Comparative studies of the granulopoietic enhancing effects of biosynthetic human insulin-like growth factors I and II

1993 ◽  
Vol 157 (1) ◽  
pp. 178-183 ◽  
Author(s):  
Shoshana Merchav ◽  
Mats Lake ◽  
Anna Skottner
Keyword(s):  
Growth Factors ◽  
Human Insulin ◽  
Comparative Studies ◽  
Biosynthetic Human Insulin ◽  
Insulin Like Growth Factors

An Improved Method for the Purification of Human Insulin-Like Growth Factors I and II*

Endocrinology ◽  
1986 ◽  
Vol 118 (5) ◽  
pp. 2034-2038 ◽  
Author(s):  
PETRO E. PETRIDES ◽  
RAYMOND L. HINTZ ◽  
PETER BOHLEN ◽  
JOHN E. SHIVELY
Keyword(s):  
Growth Factors ◽  
Human Insulin ◽  
Improved Method ◽  
Insulin Like Growth Factors

scholarly journals Human insulin-like growth factors I and II (IGF-I, IGF-II) are synthesized as precursors

1984 ◽  
Vol 18 (11) ◽  
pp. 1206-1206 ◽  
Author(s):  
M Jansen ◽  
H H M Van Tol ◽  
F M A Van Schaik ◽  
J L Van Den Brande ◽  
J S Sussenbach
Keyword(s):  
Growth Factors ◽  
Human Insulin ◽  
Igf I ◽  
Insulin Like Growth Factors

An effective method for the separation of insulin-like growth factors 1 and 2 during the purification process

1988 ◽  
Vol 8 (3) ◽  
pp. 293-297 ◽  
Author(s):  
M. Tally ◽  
K. Florell ◽  
G. Enberg
Keyword(s):  
Growth Factors ◽  
Human Insulin ◽  
Cation Exchanger ◽  
Radioreceptor Assay ◽  
Cross Reaction ◽  
Purification Process ◽  
Purification Step ◽  
Igf Receptor ◽  
Insulin Like Growth Factors

The separation of human insulin-like growth factors hIGF-1 and hIGF-2 was greatly improved by an additional purification step using the cation exchanger Mono-S (FPLC) compared to previous studies. Cross-reactions between hIFG-1 and hIGF-2 were strongly reduced. The more highly purified hIGF-1 had a cross-reaction of less than 1% in the RIA for hIGF-2, and was equivalent to recombinant hIGF-1. The pure hIGF-2 had a cross-reaction of less than 1% in the RIA for hIGF-1. In the human placental hIGF-2 radioreceptor assay, the hIGF-1 polypeptide competed less than 1% with hIGF-2 when the type 1 IGF receptor was blocked with insulin.

Degradation Of Insulin-Like Growth Factors I And II By A Human Insulin Degrading Enzyme

1984 ◽  
Vol 10 (2) ◽  
pp. 101-112 ◽  
Author(s):  
Richard A. Roth ◽  
Mary L. Mesirow ◽  
Koichi Yokono ◽  
Shigeaki Baba
Keyword(s):  
Growth Factors ◽  
Human Insulin ◽  
Insulin Degrading Enzyme ◽  
Degrading Enzyme ◽  
Insulin Like Growth Factors
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