Alterations of BLU, a candidate tumor suppressor gene on chromosome 3p21.3, in human nasopharyngeal carcinoma

2003 ◽  
Vol 106 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Xiao-Qiong Liu ◽  
Han-Kui Chen ◽  
Xiao-Shi Zhang ◽  
Zhi-Gang Pan ◽  
Ang Li ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene ◽  
Human Nasopharyngeal Carcinoma

scholarly journals Functional characterization of a candidate tumor suppressor gene, Mirror Image Polydactyly 1 , in nasopharyngeal carcinoma

2020 ◽  
Vol 146 (10) ◽  
pp. 2891-2900 ◽  
Author(s):  
Merrin M.L. Leong ◽  
Arthur K.L. Cheung ◽  
Tommy C.T. Kwok ◽  
Maria L. Lung
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Functional Characterization ◽  
Suppressor Gene ◽  
Mirror Image ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

scholarly journals The tumor supressor function of STGC3 and its reduced expression in nasopharyngeal carcinoma

2008 ◽  
Vol 13 (3) ◽  
Author(s):  
Xiu-Sheng He ◽  
Min Deng ◽  
Shuai Yang ◽  
Zhi-Qiang Xiao ◽  
Qiao Luo ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Suppressor ◽  
Western Blot ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Expression Level ◽  
Biological Behavior ◽  
Positive Staining ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

AbstractSTGC3 is a novel candidate tumor suppressor gene that was found to be associated with nasopharyngeal carcinoma (NPC) via the cDNA cloning and RACE processes. The biological function of the STGC3 protein and its expression level in nasopharyngeal carcinoma remain unknown. This study aimed to evaluate the STGC3 protein expression level in NPC and to investigate the inhibitory function of STGC3 as a candidate tumor suppressor gene. We assessed the expression of the STGC3 protein in NPC biopsies and normal control specimens via Western blot and immunohistochemical analysis. The expression of STGC3 as induced by doxycycline (Dox) via a tetracycline (Tet)-regulated system in human nasopharyngeal carcinoma cell line CNE2 was also established, and the effect of STGC3 restoration on the biological behavior of CNE2 was observed. A reduced level of STGC3 expression (0.978 ± 0.213 versus 0.324 ± 0.185, P < 0.05) was detected in NPC versus normal nasopharyngeal tissue by Western blot assay. Immunohistochemical assays for STGC3 detected positive staining in the nuclei and cytoplasm of epithelial cells, and the positive expression rate in NPC, 8 of 21 (38%), was lower than that in normal nasopharynx samples, 16 of 22 (72%). After STGC3 expression was restored, the growth capacity and clone formation potential of CNE2 cells in soft agar were significantly suppressed, and the cell percentage in G0/G1 phase increased, while the percentage of cells entering the S and G2 phases decreased. This indicates that an abnormality in STGC3 expression is associated with nasopharyngeal carcinogenesis and that it may play an important role in controlling cell growth and regulating the cell cycle.

scholarly journals Genetic and Epigenetic Alterations of DLC-1, a Candidate Tumor Suppressor Gene, in Nasopharyngeal Carcinoma

2006 ◽  
Vol 38 (5) ◽  
pp. 349-353 ◽  
Author(s):  
Dan PENG ◽  
Cai-Ping REN ◽  
Hong-Mei YI ◽  
Liang ZHOU ◽  
Xu-Yu YANG ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Epigenetic Alterations ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene
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