scholarly journals Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures

2012 ◽  
Vol 27 (3) ◽  
pp. 672-678 ◽  
Author(s):  
Eve Donnelly ◽  
Dennis S Meredith ◽  
Joseph T Nguyen ◽  
Brian P Gladnick ◽  
Brian J Rebolledo ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Postmenopausal Women ◽  
Compositional Heterogeneity ◽  
Bisphosphonate Treatment ◽  
Subtrochanteric Fractures

scholarly journals Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance

2017 ◽  
Vol 114 (33) ◽  
pp. 8722-8727 ◽  
Author(s):  
Ashley A. Lloyd ◽  
Bernd Gludovatz ◽  
Christoph Riedel ◽  
Emma A. Luengo ◽  
Rehan Saiyed ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Postmenopausal Women ◽  
Osteoporotic Fractures ◽  
Fracture Morphology ◽  
Fracture Repair ◽  
Initiation Toughness ◽  
Bisphosphonate Treatment ◽  
Toughening Mechanisms ◽  
Bone Biopsies

Bisphosphonates are the most widely prescribed pharmacologic treatment for osteoporosis and reduce fracture risk in postmenopausal women by up to 50%. However, in the past decade these drugs have been associated with atypical femoral fractures (AFFs), rare fractures with a transverse, brittle morphology. The unusual fracture morphology suggests that bisphosphonate treatment may impair toughening mechanisms in cortical bone. The objective of this study was to compare the compositional and mechanical properties of bone biopsies from bisphosphonate-treated patients with AFFs to those from patients with typical osteoporotic fractures with and without bisphosphonate treatment. Biopsies of proximal femoral cortical bone adjacent to the fracture site were obtained from postmenopausal women during fracture repair surgery (fracture groups, n = 33) or total hip arthroplasty (nonfracture groups, n = 17). Patients were allocated to five groups based on fracture morphology and history of bisphosphonate treatment [+BIS Atypical: n = 12, BIS duration: 8.2 (3.0) y; +BIS Typical: n = 10, 7.7 (5.0) y; +BIS Nonfx: n = 5, 6.4 (3.5) y; −BIS Typical: n = 11; −BIS Nonfx: n = 12]. Vibrational spectroscopy and nanoindentation showed that tissue from bisphosphonate-treated women with atypical fractures was harder and more mineralized than that from bisphosphonate-treated women with typical osteoporotic fractures. In addition, fracture mechanics measurements showed that tissue from patients treated with bisphosphonates had deficits in fracture toughness, with lower crack-initiation toughness and less crack deflection at osteonal boundaries than that of bisphosphonate-naïve patients. Together, these results suggest a deficit in intrinsic and extrinsic toughening mechanisms, which contribute to AFFs in patients treated with long-term bisphosphonates.

Micro-morphological properties of osteons reveal changes in cortical bone stability during aging, osteoporosis and bisphosphonate treatment in women

2013 ◽  
Author(s):  
Andreas Bernhard ◽  
Petar Milovanovic ◽  
Michael Hahn ◽  
Danijela Djonic ◽  
Matthias Krause ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Morphological Properties ◽  
Bisphosphonate Treatment

A population-based comparison of cortical bone thickness and porosity in pre- and postmenopausal women by HR-PQCT

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S372-S373
Author(s):  
K.K. Nishiyama ◽  
H.M. Macdonald ◽  
H.R. Buie ◽  
D.A. Hanley⁎ ◽  
S.K. Boyd
Keyword(s):  
Cortical Bone ◽  
Postmenopausal Women ◽  
Population Based ◽  
Bone Thickness ◽  
Cortical Bone Thickness

Comparison of cortical bone thickness, porosity, and density in pre- and postmenopausal women measured by HR-pQCT at the distal radius and tibia

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S96-S97
Author(s):  
K.K. Nishiyama ◽  
H.M. Macdonald ◽  
H.R. Buie ◽  
D.A. Hanley ◽  
S.K. Boyd
Keyword(s):  
Cortical Bone ◽  
Postmenopausal Women ◽  
Distal Radius ◽  
Bone Thickness ◽  
Cortical Bone Thickness

The measurement of mandibular cortical bone height in osteoporotic vs. non-osteoporotic postmenopausal women

1995 ◽  
Vol 15 (3) ◽  
pp. 124-128 ◽  
Author(s):  
E. Lea Watson ◽  
R.V. Katz ◽  
R. Adelezzi ◽  
Helen C. Gift ◽  
S.M. Dunn
Keyword(s):  
Cortical Bone ◽  
Postmenopausal Women ◽  
Bone Height

scholarly journals Effects of Bisphosphonate Treatment on Circulating Osteogenic Endothelial Progenitor Cells in Postmenopausal Women

2013 ◽  
Vol 88 (1) ◽  
pp. 46-55 ◽  
Author(s):  
Pilar Peris ◽  
Elizabeth J. Atkinson ◽  
Mario Gössl ◽  
Trevor L. Kane ◽  
Louise K. McCready ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Bisphosphonate Treatment ◽  
Endothelial Progenitor

Comparative effects of denosumab or bisphosphonate treatment on bone mineral density and calcium metabolism in postmenopausal women

Maturitas ◽  
2017 ◽  
Vol 100 ◽  
pp. 156
Author(s):  
Evaggelia Karopoulou ◽  
Areti Augoulea ◽  
Ioannis Triantafyllopoulos ◽  
Demetrios Rizos ◽  
Eleni Armeni ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Calcium Metabolism ◽  
Bisphosphonate Treatment ◽  
Mineral Density

scholarly journals Glucocorticoid Excess Affects Cortical Bone Geometry in Premenopausal, but not Postmenopausal, Women

2008 ◽  
Vol 82 (3) ◽  
pp. 182-190 ◽  
Author(s):  
Hiroshi Kaji ◽  
Mika Yamauchi ◽  
Kazuo Chihara ◽  
Toshitsugu Sugimoto
Keyword(s):  
Cortical Bone ◽  
Postmenopausal Women ◽  
Bone Geometry ◽  
Cortical Bone Geometry
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