Viruses and cytokines: Evidence for multiple roles in pancreatic beta cell destruction in type 1 insulin-dependent diabetes mellitus

1989 ◽  
Vol 40 (1) ◽  
pp. 57-66 ◽  
Author(s):  
Iain L. Campbell ◽  
Leonard C. Harrison
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Multiple Roles ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Beta Cell Destruction ◽  
Insulin Dependent

Residual Pancreatic Beta-Cell Function in Insulin-Dependent Diabetes Mellitus

1987 ◽  
Vol 29 (3) ◽  
pp. 408-413
Author(s):  
Shin Amemiya ◽  
Kohsuke Higashida ◽  
Masatoshi Fujimoto ◽  
Kohtaro Asayama ◽  
Kazuyoshi Ichimura ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
Pancreatic Beta Cell Function

scholarly journals Cell-based therapy for insulin-dependent diabetes mellitus

1998 ◽  
pp. 129-133 ◽  
Author(s):  
S Efrat
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Cell Lines ◽  
Pancreatic Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Reversible Transformation ◽  
Cell Based Therapy ◽  
Insulin Dependent

Insulin-secreting pancreatic beta-cell lines represent a promising approach for treatment of insulin-dependent diabetes mellitus. Such cell lines can provide an abundant and reproducible source of beta-cell material for transplantation. A number of highly differentiated beta-cell lines have been developed using transgenic mice. These cells produce insulin amounts comparable to normal pancreatic islets and release it in response to physiological insulin secretagogues. Our laboratory has employed a reversible transformation approach to tightly regulate cell replication in these beta-cell lines, both in culture and in vivo. Beta-cell lines can be modulated by gene transfer to improve their function and survival. We have utilized adenovirus genes, which downregulate antigen presentation and increase cell resistance to cytokines, to facilitate transplantation of mouse beta cells across allogeneic barriers. These approaches could be applied to the development of human beta-cell lines by genetic engineering of isolated human islets.

Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus

Diabetes ◽  
1986 ◽  
Vol 35 (2) ◽  
pp. 139-142 ◽  
Author(s):  
S. Srikanta ◽  
A. T. Ricker ◽  
D. K. McCulloch ◽  
J. S. Soeldner ◽  
G. S. Eisenbarth ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Insulin Dependent
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