[Triple-combined therapy of malignant cancer of the head and neck-maxillary cancer]

1969 ◽  
Vol 33 (4) ◽  
pp. 596-598
Author(s):  
Y Sato
Keyword(s):  
Head And Neck ◽  
Combined Therapy ◽  
Maxillary Cancer

Combined therapy for stage III-IV head and neck cancer: preliminary results.

1984 ◽  
Vol 2 (7) ◽  
pp. 804-810 ◽  
Author(s):  
S H Krasnow ◽  
M H Cohen ◽  
A Johnston-Early ◽  
M L Citron ◽  
B E Fossieck ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Response Rate ◽  
Combined Modality Therapy ◽  
Combined Therapy ◽  
Stage Iii ◽  
Combined Modality Treatment ◽  
Combined Modality ◽  
Rbc Deformability

As part of a combined modality treatment program using chemotherapy, surgery, and/or radiotherapy, 25 patients with previously untreated stage III or IV head and neck cancer received initial combination chemotherapy. Pathologically confirmed complete remission was noted in nine patients (36%). The overall objective major response rate (with all patients included in analysis) was 68%. The chemotherapy regimen included bleomycin, cisplatin, vinblastine, methotrexate, and 5-fluorouracil. A novel concept of drug scheduling was used, based on chemotherapy-induced improvement in RBC deformability. The underlying concept is that improved RBC deformability results in improved capillary blood flow and thereby, increased drug delivery to tumor cells. Treatment resulted in moderate hematologic and renal toxicity with no treatment-related deaths. This exceptionally high, pathologically confirmed complete response rate will hopefully provide a mechanism by which combined modality therapy can adequately be tested for its ability to prolong survival of patients with advanced head and neck cancer.

Solitary Neurogenous Sarcomas of the Head and Neck

1979 ◽  
Vol 87 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Capt Hugh O. DeFries ◽  
Michael B. Nolph ◽  
Alan D. Kornblut
Keyword(s):  
Head And Neck ◽  
Combined Therapy ◽  
Survival Rates ◽  
Surgical Excision ◽  
Satisfactory Treatment ◽  
Potential Patient

The clinical histories of three patients with neurogenous sarcomas involving the head and neck are detailed. The most satisfactory treatment suggested for such tumors involves combined therapy with chemotherapy, radiation, and radical surgical excision. By so doing, potential patient cure might be further increased and survival rates further improved.

Combined Therapy for Resectable Head and Neck Cancer: A Phase 3 Intergroup Study

1989 ◽  
Vol 115 (3) ◽  
pp. 364-368 ◽  
Author(s):  
D. E. Schuller ◽  
G. Laramore ◽  
M. Al-Sarraf ◽  
J. Jacobs ◽  
T. F. Pajak
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Combined Therapy ◽  
Phase 3

Uni- and multivariate analysis of eight indications for postoperative radiotherapy and their significance for local-regional cure in advanced head and neck cancer

1993 ◽  
Vol 107 (5) ◽  
pp. 437-440 ◽  
Author(s):  
L. A. Ravasz ◽  
G. J. Hordijk ◽  
P. J. Slootweg ◽  
F. Smit ◽  
I. V. D. Tweel
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Postoperative Radiotherapy ◽  
Combined Therapy ◽  
Primary Tumour ◽  
Undifferentiated Carcinoma ◽  
Advanced Head ◽  
Tumour Invasion ◽  
Invasive Tumour

Eighty consecutive patients with advanced head and neck cancer were treated with combined therapy of radical surgery and post-operative radiotherapy. Indications for post-operative radiotherapy were pathological staging of the primary tumour (pT3 or pT4), poorly differentiated or undifferentiated carcinoma (G3, G4), tumour thickness, tumour invasion in the surrounding tissues with slender tumour strands and solitary tumour cells, perineural spread, lymphangio-invasive tumour growth, multiple positive neck nodes or extranodal spread, and microscopical irradicality of the surgical margins. The contribution for prognosis of these indications for post-operative radiotherapy were retrospectively calculated in an univariate and multivariateanalysis. Of all investigated parameters, the mode of tumour invasion and lymphangio-invasive growth were independent prognostic factors. If these unfavourable prognostic signs are present, post-operative radiotherapy has to be intensified to at least curative doses of 66 Gy or more to the areas at risk.

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