Isatin–Coumarin Hybrids Tethered via Diethylene Glycol: Design, Synthesis, and Their In Vitro Antitumor Activities

2018 ◽  
Vol 55 (12) ◽  
pp. 2722-2726 ◽  
Author(s):  
Yi‐Lei Fan ◽  
Zhong‐Ping Huang ◽  
Min Liu
Keyword(s):  
Diethylene Glycol ◽  
Antitumor Activities ◽  
Design Synthesis

Design, synthesis, and biological evaluation of new series of 2-amido-1,3,4-thiadiazole derivatives as cytotoxic agents

2016 ◽  
Vol 71 (3) ◽  
pp. 205-210 ◽  
Author(s):  
Ali Almasirad ◽  
Loghman Firoozpour ◽  
Maliheh Nejati ◽  
Najmeh Edraki ◽  
Omidreza Firuzi ◽  
...  
Keyword(s):  
Human Tumor ◽  
Inhibitory Effect ◽  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Antitumor Activities ◽  
Design Synthesis ◽  
Ethidium Bromide Staining ◽  
Thiadiazole Derivatives ◽  
Synthesis And Biological Evaluation

AbstractA series of novel 1,3,4-thiadiazole derivatives bearing an amide moiety were designed, synthesized, and evaluated for their in vitro antitumor activities against HL-60, SKOV-3 and MOLT-4 human tumor cell lines by MTT assay. Ethyl 2-((5-(4-methoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5f) showed the best inhibitory effect against SKOV-3 cells, with an IC50 value of 19.5 μm. In addition, the acridine orange/ethidium bromide staining assay in SKOV-3 cells suggested that the cytotoxic activity of 5f occurs via apoptosis.

Design, synthesis and in vitro and in vivo antitumor activities of novel bivalent β-carbolines

2013 ◽  
Vol 60 ◽  
pp. 10-22 ◽  
Author(s):  
Buxi Shi ◽  
Rihui Cao ◽  
Wenxi Fan ◽  
Liang Guo ◽  
Qin Ma ◽  
...  
Keyword(s):  
Antitumor Activities ◽  
Design Synthesis

scholarly journals Design, Synthesis, and Preliminary Antitumor Activity Evaluation of Novel Alkaloid Derivatives

2020 ◽  
Vol 15 (2) ◽  
pp. 1934578X2090353
Author(s):  
Li-Jiao Wang ◽  
Zhi-Xing Cao ◽  
Li Guo
Keyword(s):  
Antitumor Activity ◽  
Scaffold Hopping ◽  
Antitumor Activities ◽  
Design Synthesis ◽  
Tetrazolium Bromide ◽  
Activity Evaluation ◽  
H460 Cells

A novel alkaloid scaffold was designed through scaffold-hopping strategy based on the active pyrazines alkaloid isolated previously. A total of 25 derivatives were synthesized based on this scaffold and evaluated for their antitumor activities. Among all these tested compounds, 9f exhibited most excellent antitumor activities toward H460 cells, TMD-8 cells, and MV4-11 cells in vitro by 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetrazolium bromide assay with IC50 values of 29.8, 14.9, and 18.8 μM, respectively.

Design, Synthesis, and In Vitro Antileishmanial and Antitumor Activities of New Tetrahydroquinolines

2017 ◽  
Vol 55 (2) ◽  
pp. 391-401 ◽  
Author(s):  
Hassan Mohamed Fawzy Madkour ◽  
Maher Abd El-Aziz Mahmoud El-Hashash ◽  
Marwa Sayed Salem ◽  
Al-Shimaa Omar Ali Mahmoud ◽  
Yasser M. S. A. Al kahraman
Keyword(s):  
Antitumor Activities ◽  
Design Synthesis

Design, Synthesis and in vitro and in vivo Antitumor Activities of Novel β-Carboline Derivatives.

ChemInform ◽  
2006 ◽  
Vol 37 (8) ◽  
Author(s):  
R. Cao ◽  
H. Chen ◽  
W. Peng ◽  
Y. Ma ◽  
X. Hou ◽  
...  
Keyword(s):  
Antitumor Activities ◽  
Design Synthesis

Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives

2005 ◽  
Vol 40 (10) ◽  
pp. 991-1001 ◽  
Author(s):  
R. Cao ◽  
H. Chen ◽  
W. Peng ◽  
Y. Ma ◽  
X. Hou ◽  
...  
Keyword(s):  
Antitumor Activities ◽  
Design Synthesis

Design, synthesis and biological evaluation of a novel series of glycosylated platinum(iv) complexes as antitumor agents

2016 ◽  
Vol 45 (25) ◽  
pp. 10366-10374 ◽  
Author(s):  
Qingpeng Wang ◽  
Zhonglv Huang ◽  
Jing Ma ◽  
Xiaolin Lu ◽  
Li Zhang ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Antitumor Activities ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

A new series of glycosylated Pt(iv) complexes were designed, synthesized and evaluated for antitumor activities in vitro and in vivo.

Design, Synthesis and Biological Evaluation of Sunitinib Analogues to Improve Aqueous Solubility

2013 ◽  
Vol 749 ◽  
pp. 350-353 ◽  
Author(s):  
Ke Tao Chen ◽  
Zheng Fang ◽  
Zhao Yang ◽  
Kai Guo
Keyword(s):  
Aqueous Solubility ◽  
Positive Control ◽  
Biological Evaluation ◽  
Antitumor Activities ◽  
Design Synthesis ◽  
H Nmr ◽  
Mtt Method ◽  
Antitumor Bioactivity ◽  
Synthesis And Biological Evaluation

In order to improve aqueous solubility of Sunitinib, based on the structure-activity relationship, four analogues were designed and synthesized. The obtained structures were identified by1H NMR, MS and elemental analysis.In vitroevaluation of antitumor bioactivity was performed by MTT method. All of synthesized compounds showed antitumor activities, especially, compounds A1, which were better than or equal to the antitumor activity of positive control.

Sign in / Sign up

Export Citation Format

Share Document