Intracellular density is a novel indicator of differentiation stages of murine osteoblast lineage cells

Decision letter for "PDGF receptor signaling in osteoblast lineage cells controls bone resorption through up‐regulation of Csf1 expression"

10.1002/jbmr.4150/v3/decision1 ◽

2020 ◽

Keyword(s):

Bone Resorption ◽

Receptor Signaling ◽

Osteoblast Lineage

Faculty Opinions recommendation of Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14039976.793489435 ◽

2014 ◽

Author(s):

Johanne Martel-Pelletier ◽

Mohit Kapoor

Keyword(s):

Osteoclast Precursors ◽

Osteoblast Lineage

Faculty Opinions recommendation of Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14039976.789952853 ◽

2012 ◽

Author(s):

Shiro Ikegawa

Keyword(s):

Osteoclast Precursors ◽

Osteoblast Lineage

Faculty Opinions recommendation of Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14039976.15500082 ◽

2012 ◽

Author(s):

Maripat Corr

Keyword(s):

Osteoclast Precursors ◽

Osteoblast Lineage

Enhanced Androgen Signaling with Androgen Receptor Overexpression in the Osteoblast Lineage Controls Skeletal Turnover, Matrix Quality and Bone Architecture

10.21236/ada524383 ◽

2008 ◽

Author(s):

Kristine M. Wiren ◽

Russell Turner

Keyword(s):

Androgen Receptor ◽

Bone Architecture ◽

Matrix Quality ◽

Osteoblast Lineage

Osteoinductive effect of soluble transforming growth factor beta receptor 3 on human osteoblast lineage

Journal of Cellular Biochemistry ◽

10.1002/jcb.29888 ◽

2021 ◽

Author(s):

Angelica Mastandrea Amanso ◽

Archana Kamalakar ◽

Sara Bitarafan ◽

Shelly Abramowicz ◽

Hicham Drissi ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Human Osteoblast ◽

Beta Receptor ◽

Growth Factor Beta ◽

Osteoblast Lineage

A Novel Transgenic Mouse Model to Study the Osteoblast Lineage in Vivo

Annals of the New York Academy of Sciences ◽

10.1196/annals.1402.060 ◽

2007 ◽

Vol 1116 (1) ◽

pp. 149-164 ◽

Cited By ~ 40

Author(s):

C. MAES ◽

T. KOBAYASHI ◽

H. M. KRONENBERG

Keyword(s):

Mouse Model ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Osteoblast Lineage

Differential temporal effects of sclerostin antibody and parathyroid hormone on cancellous and cortical bone and quantitative differences in effects on the osteoblast lineage in young intact rats

Bone ◽

10.1016/j.bone.2015.08.007 ◽

2015 ◽

Vol 81 ◽

pp. 380-391 ◽

Cited By ~ 39

Author(s):

Michael S. Ominsky ◽

Danielle L. Brown ◽

Gwyneth Van ◽

David Cordover ◽

Efrain Pacheco ◽

...

Keyword(s):

Parathyroid Hormone ◽

Cortical Bone ◽

Temporal Effects ◽

Sclerostin Antibody ◽

Osteoblast Lineage ◽

Intact Rats

Faculty Opinions recommendation of Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1119572.575786 ◽

2008 ◽

Author(s):

Andrew Wagner

Keyword(s):

Metastatic Osteosarcoma ◽

Osteoblast Lineage

Heterogeneity of murine periosteum osteochondroprogenitors involved in fracture healing

10.1101/2020.06.24.169003 ◽

2020 ◽

Author(s):

Brya G Matthews ◽

Francesca V Sbrana ◽

Sanja Novak ◽

Jessica L. Funnell ◽

Ye Cao ◽

...

Keyword(s):

Fracture Healing ◽

Progenitor Cells ◽

Progenitor Cell ◽

Callus Formation ◽

Lineage Tracing ◽

Fracture Callus ◽

Stem And Progenitor Cells ◽

Periosteal Cells ◽

Osteoblast Lineage

AbstractThe periosteum is the major source of cells involved in fracture healing. We sought to characterize differences in progenitor cell populations between periosteum and other bone compartments, and identify periosteal cells involved in fracture healing. The periosteum is highly enriched for progenitor cells, including Sca1+ cells, CFU-F and label-retaining cells. Lineage tracing with αSMACreER identifies periosteal cells that contribute to >80% of osteoblasts and ~40% of chondrocytes following fracture. A subset of αSMA+ cells are quiescent long-term injury-responsive progenitors. Ablation of αSMA+ cells impairs fracture callus formation. In addition, committed osteoblast-lineage cells contributed around 10% of osteoblasts, but no chondrocytes in fracture calluses. Most periosteal progenitors, particularly those that form osteoblasts, can be targeted by αSMACreER. We have demonstrated that the periosteum is highly enriched for skeletal stem and progenitor cells and there is heterogeneity in the populations of cells that contribute to mature lineages during periosteal fracture healing.