ChemInform Abstract: Ultrasound-Assisted Bismuth Nitrate-Induced Green Synthesis of Novel Pyrrole Derivatives and Their Biological Evaluation as Anticancer Agents.

ChemInform ◽  
2012 ◽  
Vol 43 (35) ◽  
pp. no-no
Author(s):  
Debasish Bandyopadhyay ◽  
Sanghamitra Mukherjee ◽  
Jose C. Granados ◽  
John D. Short ◽  
Bimal K. Banik
Keyword(s):  
Green Synthesis ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Bismuth Nitrate ◽  
Pyrrole Derivatives ◽  
Ultrasound Assisted

Ultrasound-assisted bismuth nitrate-induced green synthesis of novel pyrrole derivatives and their biological evaluation as anticancer agents

2012 ◽  
Vol 50 ◽  
pp. 209-215 ◽  
Author(s):  
Debasish Bandyopadhyay ◽  
Sanghamitra Mukherjee ◽  
Jose C. Granados ◽  
John D. Short ◽  
Bimal K. Banik
Keyword(s):  
Green Synthesis ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Bismuth Nitrate ◽  
Pyrrole Derivatives ◽  
Ultrasound Assisted

scholarly journals Ultrasound-assisted PSA catalyzed one-pot green synthesis of pyrazolyl pyrrole derivatives

2020 ◽  
Author(s):  
G. Mohan ◽  
N. Saichaitanya ◽  
S. Murali ◽  
N. Bakthavatchala Reddy ◽  
Grigory V. Zyryanov ◽  
...  
Keyword(s):  
Green Synthesis ◽  
One Pot ◽  
Pyrrole Derivatives ◽  
Ultrasound Assisted

scholarly journals Green synthesis and biological evaluation of novel 5-fluorouracil derivatives as potent anticancer agents

2019 ◽  
Vol 27 (8) ◽  
pp. 1164-1173 ◽  
Author(s):  
Farhat Jubeen ◽  
Aisha Liaqat ◽  
Misbah Sultan ◽  
Sania Zafar Iqbal ◽  
Imran Sajid ◽  
...  
Keyword(s):  
Green Synthesis ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Green synthesis and biological evaluation of some new benzothiazolo [2,3-b] quinazolin-1-ones as anticancer agents

2014 ◽  
Vol 23 (11) ◽  
pp. 4893-4900 ◽  
Author(s):  
Jaiprakash N. Sangshetti ◽  
Deepak K. Lokwani ◽  
Rashmi S. Chouthe ◽  
Ashok Ganure ◽  
Bhuvan Raval ◽  
...  
Keyword(s):  
Green Synthesis ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME 2-ARYLBENZOXAZOLE ACETIC ACID DERIVATIVES AS PROMISING ANTICANCER AGENTS

2020 ◽  
Vol 77 (5) ◽  
pp. 717-723
Author(s):  
Qais Abualassal ◽  
Jamal Jilani ◽  
Areej Assaf ◽  
Reham Abu shmies
Keyword(s):  
Acetic Acid ◽  
Anticancer Agents ◽  
Biological Evaluation

Synthesis and Biological Evaluation of 1,3,4-Thiadiazole Linked Phthalimide Derivatives as Anticancer Agents

2017 ◽  
Vol 14 (10) ◽  
Author(s):  
Zahra Rezaei ◽  
Setareh Moghimi ◽  
Rezvan Javaheri ◽  
Mehdi Asadi ◽  
Mohammad Mahdavi ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of Novel 4,5,6,7-Tetrahydrobenzo[D]-Thiazol-2- Yl Derivatives Derived from Dimedone with Anti-Tumor, C-Met, Tyrosine Kinase and Pim-1 Inhibitions

2019 ◽  
Vol 19 (12) ◽  
pp. 1438-1453 ◽  
Author(s):  
Rafat M. Mohareb ◽  
Amr S. Abouzied ◽  
Nermeen S. Abbas
Keyword(s):  
Tyrosine Kinase ◽  
Tumor Cell ◽  
Cell Lines ◽  
Single Molecule ◽  
Anticancer Agents ◽  
Biological Evaluation ◽  
New Drugs ◽  
Tumor Cell Lines ◽  
Thiazole Derivatives ◽  
Wide Range

Background: Dimedone and thiazole moieties are privileged scaffolds (acting as primary pharmacophores) in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. Thiazole derivatives are a very important class of compounds due to their wide range of pharmaceutical and therapeutic activities. On the other hand, dimedone is used to synthesize many therapeutically active compounds. Therefore, the combination of both moieties through a single molecule to produce heterocyclic compounds will produce excellent anticancer agents. Objective: The present work reports the synthesis of 47 new substances belonging to two classes of compounds: Dimedone and thiazoles, with the purpose of developing new drugs that present high specificity for tumor cells and low toxicity to the organism. To achieve this goal, our strategy was to synthesize a series of 4,5,6,7-tetrahydrobenzo[d]-thiazol-2-yl derivatives using the reaction of the 2-bromodimedone with cyanothioacetamide. Methods: The reaction of 2-bromodimedone with cyanothioacetamide gave the 4,5,6,7-tetrahydrobenzo[d]- thiazol-2-yl derivative 4. The reactivity of compound 4 towards some chemical reagents was observed to produce different heterocyclic derivatives. Results: A cytotoxic screening was performed to evaluate the performance of the new derivatives in six tumor cell lines. Thirteen compounds were shown to be promising toward the tumor cell lines which were further evaluated toward five tyrosine kinases. Conclusion: The results of antitumor screening showed that many of the tested compounds were of high inhibition towards the tested cell lines. Compounds 6c, 8c, 11b, 11d, 13b, 14b, 15c, 15g, 21b, 21c, 20d and 21d were the most potent compounds toward c-Met kinase and PC-3 cell line. The most promising compounds 6c, 8c, 11b, 11d, 13b, 14b, 15c, 15g, 20c, 20d, 21b, 21c and 21d were further investigated against tyrosine kinase (c-Kit, Flt-3, VEGFR-2, EGFR, and PDGFR). Compounds 6c, 11b, 11d, 14b, 15c, and 20d were selected to examine their Pim-1 kinase inhibition activity the results revealed that compounds 11b, 11d and 15c had high activities.

Hybridized Quinoline Derivatives as Anticancer Agents: Design, Synthesis, Biological Evaluation and Molecular Docking

2019 ◽  
Vol 19 (4) ◽  
pp. 439-452 ◽  
Author(s):  
Mohamed R. Selim ◽  
Medhat A. Zahran ◽  
Amany Belal ◽  
Moustafa S. Abusaif ◽  
Said A. Shedid ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Anticancer Agents ◽  
Caspase 3 ◽  
Biological Evaluation ◽  
Tubulin Polymerization ◽  
Design Synthesis ◽  
Chemical Structures ◽  
M Phase ◽  
Induced Apoptosis ◽  
Derivatives Of

Objective: Conjugating quinolones with different bioactive pharmacophores to obtain potent anticancer active agents. Methods: Fused pyrazolopyrimidoquinolines 3a-d, Schiff bases 5, 6a-e, two hybridized systems: pyrazolochromenquinoline 7 and pyrazolothiazolidinquinoline 8, different substituted thiazoloquinolines 13-15 and thiazolo[3,2-a]pyridine derivatives 16a-c were synthesized. Their chemical structures were characterized through spectral and elemental analysis, cytotoxic activity on five cancer cell lines, caspase-3 activation, tubulin polymerization inhibition and cell cycle analysis were evaluated. Results: Four compounds 3b, 3d, 8 and 13 showed potent activity than doxorubicin on HCT116 and three compounds 3b, 3d and 8 on HEPG2. These promising derivatives showed increase in the level of caspase-3. The trifloromethylphenyl derivatives of pyrazolopyrimidoquinolines 3b and 3d showed considerable tubulin polymerization inhibitory activity. Both compounds arrested cell cycle at G2/M phase and induced apoptosis. Conclusion: Compounds 3b and 3d can be considered as promising anticancer active agents with 70% of colchicine activity on tubulin polymerization inhibition and represent hopeful leads that deserve further investigation and optimization.

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