Sight and Insight: Brain Dopamine Receptor Occupancy by Neuroleptics Visualised in Living Schizophrenic Patients by Positron Emission Tomography

1989 ◽  
Vol 154 (4) ◽  
pp. 433-436 ◽  
Author(s):  
John L. Waddington
Keyword(s):  
Positron Emission Tomography ◽  
Psychiatric Disorders ◽  
Human Subjects ◽  
Receptor Occupancy ◽  
Biological Psychiatry ◽  
Emission Tomography ◽  
Neurotransmitter Receptors ◽  
Brain Dopamine ◽  
Positron Emission ◽  
Schizophrenic Patients

There can be few more impressive sights in contemporary neuroscience and biological psychiatry than the imaging of neurotransmitter receptors in the brains of living human subjects by positron emission tomography (PET; Sedvall et al, 1986). How has such technology advanced our understanding of the pathophysiology and/or treatment of major psychiatric disorders?

Sight and Insight: Regional Cerebral Metabolic Activity in Schizophrenia Visualised by Positron Emission Tomography, and Competing Neurodevelopmental Perspectives

1990 ◽  
Vol 156 (5) ◽  
pp. 615-619 ◽  
Author(s):  
John L. Waddington
Keyword(s):  
Positron Emission Tomography ◽  
Psychiatric Disorders ◽  
Dopamine Receptors ◽  
Metabolic Activity ◽  
New Technology ◽  
Emission Tomography ◽  
Brain Dopamine ◽  
The Past ◽  
Positron Emission ◽  
Schizophrenic Patients

Over the past several years there has emerged a family of highly sophisticated but technically complex procedures for the visualisation of a range of cerebral functions in living man (Andreasen, 1988). The images they produce are so beguiling not just because of their potential to give new insights into the pathophysiology and treatment of major psychiatric disorders, but because they convey information through a quite fundamental modality: people are only convinced by what they can see. However, initial applications of such new technology have appeared just as likely to generate new questions and contradictions as to provide answers to current issues. This is readily illustrated by recent studies on the imaging of brain dopamine receptors in schizophrenic patients by positron emission tomography (PET) (see Waddington, 1989a).

Neuroinflammation in schizophrenic patients: A positron emission tomography study with [11C]-(R)-PK11195

NeuroImage ◽  
2008 ◽  
Vol 41 ◽  
pp. T109 ◽  
Author(s):  
Janine Doorduin ◽  
E.F.J. deVries ◽  
A.T.M. Willemsen ◽  
R.A. Dierckx ◽  
H.C. Klein
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Positron Emission ◽  
Schizophrenic Patients
Sign in / Sign up

Export Citation Format

Share Document