scholarly journals From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones

IUBMB Life ◽  
2010 ◽  
Vol 62 (7) ◽  
pp. 492-496 ◽  
Author(s):  
Harvey Lodish ◽  
Johan Flygare ◽  
Song Chou
Keyword(s):  
Stem Cell ◽  
Red Cell ◽  
Cell Production ◽  
Multiple Levels

From Hematopoietic Stem Cell to Erythroblast: Regulation of Red Cell Production At Multiple Levels

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. SCI-1-SCI-1 ◽  
Author(s):  
Harvey F. Lodish
Keyword(s):  
Conflicts Of Interest ◽  
Inflammatory Diseases ◽  
Stress Hormones ◽  
Red Cells ◽  
Red Cell ◽  
Short Term ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Cell Production ◽  
Multiple Levels

Abstract SCI-1 Hematopoietic stem cells (HSC) undergo self-renewal and also generate all types of blood cells, including red cells, myeloid cells, and all immune system cells. Formation of red cells from HSC involves multiple cellular stages, including early erythroid-specific progenitors (burst-forming unit-erythroid [BFU-E]) that respond to several growth factors and an erythropoietin (Epo)-responsive progenitor, and the colony-forming unit-erythroid (CFU-E) that in 3 days generates ∼30 reticulocytes. In adult animals most CFU-E cells undergo apoptosis. A short-term need for red cells is met by increased Epo production by the kidney, which rescues increasing numbers of CFU-Es from apoptosis and increases red cell production over a few days. Chronic stress, such as in certain types of anemias and inflammatory diseases, leads to a marked increase in numbers of HSC and many types of progenitor cells. I will focus most of my talk on stress-triggered BFU-E proliferation and formation of CFU-Es, since our very recent work showed how glucocorticoids – an important class of stress hormones – as well as HIF-1α stimulate red cell production. Acting synergistically these allow ∼300 times more CFU-Es and erythroblasts to be formed from each BFU-E. More specifically, these molecules stimulate limited self-renewal of BFU-Es during cell division, thus maintaining progenitor immaturity and allowing over time increased numbers of CFU-E cells and thus mature red cells to be formed. This explains why certain corticosteroids are useful in treating some non-Epo responsive anemias, and I will present a molecular dissection of glucocorticoid and HIF-1α action on BFU-E progenitors that has led to the identification of genes critical for self-renewal and that suggest other possible avenues for treatment of chronic anemias. Disclosures: No relevant conflicts of interest to declare.

scholarly journals From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

Blood ◽  
2011 ◽  
Vol 118 (24) ◽  
pp. 6258-6268 ◽  
Author(s):  
Shilpa M. Hattangadi ◽  
Piu Wong ◽  
Lingbo Zhang ◽  
Johan Flygare ◽  
Harvey F. Lodish
Keyword(s):  
Stem Cell ◽  
Red Cell ◽  
Chromatin Modifications ◽  
Erythroid Progenitors ◽  
Chronic Anemia ◽  
Colony Forming Unit ◽  
Proliferation And Differentiation ◽  
Rapid Production ◽  
Multiple Levels ◽  
External Signals

Abstract This article reviews the regulation of production of RBCs at several levels. We focus on the regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids and other factors that occur during chronic anemia, inflammation, and other conditions of stress. We also highlight the rapid production of RBCs by the coordinated regulation of terminal proliferation and differentiation of committed erythroid colony-forming unit-erythroid progenitors by external signals, such as erythropoietin and adhesion to a fibronectin matrix. We discuss the complex intracellular networks of coordinated gene regulation by transcription factors, chromatin modifiers, and miRNAs that regulate the different stages of erythropoiesis.

Rate of red cell production in two nephrectomized patients

1968 ◽  
Vol 122 (3) ◽  
pp. 230-235 ◽  
Author(s):  
A. J. Erslev
Keyword(s):  
Red Cell ◽  
Cell Production

Automated stem cell production by bio-inspired control

2021 ◽  
Vol 33 ◽  
pp. 369-379
Author(s):  
László Monostori ◽  
Balázs Cs. Csáji ◽  
Péter Egri ◽  
Krisztián B. Kis ◽  
József Váncza ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Production

The red cell; production, metabolism, destruction: normal and abnormal.

JAMA ◽  
1963 ◽  
Vol 184 (5) ◽  
pp. 432
Author(s):  
Leon O. Jacobson
Keyword(s):  
Red Cell ◽  
Cell Production

A Test for Red Cell Production

1952 ◽  
Vol 7 (3) ◽  
pp. 129-143 ◽  
Author(s):  
Rex L. Huff ◽  
Cornelius A. Tobias ◽  
John H. Lawrence
Keyword(s):  
Red Cell ◽  
Cell Production

Anemias of Impaired Red Cell Production

2014 ◽  
pp. 1-1
Author(s):  
Ramadas Nayak ◽  
Sharada Rai
Keyword(s):  
Red Cell ◽  
Cell Production
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