The RNA genome of hepatitis E virus robustly triggers an antiviral interferon response

Hepatology ◽  
2018 ◽  
Vol 67 (6) ◽  
pp. 2096-2112 ◽  
Author(s):  
Wenshi Wang ◽  
Yijin Wang ◽  
Changbo Qu ◽  
Shan Wang ◽  
Jianhua Zhou ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Interferon Response ◽  
Rna Genome

The RNA genome of hepatitis E virus robustly triggers antiviral interferon response

2018 ◽  
Vol 68 ◽  
pp. S794
Author(s):  
W. Wang ◽  
Y. Wang ◽  
C. Qu ◽  
S. Wang ◽  
M. Peppelenbosch ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Interferon Response ◽  
Rna Genome

scholarly journals Evidence that the Genomic RNA of Hepatitis E Virus Is Capped

1999 ◽  
Vol 73 (10) ◽  
pp. 8848-8850 ◽  
Author(s):  
Yamina Kabrane-Lazizi ◽  
Xiang-Jin Meng ◽  
Robert H. Purcell ◽  
Suzanne U. Emerson
Keyword(s):  
Monoclonal Antibody ◽  
Reverse Transcription ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Genomic Rna ◽  
Pcr Assay ◽  
Reverse Transcription Pcr ◽  
Replication Strategy ◽  
Positive Sense ◽  
Rna Genome

ABSTRACT Hepatitis E virus (HEV) is an unclassified virus with a positive-sense RNA genome and an undefined replication strategy. In order to determine whether the HEV genome is capped or not, we developed a reverse transcription-PCR assay that is based on the ability of a monoclonal antibody to recognize 7-methylguanosine (m7G). Antibody to m7G bound RNA extracted from virions of two different HEV genotypes. The cap analog competitively inhibited the binding of virion RNAs, demonstrating that HEV has a capped RNA genome.

scholarly journals Hepatitis E virus infection activates NLRP3 inflammasome antagonizing interferon response but therapeutically targetable

Hepatology ◽  
2021 ◽  
Author(s):  
Yang Li ◽  
Peifa Yu ◽  
Amy L. Kessler ◽  
Jingyi Shu ◽  
Xiaoyan Liu ◽  
...  
Keyword(s):  
Virus Infection ◽  
Nlrp3 Inflammasome ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Interferon Response

scholarly journals Hepatitis E virus persists in the presence of a type III interferon response

2017 ◽  
Vol 13 (5) ◽  
pp. e1006417 ◽  
Author(s):  
Xin Yin ◽  
Xinlei Li ◽  
Charuta Ambardekar ◽  
Zhimin Hu ◽  
Sébastien Lhomme ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Interferon Response ◽  
Type Iii ◽  
Type Iii Interferon

P0488 : Dissecting the complexity of interferon response that cross talks with 4E-BP1 in hepatitis E virus infection

2015 ◽  
Vol 62 ◽  
pp. S497
Author(s):  
X. Zhou ◽  
L. Xu ◽  
W. Wang ◽  
H. Blokzijl ◽  
Y. Wang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Interferon Response

scholarly journals Hepatitis E Virus ORF2 Inhibits RIG-I Mediated Interferon Response

2020 ◽  
Vol 11 ◽  
Author(s):  
Smita Hingane ◽  
Nishant Joshi ◽  
Milan Surjit ◽  
C. T. Ranjith-Kumar
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Interferon Response

Prevalence of antibodies and RNA genome of hepatitis E virus in a cohort of French immunocompromised

2012 ◽  
Vol 53 (4) ◽  
pp. 346-349 ◽  
Author(s):  
Sarah Maylin ◽  
Robin Stephan ◽  
Jean-Michel Molina ◽  
Marie-Noelle Peraldi ◽  
Catherine Scieux ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Rna Genome

Hepatitis E Virus in LeberBiopsien von Patienten mit akuter Hepatitis unbekannter Ätiologie

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
C Dorloff ◽  
J Hemberger ◽  
M Odenthal ◽  
H Holzmann ◽  
S Aberle ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E

Severe course of Hepatitis E Virus infection in a patient with pre-existing autoimmune liver disease

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
S Schlosser ◽  
J Pflaum ◽  
K Weigand ◽  
JJ Wenzel ◽  
W Jilg ◽  
...  
Keyword(s):  
Liver Disease ◽  
Virus Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Autoimmune Liver Disease
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