ◽  
P Gearing ◽  
N Tang ◽  
A Ramakrishnan ◽  
K P Singh

Abstract Background Adherence to guidelines for antibiotic prophylaxis is often poor and is an important target for antimicrobial stewardship programs. Prescribing audits that suggested poor adherence to guidelines in a plastic surgery department led to a targeted education program to bring antibiotic prescriptions in line with hospital guidelines. We reviewed whether this intervention was associated with changed perioperative prescribing and altered surgical outcomes, including the rate of surgical site infections, specifically looking at clean-contaminated head and neck tumour resections with free flap reconstruction. Methods A retrospective cohort study was performed on 325 patients who underwent clean-contaminated head and neck tumour resection and free flap reconstruction from January 1, 2013 to February 19, 2019. Patients were divided into two groups, those before (pre-intervention) and after (post-intervention) the education campaign. We analysed patient demographic and disease characteristics, intraoperative and postoperative factors and surgical outcomes. Results Patients pre-intervention were prescribed longer courses of prophylactic antibiotics (median = 9 [interquartile range = 8] vs. median = 1 [interquartile range = 1], p &lt; 0.001), more topical chloramphenicol ointment (21.82% vs. 0%, p &lt; 0.001) and more oral nystatin (36.9% vs. 12.2%, p &lt; 0.001). Patients post-intervention had higher rates of recipient infections (36.11% vs. 17.06%, p &lt; 0.001) and donor site infections (6.94% vs. 1.19%, p = 0.006). Conclusion Following the education campaign, patients were prescribed shorter courses of prophylactic antibiotics, more of the recommended cefazolin-metronidazole regimen and less use of topical antibiotics. However, patients also had a higher rate of surgical site infections.


2016 ◽  
Vol 127 (2) ◽  
pp. 325-330 ◽  
Author(s):  
Eric T. Carniol ◽  
Emily Marchiano ◽  
Jacob S. Brady ◽  
Aziz M. Merchant ◽  
Jean Anderson Eloy ◽  
...  

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