Porous Beta-Calcium Pyrophosphate as a Bone Graft Substitute in a Canine Bone Defect Model

A novel antibacterial bone graft substitute was developed to repair bone defects and to inhibit related infections simultaneously. This bone composite was prepared by introducing vancomycin (VCM) to nanohydroxyapatite/collagen/calcium sulphate hemihydrate (nHAC/CSH). XRD, SEM, and CCK-8 tests were used to characterize the structure and morphology and to investigate the adhesion and proliferation of murine osteoblastic MC3T3-E1 cell on VCM/nHAC/CSH composite. The effectiveness in restoring infectious bone defects was evaluatedin vivousing a rabbit model of chronic osteomyelitis. Ourin vivoresults implied that the VCM/nHAC/CSH composite performed well both in antibacterial ability and in bone regeneration. This novel bone graft substitute should be very promising for the treatment of bone defect-related infection in orthopedic surgeries.

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IN VIVO EVALUATION OF A NEW β-TRICALCIUM PHOSPHATE BONE SUBSTITUTE IN A RABBIT FEMUR DEFECT MODEL

Biomedical Engineering Applications Basis and Communications ◽

10.4015/s1016237215500283 ◽

2015 ◽

Vol 27 (03) ◽

pp. 1550028 ◽

Cited By ~ 1

Author(s):

Kam-Kong Chan ◽

Chia-Hsien Chen ◽

Lien-Chen Wu ◽

Yi-Jie Kuo ◽

Chun-Jen Liao ◽

...

Keyword(s):

Bone Graft ◽

Tricalcium Phosphate ◽

Bone Substitute ◽

Zealand White Rabbit ◽

Bone Substitutes ◽

Bone Graft Substitute ◽

Defect Model ◽

In Vivo Evaluation ◽

Rabbit Femur

Calcium phosphate ceramics, of a similar composition to that of mineral bone, and which possess the properties of bioactivity and osteoconductivity, have been widely used as substitutes for bone graft in orthopedic, plastic and craniofacial surgeries. A synthetic β-tricalcium phosphate, Osteocera™, a recently developed bone graft substitute, has been used in this study. To evaluate the affinity and efficacy of Osteocera™ as bone defect implant, we used a New Zealand white rabbit femur defect model to test the osteoconductivity of this new bone substitute. Alternative commercially available bone substitutes, Triosite® and ProOsteon500, were used as the control materials. These three bone substitutes show good biocompatibility, and no abnormal inflammation either infection was seen at the implantation sites. In the histological and histomorphometric images, newly formed bone grew into the peripheral pores in the bone substitutes. After six months implantation, the volume of bone formation was found to be 20.5 ± 5.2%, 29.8 ± 6.5% and 75.5 ± 4.9% of the potential total cavity offered by ProOsteon500, Triosite® and Osteocera™, respectively. The newly formed bone area within the femur defect section for Osteocera™ was significantly larger than ProOsteon500 and Triosite®. We concluded that Osteocera™ shows better bioresorbability, biocompatibility and osteoconductivity in the rabbit femur defect model.

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Evaluation of porous β-calcium pyrophosphate as bioresorbable bone graft substitute material

Materials Research Innovations ◽

10.1179/1433075x14y.0000000215 ◽

2014 ◽

Vol 19 (2) ◽

pp. 86-90 ◽

Cited By ~ 2

Author(s):

K.-S. Lee ◽

H.-S. Han ◽

Y.-C. Kim ◽

J. H. Lo Han ◽

H.- Seung R. ◽

...

Keyword(s):

Bone Graft ◽

Bone Graft Substitute ◽

Calcium Pyrophosphate ◽

Substitute Material

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The Annals of Biomedical Engineering on Critical Size Bone Defect: A Review

Malaysian Journal of Science Health & Technology ◽

10.33102/mjosht.v6i.118 ◽

2021 ◽

Author(s):

Azimah Ahmad Zainol Hady ◽

Liyana Azmi ◽

Amira Raudhah Abdullah

Keyword(s):

Bone Graft ◽

Fracture Healing ◽

Bone Defect ◽

Critical Size ◽

Healing Process ◽

Bone Defects ◽

Bone Graft Substitute ◽

Physiological Process ◽

Mechanical Stabilization ◽

Bone Injury

Bone can heal on its own through the process known as bone remodelling. Nonetheless, a critical size bone defect will hinder the natural bone-healing process and may not allow for complete fracture healing. These requires surgical intervention by employing the use of bone tissue implants and in need of realignment and fixation for proper fracture healing. Traditional knowledge of bone injury and fracture healing must be comprehended thoroughly for a proper invention of bioengineered material or devices that could enhance the physiological process. Heretofore, engineered materials used to address critical size bone defects have encountered various challenges and improvement be it in bone grafting or choices of mechanical stabilization devices. To date, researchers have been mainly focussing on the alternative material for bone graft substitute albeit the selection of fixators to establish mechanical stabilization are as important. This review highlighted the challenges, improvement and advancement in mechanical stabilization devices and bone graft substitute with respect to the physiological process of bone fracture healing. Identifying these challenges would help assist the researcher in an expedition toward the recovery and restoration of critical size bone defects.

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