scholarly journals Contextual extinction of drug‐associated discriminative stimuli fails to attenuate drug‐vs‐food choice in rhesus monkeys

2022 ◽  
Author(s):  
Matthew L. Banks ◽  
Blake A. Hutsell ◽  
S. Stevens Negus
Keyword(s):  
Food Choice ◽  
Rhesus Monkeys ◽  
Discriminative Stimuli

scholarly journals Extinguishing cocaine-associated discriminative stimuli attenuates cocaine vs food choice in male rhesus monkeys

2019 ◽  
Author(s):  
Matthew L Banks ◽  
Blake A. Hutsell ◽  
S Stevens Negus
Keyword(s):  
Food Choice ◽  
Rhesus Monkeys ◽  
Fixed Ratio ◽  
Concurrent Schedule ◽  
Food Delivery ◽  
Self Administration ◽  
Discriminative Stimuli ◽  
Choice Procedure ◽  
Choice Procedures ◽  
Male Rhesus

ABSTRACTBackgroundIn drug addiction, relapse can be triggered by cues that function as discriminative stimuli to signal contingencies of drug availability and promote drug-taking behavior. Extinction procedures can weaken the association between drug-associated cues and drug use and may reduce the probability of relapse. This study evaluated effects of a regimen of extinction training on cocaine self-administration maintained in rhesus monkeys under a cocaine-vs.-food choice procedure that has been used previously to evaluate effectiveness of other candidate treatments for cocaine abuse.MethodsBehavior was initially maintained under a concurrent schedule of food delivery (1-g food pellets; fixed-ratio 100 schedule) and cocaine injections (0-0.1 mg/kg/injection; fixed-ratio 10 schedule) during daily 2-h choice sessions in male rhesus monkeys (n=4). Subsequently, choice sessions were supplemented by daily 20-h extinction sessions for 14 consecutive days. During extinction sessions, cocaine-associated discriminative stimuli were presented, but responding did not produce cocaine injections. Cocaine continued to be available during choice sessions.ResultsPrior to extinction, cocaine maintained a dose-dependent increase in cocaine vs. food choice. Responding during extinction sessions declined to low levels by the fifth day. Exposure to extinction sessions produced a more gradual but significant decline in cocaine choice and a complementary increase in food choice during choice sessions.ConclusionsThese preclinical results support the effectiveness of extinguishing cocaine-associated discriminative stimuli as a non-pharmacological treatment strategy for reducing cocaine choice. Moreover, these results also support the construct validity of preclinical drug vs. food choice procedures as a tool for candidate treatment evaluation for cocaine addiction.

scholarly journals Effects of Phendimetrazine Treatment on Cocaine vs Food Choice and Extended-Access Cocaine Consumption in Rhesus Monkeys

2013 ◽  
Vol 38 (13) ◽  
pp. 2698-2707 ◽  
Author(s):  
Matthew L Banks ◽  
Bruce E Blough ◽  
Timothy R Fennell ◽  
Rodney W Snyder ◽  
S Stevens Negus
Keyword(s):  
Food Choice ◽  
Rhesus Monkeys ◽  
Extended Access

scholarly journals Delay discounting of food by rhesus monkeys: Cocaine and food choice in isomorphic and allomorphic situations.

2015 ◽  
Vol 23 (3) ◽  
pp. 184-193 ◽  
Author(s):  
Sally L. Huskinson ◽  
William L. Woolverton ◽  
Leonard Green ◽  
Joel Myerson ◽  
Kevin B. Freeman
Keyword(s):  
Delay Discounting ◽  
Food Choice ◽  
Rhesus Monkeys

scholarly journals Effects of the kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) on cocaine versus food choice and extended-access cocaine intake in rhesus monkeys

2015 ◽  
Vol 21 (2) ◽  
pp. 360-373 ◽  
Author(s):  
Blake A. Hutsell ◽  
Kejun Cheng ◽  
Kenner C. Rice ◽  
Sidney Stevens Negus ◽  
Matthew L. Banks
Keyword(s):  
Receptor Antagonist ◽  
Opioid Receptor ◽  
Food Choice ◽  
Rhesus Monkeys ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Opioid Receptor Antagonist ◽  
Extended Access
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