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Published By Trans Tech Publications

1662-9795
Updated Monday, 18 October 2021

2021 ◽  
Vol 901 ◽  
pp. 129-136
Author(s):  
Pornphan Leelaudomlipi ◽  
Somkamol Manchun ◽  
Piyaporn Supakdamrongkul ◽  
Parapat Sobharaksha

The objective of this research is to evaluate the antimicrobial activity of Nanostructured Lipid Carriers (NLCs) loading violacein extract. The extract was tested for the antimicrobial activities against 3 strains of pathogenic bacteria; namely Cutibacterium acnes ATCC 6919, Staphylococcus aureus ATCC 6538 and Staphylococcus epidermidis ATCC 12228 by agar well diffusion assay. The result indicated that the violacein extract from Chromobacterium violaceum ATCC 12472 has strongest antibacterial effect against C. acnes, S. aureus and S. epidermidis with MIC values in range of 0.0146-0.4688 mg/mL with the lowest MBC value of 0.0146 mg/mL against C. acnes. Violacein extract loaded Nanostructured Lipid Carriers (NLCs) for anti-acne products were prepared by using melt-emulsification technique. The studied factors are the ratio of liquid lipid and solid lipid (LL:SL), surfactant concentration and sonication time. The Ratio of Oleic acid and Compritol® 888 ATO (3:1) with Tween 20 (1.5% w/w) and sonication time of 10 minute (F8 formulation) are an optimizing condition for NLC-Base. The resulted formulations showed the NLC-Base had average particle size of 213.7±2.42 nm with a polydispersity index of 0.239±0.003 and Zeta potential of -26.6±0.45 mV. After that, violacein extract (2% w/w) was loaded into the NLCs (VIO-NLCs). Antibacterial activity of VIO-NLCs 2 % was determined by using agar dilution. The result showed that VIO-NLCs 2 % can inhibit the growth of C. acnes for 60 days during storage. Furthermore, VIO-NLCs 2 % can also act as S. aureus and S. epidermidis inhibitor within 30 days shelf life.


2021 ◽  
Vol 901 ◽  
pp. 35-39
Author(s):  
Sukannika Tubtimsri ◽  
Yotsanan Weerapol

The amorphous solid dispersions (ASDs) containing amino methacrylate copolymer and surface-active agents were prepared to improve the nifedipine (NDP) dissolution. The different types of surface-active agent i.e., polysorbates 80, sodium lauryl sulfate (SLS) and polyethylene glycol (PEG) 400 were used. In order to evaluate the ASDs formulation,powder X-ray diffractometry and thermal analysis to characterize NDP crystallinity in ASDs and the dissolution study of NDP have been performed to compare the dissolution profiles. The ASDs were kept for 6 months to investigate the stability. In the X-ray diffraction pattern, no peak was observed in all samples of ASDs. No peak was found in sample of all ASDs from the thermograms. These results suggest that the drug may be molecularly dispersed in matrix of amino methacrylate copolymer. The drug dissolution at 120 min, from ASDs without surface-active agent and NDP powder were 58.31% and 17.95%, respectively. The dissolved NDP from ASDs composed of SLS, polysorbate 80 and PEG400 were 96.25%, 88.86% and 75.32%, respectively. These results may occur due to the reduction of surface tension, the addition of the low amount of high efficiency of surface-active agent e.g., SLS (compared with PEG400 and polysorbate 80) provided the higher NDP dissolution. The content analysis of NDP in selected ASDs was studied at the end of 3 and 6 months, the NDP content remained unchanged after storage.


2021 ◽  
Vol 901 ◽  
pp. 22-27
Author(s):  
Kanokporn Burapapadh ◽  
Narumon Changsan ◽  
Chutima Sinsuebpol ◽  
Phennapha Saokham

Dictyophora indusiata known as bamboo mushroom is an edible mushroom in Genus Dictyophora, Family Phallaceae that could produce highly viscous mucilage encased in the peridium. The viscous mucilage is clear-colorless hydrocolloid with high viscosity and high adhesive nature which made it possible to be developed into pharmaceutical excipients. This research work aimed at the application of the mucilage as a tablet binder. The mucilage was prepared as redispersible powder by lyphilization before used. The dried mucilage could be effectively used as a binder in paracetamol tablet formulations both as dry and wet binder. Increasing of the dried mucilage amount caused the stronger tablet with higher disintegration time. The optimum concentrations of the dried mucilage in tablet formulations were 2.0% w/w as dry binder and 1.0% w/w as wet binder. The obtained tablets revealed low friability and fast disintegration time. The drug dissolution was conformable to USP37 standard and comparable to that of commercial product. Accordingly, the Dictyophora indusiata mucilage could be functionally used as a tablet binder


2021 ◽  
Vol 901 ◽  
pp. 28-34
Author(s):  
Nattawat Nattapulwat ◽  
Penpun Wetwitayaklung ◽  
Burin T. Sriwong

The objective of this research aimed to 1. formulate chewable toothpaste tablets containing mangosteen rind extract, 2. compare the suitable filler between lactose anhydrous and mannitol that adsorbs mangosteen rind extract by flowability and appearance indicators, 3. study the effect of type and amounts of foaming agents on stability of foam that leads to appropriate formulation, and 4. study market feasibility of chewable toothpaste tablets containing mangosteen rind extract. Survey method and self-administered questionnaire was used for data collection both before and after formulation in capital district of Nakhon Pathom. Thirty participants were selected and categorized into five groups which are tourists, dental patients, pharmacy students at Silpakorn University, office workers and dentists. After data collection is done, it was analyzed by using descriptive statistics. Results showed that mannitol is an appropriate adsorbent. It showed proper color and appearance as well as good flowability of extract. Cocamidopropyl betaine was selected as foaming agent. According to the survey, participants are interested in product. In addition, some dental specialists suggested to add fluoride. Overall, this product is interested and accepted among participants. Therefore, consumers are likely to buy chewable toothpaste tablet containing mangosteen rind extract.


2021 ◽  
Vol 901 ◽  
pp. 48-54
Author(s):  
Nattaporn Amornopparattanakul ◽  
Neti Waranuch ◽  
Supaporn Lamlertthon ◽  
Wudtichai Wisuitiprot ◽  
Kornkanok Ingkaninan

“Mild” oral care products are needed by some groups of people, such as radiotherapy patients. This study developed oral cleansing products containing green tea (Camelia sinensis (L.) Kuntze) extracts with antibacterial activities and Centella asiatica (L.) Urb. extracts with a wound healing activity. We found that 3.13 mg/ml of green tea extract inhibited both Streptococcus mutans and Candida albicans, which can cause dental caries and oral candidiasis, respectively. Also, a 16 μg/ml C. asiatica extract promoted fibroblast migration in a wound healing study. The products were developed in 2 dosage forms, i.e. a solution and an impregnated gauze, which were isotonic, alcohol and volatile oil free formulations to prevent irritation and burning sensations. The products showed acceptable physical stability after testing under stressed conditions with post-test retention of antimicrobial activity.


2021 ◽  
Vol 901 ◽  
pp. 219-225
Author(s):  
Elena V. Torskaya ◽  
Alexey M. Mezrin

Mechanical properties of surface layers of aluminum alloys before and after friction tests are studied by nanoindentation. The influence of the composition of the alloys on these properties is analyzed. It is obtained that as a result of wear and tear, relatively compliant layer is formed on the surface of one of the alloys. Another sample demonstrates relatively rigid film at the surface of the friction path. Conclusions about different mechanisms of the wear and tear of alloys are made based on the analysis.


2021 ◽  
Vol 901 ◽  
pp. 98-103
Author(s):  
Sunee Channarong ◽  
Parapat Sobharaksha ◽  
Chanchai Sardseangjun ◽  
Panipak Vasvid

Abstract The aim of this study was to fabricate curcumin-loaded polymeric mixed micelle which was a new nanocarrier of therpeutic agent for skin uses. Curcumin was extracted from dried turmeric rhizomes using ethanol and recrystallized. The purity of curcumin was 79±3.6 %w/w. Six curcumin-loaded polymeric micelles (PM1-PM6) were prepared by simple dissolution method using poloxamer 407 (5% and 10%) as a main core structure. PEG-40 hydrogenated castor oil (PEG-40HCO) was incorporated at two percentages (2.5% and 5.0%) to study the effect on the nanoparticle characteristics. The average particle sizes of PM1-PM6 were in the range of 33.3±6.6 nm to 171.3±52.8 nm. The entrapment efficiency and the loading capacity of curcumin were in the range of 47.45%-77.35% and 0.048%w/w-0.078%w/w, respectively. When PEG-40HCO was incorporated in to the polymeric micelles, the particle size decreased and the entrapment efficiency increased. Thus, PM4 and PM5 were selected for further study. Moisturizing antioxidant creams containing 0.005%w/w of curcumin loaded in PM4, PM5 and curcumin simply dissolved in propylene glycol (PG) were formulated. The resulted formulations showed good spreadability and good characteristics. After being subjected to accelerated test, all of the formulations remained with characteristic color, pH and showed no phase separation. The stability data showed that the moisturizing antioxidant creams were stable for the whole 3 months after storage at accelerated temperature (45°C/75%RH). The study demonstrated that polymeric mixed micelle spontaneously encapsulated a poorly water-soluble curcumin and increased the solubility up to 250 folds. The developed moisturizing cream containing 0.005%w/w of curcumin resulted a greenish-yellow color preparation. It had tolerable physicochemical properties based on curcumin content, pH and viscosity under the harsh condition. The cream also had satisfactory antioxidant activity, which can be regarded as an effective and acceptable therapeutic or skincare products for topical uses.


2021 ◽  
Vol 901 ◽  
pp. 111-116
Author(s):  
Nuttawut Supachawaroj ◽  
Sucharat Limsitthichaikoon

Dry socket disease, a pocket wound caused by the tooth extraction that resulted in severe acute pain which requires a topical analgesic with rapidly pain reduction and suppress the pain until the wound healed. This study aimed to investigate factors affecting gelation temperature and gelation time of lidocaine hydrochloride (LH)-loaded polyelectrolyte complex (PEC) thermosensitivity gel for treating dry socket wound. The first factor was investigated the effects of the ratio of three different types of polymers as chitosan (CS), hyaluronic acid (HA) and poloxamer407 (P407) on the phase transition caused by temperature. The second factor was examined the effects of gel preparation methods. The results showed that increasing concentration of the cationic polymer as CS induced the separation of the solution to gel (sol-to-gel) system due to the charge of CS and the charge of PEC. The ratio of HA:P407 affected the gel forming which high concentration of P407 reduced the gelation temperature while low concentration of HA disturbed the sol-to-gel state causing coagulation. The viscosity, spreadability, and swelling were significantly increased due to the concomitant increased in each polymer, HA and P407. The particle of the formulation observed under microscope was found to be less than 1 µm. Phase inversion from sol-to-gel was found after a min at 23°C. Since gelation temperature of the purposed formula is supposed to form gel below 37°C within a short period of injection. The results of the study indicate the suitable sol-to-gel forming in the appropriate temperature and time which should be used for further investigation in the efficacy and safety.


2021 ◽  
Vol 901 ◽  
pp. 67-72
Author(s):  
Chein Yhirayha ◽  
Sakchai Wittaya-Areekul ◽  
Tasana Pitaksuteepong

Morus alba stem extract possesses several biological activities. However, skin delivery of the extract is limited by the stratum corneum. In this study, lamellar lyotropic liquid crystal (LLC) was investigated for the potential application in the skin delivery of M. alba stem extract. The four formulations were developed and incorporated with M. alba stem extract at 3% w/w. These formulations were stored at room temperature in light-protected containers for 3 months. The optical pattern under polarized light microscope, viscosity and remaining of the extract were determined. The skin penetration enhancing property of the formulations was investigated using excised porcine ear skin model. The results showed that all formulations remained stable after 3-month storage. The two formulations exhibiting good penetration enhancing properties were F3 consisting of PEG-7 glyceryl cocoate/n-Dodecane/Water/extract (55.29/19.40/22.31/3.00 %w/w) and F4 consisting of mixed Surfactant/n-Dodecane/Water/extract (48.50/4.85/43.65/3.00 %w/w). The mixed surfactant composed of PEG-7 glyceryl cocoate/PEG-40 hydrogenated castor oil/Glyceryl oleate (40/33.24/26.76 %w/w). It can be concluded that the lamellar LLC formulations developed in this study can be used as a carrier for delivering of M. alba stem extract. The components of the formulations which play important roles are the oil and the surfactant.


2021 ◽  
Vol 901 ◽  
pp. 40-47
Author(s):  
Chanikanda Tessiri ◽  
Sunee Channarong ◽  
Paveena Wongtrakul

Mangiferin, a polyphenol of C-glycosylxanthone, exhibits various bioactivities with poor aqueous solubility. It is known as a potent antioxidant, which leads to remarkable UV protection and anti-aging properties. Mangiferin can be found in many plant species, among which the mango leaf is one of the primary sources. From our study, the extraction yield of mangifein obtained from the leaves of Mangifera indica L. variety Nam Doc Mai was 3.17% with 95.02% ± 0.064 purity (HPTLC analysis). The solubility of mangiferin in the studied pure solvents arranging in descending order were ethoxydiglycol, dimethyl isosorbide, polyethylene glycol 400, polyethylene glycol 600, propylene glycol, dipropylene glycol, glycerin, isopentyldiol, methanol, ethanol and water, whereas the addition of the solvent in water could increase the aqueous solubility of mangiferin. In several cases, the solubility was apparently higher than that dissolved in its pure solvent state. The log-linear solubility model for the cosolvent system was used to calculate the volume fractions of the selected solvents needed to solubilize mangiferin content at the twenty times of the IC50 against DPPH radicals. In conclusion, the developed aqueous formulation contained 0.5% w/v of mangiferin and 20% w/v of polyethylene glycol 600 or dipropylene glycol as a solubilizer in water.


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