Effects of excitatory amino acids on in vivo and in vitro gonadotropin and growth hormone secretion in testosterone-primed immature rainbow trout,Oncorhynchus mykiss

1994 ◽  
Vol 268 (5) ◽  
pp. 390-399 ◽  
Author(s):  
Peter A. Flett ◽  
Glen van der Kraak ◽  
John F. Leatherland
Endocrine ◽  
2005 ◽  
Vol 28 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Enrique Aguilar ◽  
Manuel Tena-Sempere ◽  
Leonor Pinilla

1980 ◽  
Vol 93 (2) ◽  
pp. 134-138 ◽  
Author(s):  
M. Donnadieu ◽  
R. M. Schimpff ◽  
P. Garnier ◽  
J. L. Chaussain ◽  
J. C. Job

Abstract. Since transferrin (Tf) in vitro has a growth-promoting activity and is associated with NSILA properties, the aim of this work was to study in vivo the relationships between Tf, somatomedin activity (SM), growth hormone (GH) secretion, and height velocity in children. An iv infusion of ornithine hydrochloride was given to 23 controls; the induced rise of GH was accompanied by a simultaneous fall of SM (r = −0.711, P < 0.001) and was preceded by a fall of Tf (r = −0.610, P < 0.01). In 17 obese children SM was within the normal range, when Tf levels were higher and arginineinduced GH peaks lower than in the controls, and a negative correlation was found between Tf basal levels and GH peaks (r = −0.608, P < 0.01). In 9 children with confirmed hypopituitarism the Tf levels were significantly lower than in the controls. In 14 children with confirmed or suspected hypopituitarism a single im injection of hGH (6 mg) failed to induce Tf variations over 24 h. In 39 of these children the height velocity was significantly correlated with Tf basal levels (r = 0.701, P < 0.001). These data suggest that transferrin is involved in growth regulation, and that GH secretion is related to transferrin levels by a feed-back mechanism.


1987 ◽  
Vol 114 (4) ◽  
pp. 465-469 ◽  
Author(s):  
Gian Paolo Ceda ◽  
Robert G. Davis ◽  
Andrew R. Hoffman

Abstract. Glucocorticoids have been shown to have both stimulatory and suppressive effects on GH secretion in vitro and in vivo. In order to study the kinetics of glucocorticoid action on the somatotrope, cultured rat pituitary cells were exposed to dexamethasone for varying periods of time. During short-term incubations (≤ 4 h), dexamethasone inhibited GHRH and forskolin-elicited GH secretion, but during longer incubation periods, the glucocorticoid enhanced both basal and GHRH-stimulated GH release. The inhibitory effect of brief dexamethasone exposure was also seen in cells which previously had been exposed to dexamethasone. In addition, growth hormone secretion from cultured rat and human somatotropinoma cells was inhibited by a brief exposure to dexamethasone. Thus, the nature of glucocorticoid action on the isolated cultured somatotrope is biphasic, with brief exposure inhibiting, and more prolonged exposure stimulating GH secretion.


2001 ◽  
Vol 73 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Virginie Tolle ◽  
Philippe Zizzari ◽  
Catherine Tomasetto ◽  
Marie-Christine Rio ◽  
Jacques Epelbaum ◽  
...  

2017 ◽  
Vol 98 (2) ◽  
pp. 559-565 ◽  
Author(s):  
Ali Ehsani ◽  
Mohammad Sedigh Jasour ◽  
Naser Agh ◽  
Mohammad Hashemi ◽  
Mahdi Khodadadi

2011 ◽  
Vol 27 (10) ◽  
pp. 573-582 ◽  
Author(s):  
Abigail E. Bartram ◽  
Matthew J. Winter ◽  
Duane B. Huggett ◽  
Paul McCormack ◽  
Lisa A. Constantine ◽  
...  

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