Spatial reference memory in GluR-A-deficient mice using a novel hippocampal-dependent paddling pool escape task

Hippocampus ◽  
2004 ◽  
Vol 14 (2) ◽  
pp. 216-223 ◽  
Author(s):  
W.B. Schmitt ◽  
R.M.J. Deacon ◽  
D. Reisel ◽  
R. Sprengel ◽  
P.H. Seeburg ◽  
...  
Keyword(s):  
Reference Memory ◽  
Spatial Reference ◽  
Spatial Reference Memory ◽  
Deficient Mice

The basolateral amygdala orexin 1 and 2 receptors’ involvement in modulating spatial reference memory

2019 ◽  
Vol 1704 ◽  
pp. 16-25 ◽  
Author(s):  
Motahareh Rouhi Ardeshiri ◽  
Narges Hosseinmardi ◽  
Esmaeil Akbari
Keyword(s):  
Basolateral Amygdala ◽  
Reference Memory ◽  
Spatial Reference ◽  
Spatial Reference Memory

scholarly journals Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yanhua Zhao ◽  
Lili Huang ◽  
Huan Xu ◽  
Guangxi Wu ◽  
Mengyi Zhu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Young Adult ◽  
Postoperative Cognitive Dysfunction ◽  
Underlying Mechanism ◽  
Reference Memory ◽  
Behavior Changes ◽  
Spatial Reference ◽  
Adult Mice ◽  
Spatial Reference Memory ◽  
Old Mice

Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data about the very young adult individuals are lacking. The present study investigated the spatial reference memory, IL-1β, IL-6, and microglia activation changes in the hippocampus in 2-month-old mice after anesthesia and surgery. We found that hippocampal IL-1βand IL-6 increased at 6 hours after surgery. Microglia were profoundly activated in the hippocampus 6 to 24 hours after surgery. However, no significant behavior changes were found in these mice. These results indicate that although anesthesia and surgery led to neuroinflammation, the latter was insufficient to impair the spatial reference memory of young adult mice.

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