Analgesic effects of microRNA‐129‐5p against bone cancer pain through the EphB1/EphrinB2 signaling pathway in mice

2018 ◽  
Vol 120 (3) ◽  
pp. 2876-2885 ◽  
Author(s):  
Shao‐Nan Yu ◽  
Gui‐Feng Liu ◽  
Long‐Yun Li ◽  
Guo‐Qing Zhao ◽  
Lin Liu ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Signaling Pathway ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Analgesic Effects

Protease-Activated Receptor 2 Antagonist Potentiates Analgesic Effects of Systemic Morphine in a Rat Model of Bone Cancer Pain

2015 ◽  
Vol 40 (2) ◽  
pp. 158-165 ◽  
Author(s):  
Yanju Bao ◽  
Wei Hou ◽  
Liping Yang ◽  
Xiangying Kong ◽  
Maobo Du ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Rat Model ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Analgesic Effects ◽  
Protease Activated Receptor 2

scholarly journals Levo-Tetrahydropalmatine Attenuates Bone Cancer Pain by Inhibiting Microglial Cells Activation

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Mao-yin Zhang ◽  
Yue-peng Liu ◽  
Lian-yi Zhang ◽  
Dong-mei Yue ◽  
Dun-yi Qi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Mechanical Allodynia ◽  
Thermal Hyperalgesia ◽  
Bone Cancer ◽  
Microglial Cells ◽  
Bone Cancer Pain ◽  
Enzyme Linked Immunosorbent Assay ◽  
Analgesic Effects ◽  
Before And After

Objective. The present study is to investigate the analgesic roles of L-THP in rats with bone cancer pain caused by tumor cell implantation (TCI).Methods. Thermal hyperalgesia and mechanical allodynia were measured at different time points before and after operation. L-THP (20, 40, and 60 mg/kg) were administrated intragastrically at early phase of postoperation (before pain appearance) and later phase of postoperation (after pain appearance), respectively. The concentrations of TNF-α, IL-1β, and IL-18 in spinal cord were measured by enzyme-linked immunosorbent assay. Western blot was used to test the activation of astrocytes and microglial cells in spinal cord after TCI treatment.Results. TCI treatment induced significant thermal hyperalgesia and mechanical allodynia. Administration of L-THP at high doses significantly prevented and/or reversed bone cancer-related pain behaviors. Besides, TCI-induced activation of microglial cells and the increased levels of TNF-αand IL-18 were inhibited by L-THP administration. However, L-THP failed to affect TCI-induced astrocytes activation and IL-1βincrease.Conclusion. This study suggests the possible clinical utility of L-THP in the treatment of bone cancer pain. The analgesic effects of L-THP on bone cancer pain maybe underlying the inhibition of microglial cells activation and proinflammatory cytokines increase.

Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice

Neuropeptides ◽  
2018 ◽  
Vol 68 ◽  
pp. 36-42 ◽  
Author(s):  
Ming-Ming Han ◽  
Cheng-Wei Yang ◽  
Chi-Wai Cheung ◽  
Juan Li
Keyword(s):  
Cancer Pain ◽  
Signaling Pathway ◽  
Bone Cancer ◽  
Erk Signaling ◽  
Bone Cancer Pain ◽  
Endothelin A

Analgesic effects of neurotensin agonists in a rat bone cancer pain model

2016 ◽  
Author(s):  
Louis Dore-Savard ◽  
Pascal Tetreault ◽  
Melisange Roux ◽  
Marylie Martel ◽  
Myriam Lemire ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Weight Bearing ◽  
Bone Cancer ◽  
Opioid Analgesics ◽  
Bone Cancer Pain ◽  
Intractable Pain ◽  
Analgesic Effects ◽  
Selective Agonist ◽  
Neurotensin Receptors ◽  
Pain Models

Bone metastases are a source of intractable pain, resistant to conventional opioid and non-opioid analgesics. The neurotensin system represents a potential pathway toward bone cancer pain (BCP) relieve via the inhibition of its receptors NTS1 and NTS2. Capitalizing on our recent results using neurotensin analogs in inflammatory and neuropathic pain models, we here show, for the first time, a potential role for neurotensin receptors agonists in the treatment of BCP. The novel non-selective agonist JMV-2009 (300 μg/kg) reversed mechanical allodynia in our rodent BCP model at both early and late stages of the disease. The NTS2-selective agonist JMV-431 (90 μg/kg), in addition to anti-allodynia, also had an effect on weight bearing deficits. In parallel, we tested proven analgesics from several classes to put the effect of neurotensin analogs in perspective and found that morphine (3 mg/kg), tramadol (15 mg/kg) and amitriptyline (10 mg/kg) had mild effects on BCP while the cannabinoid nabilone (1 mg/kg) significantly reversed both allodynia and weight bearing deficits. Taken together, our results affirm the potential of the modulation of the neurotensin system for the development of new analgesics for the treatment of bone cancer pain.

Activation of spinal TDAG8 and its downstream PKA signaling pathway contribute to bone cancer pain in rats

2012 ◽  
Vol 36 (1) ◽  
pp. 2107-2117 ◽  
Author(s):  
Li-Hua Hang ◽  
Jian-Ping Yang ◽  
Wei Yin ◽  
Li-Na Wang ◽  
Feng Guo ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Signaling Pathway ◽  
Bone Cancer ◽  
Bone Cancer Pain

Analgesic effects of a soy-containing diet in three murine bone cancer pain models

2004 ◽  
Vol 5 (2) ◽  
pp. 104-110 ◽  
Author(s):  
Chengshui Zhao ◽  
Paul W Wacnik ◽  
Jill M Tall ◽  
David C Johns ◽  
George L Wilcox ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Analgesic Effects ◽  
Pain Models

scholarly journals Topical treatment with Xiaozheng Zhitong Paste alleviates bone cancer pain by inhibiting proteinase-activated receptor 2 signaling pathway

2015 ◽  
Vol 34 (3) ◽  
pp. 1449-1459 ◽  
Author(s):  
YANJU BAO ◽  
GAIMEI WANG ◽  
YEBO GAO ◽  
MAOBO DU ◽  
LIPING YANG ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Signaling Pathway ◽  
Topical Treatment ◽  
Bone Cancer ◽  
Bone Cancer Pain

Involvement of the spinal NMDA receptor/PKCγ signaling pathway in the development of bone cancer pain

2010 ◽  
Vol 1335 ◽  
pp. 83-90 ◽  
Author(s):  
Gu Xiaoping ◽  
Zhou XiaoFang ◽  
Zheng YaGuo ◽  
Zhang Juan ◽  
Wang JunHua ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Cancer Pain ◽  
Signaling Pathway ◽  
Bone Cancer ◽  
Bone Cancer Pain
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