Evaluation of a silica-containing bone graft substitute in a vertebral defect model

2009 ◽  
Vol 9999A ◽  
pp. NA-NA
Author(s):  
Hideo Kobayashi ◽  
A. Simon Turner ◽  
Howard B. Seim ◽  
Teruya Kawamoto ◽  
Thomas W. Bauer
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Defect Model

Porous Beta-Calcium Pyrophosphate as a Bone Graft Substitute in a Canine Bone Defect Model

2003 ◽  
Vol 240-242 ◽  
pp. 399-402 ◽  
Author(s):  
Jae Hyup Lee ◽  
D.H. Lee ◽  
Hyun Seung Ryu ◽  
Bong-Soon Chang ◽  
Kug Sun Hong ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Bone Graft Substitute ◽  
Calcium Pyrophosphate ◽  
Defect Model

Bovine-Derived Bone Protein as a Bone Graft Substitute in a Canine Segmental Defect Model

1997 ◽  
Vol 11 (7) ◽  
pp. 496-508 ◽  
Author(s):  
Marcus F. Sciadini ◽  
John M. Dawson ◽  
Kenneth D. Johnson
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Segmental Defect ◽  
Defect Model

IN VIVO EVALUATION OF A NEW β-TRICALCIUM PHOSPHATE BONE SUBSTITUTE IN A RABBIT FEMUR DEFECT MODEL

2015 ◽  
Vol 27 (03) ◽  
pp. 1550028 ◽  
Author(s):  
Kam-Kong Chan ◽  
Chia-Hsien Chen ◽  
Lien-Chen Wu ◽  
Yi-Jie Kuo ◽  
Chun-Jen Liao ◽  
...  
Keyword(s):  
Bone Graft ◽  
Tricalcium Phosphate ◽  
Bone Substitute ◽  
Zealand White Rabbit ◽  
Bone Substitutes ◽  
Bone Graft Substitute ◽  
Defect Model ◽  
In Vivo Evaluation ◽  
Rabbit Femur

Calcium phosphate ceramics, of a similar composition to that of mineral bone, and which possess the properties of bioactivity and osteoconductivity, have been widely used as substitutes for bone graft in orthopedic, plastic and craniofacial surgeries. A synthetic β-tricalcium phosphate, Osteocera™, a recently developed bone graft substitute, has been used in this study. To evaluate the affinity and efficacy of Osteocera™ as bone defect implant, we used a New Zealand white rabbit femur defect model to test the osteoconductivity of this new bone substitute. Alternative commercially available bone substitutes, Triosite® and ProOsteon500, were used as the control materials. These three bone substitutes show good biocompatibility, and no abnormal inflammation either infection was seen at the implantation sites. In the histological and histomorphometric images, newly formed bone grew into the peripheral pores in the bone substitutes. After six months implantation, the volume of bone formation was found to be 20.5 ± 5.2%, 29.8 ± 6.5% and 75.5 ± 4.9% of the potential total cavity offered by ProOsteon500, Triosite® and Osteocera™, respectively. The newly formed bone area within the femur defect section for Osteocera™ was significantly larger than ProOsteon500 and Triosite®. We concluded that Osteocera™ shows better bioresorbability, biocompatibility and osteoconductivity in the rabbit femur defect model.

scholarly journals Establishment and effects of allograft and synthetic bone graft substitute treatment of a critical size metaphyseal bone defect model in the sheep femur

Apmis ◽  
2019 ◽  
Vol 127 (2) ◽  
pp. 53-63 ◽  
Author(s):  
Werner Hettwer ◽  
Peter F. Horstmann ◽  
Sabine Bischoff ◽  
Daniel Güllmar ◽  
Jürgen R. Reichenbach ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Critical Size ◽  
Bone Graft Substitute ◽  
Defect Model ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Metaphyseal Bone

Coralline hydroxyapatite is a suitable bone graft substitute in an intra-articular goat defect model

2008 ◽  
Vol 90B (1) ◽  
pp. 116-122 ◽  
Author(s):  
S. Koëter ◽  
S. J. Tigchelaar ◽  
P. Farla ◽  
L. Driessen ◽  
A. van Kampen ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Defect Model ◽  
Coralline Hydroxyapatite

Evaluation of bovine-derived bone protein with a natural coral carrier as a bone-graft substitute in a canine segmental defect model

1997 ◽  
Vol 15 (6) ◽  
pp. 844-857 ◽  
Author(s):  
Marcus F. Sciadini ◽  
John M. Dawson ◽  
Kenneth D. Johnson ◽  
M. F. Sciadini
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Segmental Defect ◽  
Defect Model ◽  
Natural Coral

A resorbable porous ceramic composite bone graft substitute in a rabbit metaphyseal defect model

2003 ◽  
Vol 21 (4) ◽  
pp. 655-661 ◽  
Author(s):  
W. R. Walsh ◽  
P. J. Chapman-Sheath ◽  
S. Cain ◽  
J. Debes ◽  
W. J. M. Bruce ◽  
...  
Keyword(s):  
Bone Graft ◽  
Ceramic Composite ◽  
Porous Ceramic ◽  
Bone Graft Substitute ◽  
Defect Model ◽  
Porous Ceramic Composite ◽  
Composite Bone

Nanoparticulate Hydroxyapatite Enhances the Bioactivity of a Resorbable Bone Graft

2002 ◽  
Vol 735 ◽  
Author(s):  
Stephen A. Doherty ◽  
David D. Hile ◽  
Donald L. Wise ◽  
Jackie Y. Ying ◽  
Stephen T. Sonis ◽  
...  
Keyword(s):  
Bone Graft ◽  
Histological Analysis ◽  
Mechanical Stability ◽  
Unsaturated Polyester ◽  
Biological Response ◽  
Bone Graft Substitute ◽  
Calvarial Defect ◽  
Defect Model ◽  
Rat Calvarial Defect ◽  
Poly Propylene

ABSTRACTA nanoparticulate-hydroxyapatite filler augmented osteointegration within a resorbable polymer based bone graft substitute designed for orthopaedic and periodontal applications. The unsaturated polyester poly(propylene glycol-co-fumaric acid) (PPF), was used to prepare the bone graft substitute. The nanoparticulate-hydroxyapatite filler was examined in terms of biocompatibility, bony ingrowth and mechanical stability in a rat calvarial defect model. The nano-hydroxyapatite fillerwas compared against a commercially available micrometer-sized hydroxyapatite(HA) filler. Histological analysis indicated that remodeling of the newly formed bone was more advanced in the defect filled with the nano-hydroxyapatite augmented PPF. Mechanical evaluation showed a more rapid increase in stiffness of the nano-hydroxyapatite PPF. Implants of the nano-HA augmented PPF showed more advanced bone formation and recovery of mechanical properties, suggesting an improved biological response to the nano-sized particles.

Sign in / Sign up

Export Citation Format

Share Document