scholarly journals Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation

2018 ◽  
Vol 2 (7) ◽  
pp. 845-860 ◽  
Author(s):  
Morgan Preziosi ◽  
Hirohisa Okabe ◽  
Minakshi Poddar ◽  
Sucha Singh ◽  
Satdarshan P. Monga
Keyword(s):  
Liver Zonation ◽  
Murine Liver

scholarly journals Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Ruihua Ma ◽  
Angelica S Martínez-Ramírez ◽  
Thomas L Borders ◽  
Fanding Gao ◽  
Beatriz Sosa-Pineda
Keyword(s):  
Spatial Distribution ◽  
Transgenic Mouse Model ◽  
Acute Injury ◽  
Adult Liver ◽  
Metabolic Functions ◽  
Liver Zonation ◽  
Metabolic Zonation ◽  
Wnt Ligands ◽  
Murine Liver ◽  
Zonation Patterns

The distribution of complementary metabolic functions in hepatocytes along a portocentral axis is called liver zonation. Endothelial secreted Wnt ligands maintain metabolic zonation in the adult murine liver but whether those ligands are necessary to initiate zonation in the immature liver has been only partially explored. Also, numerous non-metabolic proteins display zonated expression in the adult liver but it is not entirely clear if their localization requires endothelial Wnts. Here we used a novel transgenic mouse model to compare the spatial distribution of zonated non-metabolic proteins with that of typical zonated metabolic enzymes during liver maturation and after acute injury induced by carbon tetrachloride (CCl4). We also investigated how preventing Wnt ligand secretion from endothelial cells affects zonation patterns under homeostasis and after acute injury. Our study demonstrates that metabolic and non-metabolic zonation are established non-synchronously during maturation and regeneration and require multiple endothelial Wnt sources.

scholarly journals NON PARENCHYMAL WNTS REGULATE BETA‐CATENIN SIGNALING IN MURINE LIVER ZONATION AND REGENERATION

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Morgan Preziosi ◽  
Hirohisa Okabe ◽  
Minakshi Poddar ◽  
Sucha Singh ◽  
Satdarshan Monga
Keyword(s):  
Beta Catenin ◽  
Liver Zonation ◽  
Murine Liver

scholarly journals Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 964-976 ◽  
Author(s):  
Jing Yang ◽  
Laura E. Mowry ◽  
Kari Nichole Nejak-Bowen ◽  
Hirohisa Okabe ◽  
Cassandra R. Diegel ◽  
...  
Keyword(s):  
Beta Catenin ◽  
Liver Zonation ◽  
Murine Liver

A novel approach to investigate SIRS derived heart failure using a murine liver transplantation model

2007 ◽  
Vol 55 (S 1) ◽  
Author(s):  
LO Conzelmann ◽  
N Kayhan ◽  
NA Stumpf ◽  
U Gaffga ◽  
AA Peivandi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Transplantation ◽  
Novel Approach ◽  
Murine Liver ◽  
Transplantation Model

JP-8 Jet Fuel Induces CYP2B1, CYP2BE1, and GSTPI but not CYP1A1 in Murine Liver

2001 ◽  
Author(s):  
A. Dudley ◽  
M. M. Peden-Adams ◽  
J. E. Daly ◽  
D. E. Keil
Keyword(s):  
Jet Fuel ◽  
Murine Liver

Murine Liver Myeloid Cell Isolation Protocol

BIO-PROTOCOL ◽  
2015 ◽  
Vol 5 (10) ◽  
Author(s):  
Benoit Stijlemans ◽  
Amanda Sparkes ◽  
Chlo� Abels ◽  
Jiri Keirsse ◽  
Lea Brys ◽  
...  
Keyword(s):  
Myeloid Cell ◽  
Cell Isolation ◽  
Murine Liver

scholarly journals Erratum: Corrigendum: The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

2016 ◽  
Vol 18 (11) ◽  
pp. 1260-1260 ◽  
Author(s):  
Lara Planas-Paz ◽  
Vanessa Orsini ◽  
Luke Boulter ◽  
Diego Calabrese ◽  
Monika Pikiolek ◽  
...  
Keyword(s):  
Liver Zonation
Sign in / Sign up

Export Citation Format

Share Document