Discovery of 4 H ‐thieno[3,2‐ b ]pyrrole derivatives as potential anticancer agents

ChemInform Abstract: Ultrasound-Assisted Bismuth Nitrate-Induced Green Synthesis of Novel Pyrrole Derivatives and Their Biological Evaluation as Anticancer Agents.

ChemInform ◽

10.1002/chin.201235104 ◽

2012 ◽

Vol 43 (35) ◽

pp. no-no

Author(s):

Debasish Bandyopadhyay ◽

Sanghamitra Mukherjee ◽

Jose C. Granados ◽

John D. Short ◽

Bimal K. Banik

Keyword(s):

Green Synthesis ◽

Anticancer Agents ◽

Biological Evaluation ◽

Bismuth Nitrate ◽

Pyrrole Derivatives ◽

Ultrasound Assisted

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Pyrrole as an Important Scaffold of Anticancer Drugs: Recent Advances

Journal of Pharmacy & Pharmaceutical Sciences ◽

10.18433/jpps32417 ◽

2022 ◽

Vol 25 ◽

pp. 24-40

Author(s):

Emilio Mateev ◽

Maya Georgieva ◽

Alexander Zlatkov

Keyword(s):

Anticancer Drugs ◽

Anticancer Agents ◽

Tyrosine Kinases ◽

Lipid Lowering ◽

Pyrrole Derivatives ◽

Design And Synthesis ◽

Anticancer Properties ◽

Highly Active ◽

Recent Advances ◽

Cytochrome P450 Family

With the significant increase of patients suffering from different types of cancer, it is evident that prompt measures in the development of novel and effective agents need to be taken. Pyrrole moiety has been found in various active compounds with anti-inflammatory, antiseptic, antibacterial, lipid-lowering and anticancer properties. Recent advances in the exploration of highly active and selective cytotoxic structures containing pyrrole motifs have shown promising data for future investigations. Accordingly, this review presents an overview of recent developments in the pyrrole derivatives as anticancer agents, with a main focus towards the key moieties required for the anti-tumor activities. Pyrrole molecules comprising prominent targeting capacities against microtubule polymerization, tyrosine kinases, cytochrome p450 family 1, histone deacetylase and bcl-2 proteins were reported. In addition, several mechanisms of action, such as apoptosis, cell cycle arrest, inhibiting kinases, angiogenesis, disruption of cell migration, modulation of nuclear receptor responsiveness and others were analyzed. Furthermore, in most of the discussed cases we provided synthesis schemes of the mentioned molecules. Overall, the utilization of pyrrole scaffold for the design and synthesis of novel anticancer drugs could be a promising approach for future investigations.

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