Interrelationships of ultrastructure and function in the microvasculature of normal and ischaemic myocardium

1991 ◽  
Vol 19 (4) ◽  
pp. 429-438 ◽  
Author(s):  
John Bevan Gavin ◽  
Linda Maxwell ◽  
Martin David Sage
Keyword(s):  
Ischaemic Myocardium ◽  
Ultrastructure And Function ◽  
And Function

scholarly journals Alterations in flight muscle ultrastructure and function in Drosophila tropomyosin mutants.

1996 ◽  
Vol 135 (3) ◽  
pp. 673-687 ◽  
Author(s):  
A J Kreuz ◽  
A Simcox ◽  
D Maughan
Keyword(s):  
Amino Acid ◽  
Power Output ◽  
Flight Muscle ◽  
Structure And Function ◽  
Wild Type ◽  
Muscle Tropomyosin ◽  
Ultrastructure And Function ◽  
And Function ◽  
Net Power Output ◽  
Current Report

Drosophila indirect flight muscle (IFM) contains two different types of tropomyosin: a standard 284-amino acid muscle tropomyosin, Ifm-TmI, encoded by the TmI gene, and two > 400 amino acid tropomyosins, TnH-33 and TnH-34, encoded by TmII. The two IFM-specific TnH isoforms are unique tropomyosins with a COOH-terminal extension of approximately 200 residues which is hydrophobic and rich in prolines. Previous analysis of a hypomorphic TmI mutant, Ifm(3)3, demonstrated that Ifm-TmI is necessary for proper myofibrillar assembly, but no null TmI mutant or TmII mutant which affects the TnH isoforms have been reported. In the current report, we show that four flightless mutants (Warmke et al., 1989) are alleles of TmI, and characterize a deficiency which deletes both TmI and TmII. We find that haploidy of TmI causes myofibrillar disruptions and flightless behavior, but that haploidy of TmII causes neither. Single fiber mechanics demonstrates that power output is much lower in the TmI haploid line (32% of wild-type) than in the TmII haploid line (73% of wild-type). In myofibers nearly depleted of Ifm-TmI, net power output is virtually abolished (< 1% of wild-type) despite the presence of an organized fibrillar core (approximately 20% of wild-type). The results suggest Ifm-TmI (the standard tropomyosin) plays a key role in fiber structure, power production, and flight, with reduced Ifm-TmI expression producing corresponding changes of IFM structure and function. In contrast, reduced expression of the TnH isoforms has an unexpectedly mild effect on IFM structure and function.

Essential thrombocythemia in a child: Platelet ultrastructure and function

1980 ◽  
Vol 8 (1) ◽  
pp. 87-107 ◽  
Author(s):  
Marion I. Barnhart ◽  
Tae H. Kim ◽  
Bruce L. Evatt ◽  
Abdelsalam H. Ragab ◽  
Victor K. Lui ◽  
...  
Keyword(s):  
Essential Thrombocythemia ◽  
Ultrastructure And Function ◽  
And Function

scholarly journals Ultrastructure and function of mitochondria in gametocytic stage ofPlasmodium falciparum

Parasite ◽  
2000 ◽  
Vol 7 (1) ◽  
pp. 19-26 ◽  
Author(s):  
J. Krungkrai ◽  
P. Prapunwattana ◽  
S.R. Krungkrai
Keyword(s):  
Ofplasmodium Falciparum ◽  
Ultrastructure And Function ◽  
And Function

scholarly journals Ultrastructure and Function of Sertoli Cell Processes in the Korean Native Goat.

2002 ◽  
Vol 79 (4) ◽  
pp. 121-127 ◽  
Author(s):  
Geon Oh KWON ◽  
Young Seok PARK ◽  
Seong Ho LEE ◽  
Etsuko YAMAMOTO ◽  
Yoshinao HOSAKA ◽  
...  
Keyword(s):  
Sertoli Cell ◽  
Cell Processes ◽  
Ultrastructure And Function ◽  
And Function

scholarly journals Primary Cilium in Cancer Hallmarks

2019 ◽  
Vol 20 (6) ◽  
pp. 1336 ◽  
Author(s):  
Lucilla Fabbri ◽  
Frédéric Bost ◽  
Nathalie Mazure
Keyword(s):  
Cancer Progression ◽  
Primary Cilium ◽  
Mammalian Cells ◽  
Current Knowledge ◽  
Wide Spectrum ◽  
Cancer Hallmarks ◽  
Mutual Regulation ◽  
Ultrastructure And Function ◽  
And Function ◽  
External Stimuli

The primary cilium is a solitary, nonmotile and transitory appendage that is present in virtually all mammalian cells. Our knowledge of its ultrastructure and function is the result of more than fifty years of research that has dramatically changed our perspectives on the primary cilium. The mutual regulation between ciliogenesis and the cell cycle is now well-recognized, as well as the function of the primary cilium as a cellular “antenna” for perceiving external stimuli, such as light, odorants, and fluids. By displaying receptors and signaling molecules, the primary cilium is also a key coordinator of signaling pathways that converts extracellular cues into cellular responses. Given its critical tasks, any defects in primary cilium formation or function lead to a wide spectrum of diseases collectively called “ciliopathies”. An emerging role of primary cilium is in the regulation of cancer development. In this review, we seek to describe the current knowledge about the influence of the primary cilium in cancer progression, with a focus on some of the events that cancers need to face to sustain survival and growth in hypoxic microenvironment: the cancer hallmarks.

GLP-1 could improve the similarity of IPCs and pancreatic beta cells in cellular ultrastructure and function

2013 ◽  
Vol 114 (10) ◽  
pp. 2221-2230
Author(s):  
Qiping Shi ◽  
Simin Luo ◽  
Haiying Jia ◽  
Lie Feng ◽  
Xiaohua Lu ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Cellular Ultrastructure ◽  
Ultrastructure And Function ◽  
And Function
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