Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

2013 ◽  
Vol 133 (7) ◽  
pp. 1732-1742 ◽  
Author(s):  
Christophe Louandre ◽  
Zakaria Ezzoukhry ◽  
Corinne Godin ◽  
Jean-Claude Barbare ◽  
Jean-Claude Mazière ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Dependent Cell

Targeting Inhibition of STAT3 Induces Immunogenic Cell Death of Hepatocellular Carcinoma Cells via Glycolysis Pathway

2021 ◽  
Author(s):  
Ya Li ◽  
Qiuju Han ◽  
Huajun Zhao ◽  
Zhaoyi Pan ◽  
Zhengyang Lei ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Carcinoma Cells ◽  
Immunogenic Cell Death ◽  
Hepatocellular Carcinoma Cells ◽  
Glycolysis Pathway

Resminostat sensitizes hepatocellular carcinoma cells to sorafenib-induced cell death

2016 ◽  
Vol 69 ◽  
pp. S87
Author(s):  
J. Soukupova ◽  
U.U. Urricelqui ◽  
M. Borgmann ◽  
H. Kohlhof ◽  
I. Fabregat
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

GL-V9 induced upregulation and mitochondrial localization of NAG-1 associates with ROS generation and cell death in hepatocellular carcinoma cells

2017 ◽  
Vol 112 ◽  
pp. 49-59 ◽  
Author(s):  
Xiaobo Zhang ◽  
Yue Kang ◽  
Tongxin Huo ◽  
Ran Tao ◽  
Xiaoping Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Carcinoma Cells ◽  
Ros Generation ◽  
Mitochondrial Localization ◽  
Hepatocellular Carcinoma Cells

scholarly journals C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells

2018 ◽  
Vol 37 (1) ◽  
Author(s):  
Shu-Guang Li ◽  
Qian-Wei Shi ◽  
Ling-yan Yuan ◽  
Li-ping Qin ◽  
Yan Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Mirna Clusters

scholarly journals A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0136340 ◽  
Author(s):  
Chun-Te Ho ◽  
Yu-Jia Chang ◽  
Li-Xi Yang ◽  
Po-Li Wei ◽  
Tsan-Zon Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Carcinoma Cells ◽  
Human Hepatocellular Carcinoma ◽  
Hepatocellular Carcinoma Cells ◽  
Human Hepatocellular Carcinoma Cells

P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells

APOPTOSIS ◽  
2011 ◽  
Vol 16 (5) ◽  
pp. 524-535 ◽  
Author(s):  
Tsun Yee Tsang ◽  
Wan Yee Tang ◽  
Judy Yuet Wa Chan ◽  
Ngai Na Co ◽  
Chi Lam Au Yeung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
P Glycoprotein ◽  
Radiation Induced

cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis

2007 ◽  
Vol 292 (5) ◽  
pp. G1337-G1346 ◽  
Author(s):  
Maria Eugenia Guicciardi ◽  
Steven F. Bronk ◽  
Nathan W. Werneburg ◽  
Gregory J. Gores
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Cathepsin B ◽  
Carcinoma Cells ◽  
Inhibitory Protein ◽  
Mapk Activation ◽  
Hepatocellular Carcinoma Cells ◽  
Lysosomal Protease ◽  
Targeted Inhibition ◽  
Induced Apoptosis

Sensitivity to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and the lysosomal pathway of cell death are features of cancer cells. However, it is unknown if TRAIL cytotoxic signaling engages the lysosomal pathway of cell death. Our aim, therefore, was to ascertain if TRAIL killing involves lysosomal permeabilization. TRAIL-induced apoptosis of hepatocellular carcinoma cells (HuH-7, Hep3B) was associated with lysosomal permeabilization, as demonstrated by redistribution of the lysosomal protease cathepsin B into the cytosol. Pharmacological and short hairpin RNA-targeted inhibition of cathepsin B reduced apoptosis. Because cellular FLICE-inhibitory protein (cFLIP) inhibits TRAIL-induced cell death and is frequently overexpressed by human cancers, the ability of cFLIP to prevent lysosomal permeabilization during TRAIL treatment was examined. Enforced long-form cFLIP (cFLIPL) expression reduced release of cathepsin B from lysosomes and attenuated apoptosis. cFLIPL overexpression was also associated with robust p42/44 MAPK activation following exposure to TRAIL. In contrast, cFLIPL overexpression attenuated p38 MAPK activation and had no significant effect on JNK and NF-κB activation. Inhibition of p42/44 MAPK by PD98059 restored TRAIL-mediated lysosomal permeabilization and apoptosis in cFLIP-overexpressing cells. In conclusion, these results demonstrate that lysosomal permeabilization contributes to TRAIL-induced apoptosis of hepatocellular carcinoma cells and suggest that cFLIPL cytoprotection is, in part, due to p42/44 MAPK-dependent inhibition of lysosomal breakdown.

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