Positron emission tomography in neurological and psychiatric disorders

2012 ◽  
Vol 22 (1) ◽  
pp. 2-17 ◽  
Author(s):  
Andrew Newberg ◽  
Daniel Monti ◽  
Aleeze Moss ◽  
Abass Alavi
Keyword(s):  
Positron Emission Tomography ◽  
Psychiatric Disorders ◽  
Emission Tomography ◽  
Positron Emission

Destination of Mental Disorders Through Biochemical and Neuropathological Analysis?

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
P. Falkai
Keyword(s):  
Positron Emission Tomography ◽  
Mental Disorders ◽  
Psychiatric Disorders ◽  
Clinical Symptoms ◽  
Emission Tomography ◽  
Imaging Findings ◽  
Severe Mental Disorders ◽  
Positron Emission ◽  
Dopamine Hypothesis

In the first half of the last century researchers believed that severe mental disorders like schizophrenia have a neuropathological basis. Up to now it has been difficult to prove any consistent core finding for this disorder. Reason for this might be that it is a network disorder and therefore regional specific findings will unlikely be found. Parallel to that describing the dopamine hypothesis of schizophrenia and the catechol amine deficit hypothesis of depression were very helpful for understanding the mechanisms of antipsychotics and antidepressants working in these disorders. Especially the introduction of the positron emission tomography has helped to link symptoms with the transmitter systems. However, none of these findings are specific for schizophrenia or depression. During the talk it will be discussed when the combination of core clinical symptoms, imaging findings and genetic variables are helpful for a future classification of psychiatric disorders.

Sight and Insight: Regional Cerebral Metabolic Activity in Schizophrenia Visualised by Positron Emission Tomography, and Competing Neurodevelopmental Perspectives

1990 ◽  
Vol 156 (5) ◽  
pp. 615-619 ◽  
Author(s):  
John L. Waddington
Keyword(s):  
Positron Emission Tomography ◽  
Psychiatric Disorders ◽  
Dopamine Receptors ◽  
Metabolic Activity ◽  
New Technology ◽  
Emission Tomography ◽  
Brain Dopamine ◽  
The Past ◽  
Positron Emission ◽  
Schizophrenic Patients

Over the past several years there has emerged a family of highly sophisticated but technically complex procedures for the visualisation of a range of cerebral functions in living man (Andreasen, 1988). The images they produce are so beguiling not just because of their potential to give new insights into the pathophysiology and treatment of major psychiatric disorders, but because they convey information through a quite fundamental modality: people are only convinced by what they can see. However, initial applications of such new technology have appeared just as likely to generate new questions and contradictions as to provide answers to current issues. This is readily illustrated by recent studies on the imaging of brain dopamine receptors in schizophrenic patients by positron emission tomography (PET) (see Waddington, 1989a).

scholarly journals Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies

2018 ◽  
Vol 40 (3) ◽  
pp. 342-350 ◽  
Author(s):  
Matthew E. Sloan ◽  
Caroline W. Grant ◽  
Joshua L. Gowin ◽  
Vijay A. Ramchandani ◽  
Bernard Le Foll
Keyword(s):  
Positron Emission Tomography ◽  
Psychiatric Disorders ◽  
Emission Tomography ◽  
Positron Emission

Positron emission tomography as an imaging tool in psychiatric disorders

1989 ◽  
Vol 29 (3) ◽  
pp. 351-352 ◽  
Author(s):  
W.-D. Heiss ◽  
G. Pawlik ◽  
K. Herholz ◽  
B. Szelies ◽  
K. Wienhard
Keyword(s):  
Positron Emission Tomography ◽  
Psychiatric Disorders ◽  
Emission Tomography ◽  
Imaging Tool ◽  
Positron Emission

Positron emission tomography in psychiatric disorders

2011 ◽  
Vol 1228 (1) ◽  
pp. E13-E25 ◽  
Author(s):  
Andrew B. Newberg ◽  
Aleeze S. Moss ◽  
Daniel A. Monti ◽  
Abass Alavi
Keyword(s):  
Positron Emission Tomography ◽  
Psychiatric Disorders ◽  
Emission Tomography ◽  
Positron Emission

Sight and Insight: Brain Dopamine Receptor Occupancy by Neuroleptics Visualised in Living Schizophrenic Patients by Positron Emission Tomography

1989 ◽  
Vol 154 (4) ◽  
pp. 433-436 ◽  
Author(s):  
John L. Waddington
Keyword(s):  
Positron Emission Tomography ◽  
Psychiatric Disorders ◽  
Human Subjects ◽  
Receptor Occupancy ◽  
Biological Psychiatry ◽  
Emission Tomography ◽  
Neurotransmitter Receptors ◽  
Brain Dopamine ◽  
Positron Emission ◽  
Schizophrenic Patients

There can be few more impressive sights in contemporary neuroscience and biological psychiatry than the imaging of neurotransmitter receptors in the brains of living human subjects by positron emission tomography (PET; Sedvall et al, 1986). How has such technology advanced our understanding of the pathophysiology and/or treatment of major psychiatric disorders?

Positron Emission Tomography

2014 ◽  
Author(s):  
Shalini Narayana ◽  
Andrew B. Newberg ◽  
Abass Alavi
Keyword(s):  
Positron Emission Tomography ◽  
Psychiatric Disorders ◽  
Drug Effects ◽  
Emission Tomography ◽  
Aminobutyric Acid ◽  
Receptor Imaging ◽  
Disease Course ◽  
Technical Aspects ◽  
Neurotransmitter Systems ◽  
Positron Emission

This chapter describes the application of positron emission tomography (PET) technology to study neurotransmitter systems. The process of developing radiotracers to study the neurotransmitter systems, namely radioligands and the technical aspects of utilizing these radiotracers in PET imaging, is discussed. Normal distribution of neurotransmitters including dopamine, serotonin, opioids, and γ-aminobutyric acid (GABA), as well as abnormalities of these systems in various neurological and psychiatric disorders, are highlighted. The chapter provides evidence that radioligand imaging has been useful not only in delineating pathophysiological processes in psychiatric disorders, but also in contributing to the diagnosis, prognosis, and disease course, and in assessing drug effects. Recent advances in receptor imaging that are rapidly gaining clinical relevance are also discussed.

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