Adolescent cannabis use and later development of schizophrenia: An updated systematic review of longitudinal studies

BackgroundIt is unclear if research findings support clinical opinion that cannabis use leads to worse outcomes in people with psychosis, or whether this impression is confounded by other factors.AimsTo systematically review the evidence pertaining to whether cannabis affects outcome of psychotic disorders.MethodWe searched 10 relevant databases (to November 2006), reference lists of included studies and contacted experts. We included 13 longitudinal studies from 15 303 references. Data extraction and quality assessment were conducted independently and in duplicate.ResultsCannabis use was consistently associated with increased relapse and non-adherence. Associations with other outcome measures were more disparate. Few studies adjusted for baseline illness severity, and most made no adjustment for alcohol, or other potentially important confounders. Adjusting for even a few confounders often resulted in substantial attenuation of results.ConclusionsConfidence that most associations reported were specifically due to cannabis is low. Despite clinical opinion, it remains important to establish whether cannabis is harmful, what outcomes are particularly susceptible, and how such effects are mediated. Studies to examine this further are eminently feasible.

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892 – The association between cannabis use and depression: a systematic review and meta-analysis of longitudinal studies

European Psychiatry ◽

10.1016/s0924-9338(13)76057-7 ◽

2013 ◽

Vol 28 ◽

pp. 1 ◽

Cited By ~ 2

Author(s):

S. Lev-Ran ◽

M. Roerecke ◽

B. Le Foll ◽

T. George ◽

K. McKenzie ◽

...

Keyword(s):

Systematic Review ◽

Longitudinal Studies ◽

Meta Analysis ◽

Cannabis Use

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Intelligence Quotient Decline Following Frequent or Dependent Cannabis Use in Adolescence: A Systematic Review and Meta-Analysis of Longitudinal Studies

SSRN Electronic Journal ◽

10.2139/ssrn.3582784 ◽

2020 ◽

Author(s):

Emmet Power ◽

Sophie Sabherwal ◽

Colm Healy ◽

Aisling O'Neill ◽

David Cotter ◽

...

Keyword(s):

Systematic Review ◽

Longitudinal Studies ◽

Intelligence Quotient ◽

Meta Analysis ◽

Cannabis Use

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Cannabis-associated arteritis

VASA ◽

10.1024/0301-1526/a000004 ◽

2010 ◽

Vol 39 (1) ◽

pp. 43-53 ◽

Cited By ~ 17

Author(s):

Grotenhermen

Keyword(s):

Systematic Review ◽

Case Reports ◽

Case Series ◽

Cardiovascular Effects ◽

Causative Factor ◽

Cannabis Use ◽

Thromboangiitis Obliterans ◽

Pathological Features ◽

Scientific Support ◽

Clinical And Pathological Features

Background: To investigate the hypothesis that cases of arteritis similar to thromboangiitis obliterans (TAO) and associated with the use of cannabis were caused by cannabis or THC (dronabinol), or that cannabis use is a co-factor of TAO. Patients and methods: A systematic review on case reports and the literature on so-called cannabis arteritis, TAO, and cardiovascular effects of cannabinoids was conducted. Results: Fifteen reports with 57 cases of an arteritis associated with the use of cannabis and two additional case series of TAO, in which some patients also used cannabis, were identified. Clinical and pathological features of cannabis-associated arteritis do not differ from TAO and the major risk factor of TAO, tobacco use, was present in most, if not in all of these cases. The proposed pathophysiological mechanisms for the development of an arteritis by cannabis use are not substantiated. Conclusions: The hypothesis of cannabis being a causative factor or co-factor of TAO or an arteritis similar to TAO is not supported by the available evidence. The use of the term cannabis arteritis should be avoided until or unless more convincing scientific support is forthcoming.

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