Production, quality control, and determination of human absorbed dose of no carrier added177Lu-risedronate for bone pain palliation therapy

PURPOSE: The aim of this study was to evaluate the degree of metastatic bone pain palliation and medullar toxicity associated with samarium-153-EDTMP treatment. METHODS: Seventy-three patients with metastatic bone pain having previously undergone therapy with samarium-153-EDTMP (1 mCi/kg) were retrospectively evaluated. Routine follow-up included pain evaluation and blood counts for 2 months after treatment. Pain was evaluated using a subjective scale (from 0 to 10) before and for 8 weeks after the treatment. Blood counts were obtained before treatment and once a week for 2 months during follow-up. Dosimetry, based upon the urinary excretion of the isotope, was estimated in 41 individuals, and the resulting radiation absorbed doses were correlated with hematological data. RESULTS: Reduction in pain scores of 75% to 100% was obtained in 36 patients (49%), with a decrease of 50% to 75%, 25% to 50%, and 0% to 25% in, respectively, 20 (27%), 10 (14%), and 7 (10%) patients. There was no significant relationship between the pain response and location of the primary tumor (breast or prostate cancer). Mild to moderate myelosuppression was noted in 75.3% of patients, usually with hematological recovery at 8 weeks. The mean bone marrow dose was 347 ± 65 cGy, and only a weak correlation was found between absorbed dose and myelosuppression (Pearson coefficient = .4). CONCLUSIONS: Samarium-153-EDTMP is a valuable method for metastatic bone pain palliation. A mild to moderate and transitory myelosuppression is the main toxicity observed after samarium therapy, showing a weak correlation with dosimetric measures.

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Human absorbed dose estimation for a new 175Yb-phosphonate based on rats data: Comparison with similar bone pain palliation agents

Applied Radiation and Isotopes ◽

10.1016/j.apradiso.2016.06.013 ◽

2016 ◽

Vol 115 ◽

pp. 55-60

Author(s):

Mahdokht Vaez-Tehrani ◽

Samaneh Zolghadri ◽

Hassan Yousefnia ◽

Hossein Afarideh

Keyword(s):

Bone Pain ◽

Absorbed Dose ◽

Pain Palliation ◽

Dose Estimation ◽

Data Comparison ◽

Bone Pain Palliation

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Production, quality control, biological evaluation and biodistribution modeling of Lutetium-177 maltolate as a viable bone pain palliative in skeletal metastasis

Journal of Radioanalytical and Nuclear Chemistry ◽

10.1007/s10967-014-3603-2 ◽

2014 ◽

Vol 303 (1) ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Amir Hakimi ◽

Amir Reza Jalilian ◽

Simindokht Shirvani-Arani ◽

Parandoush Abbasian ◽

Vahid Khoshmaram ◽

...

Keyword(s):

Quality Control ◽

Bone Pain ◽

Skeletal Metastasis ◽

Production Quality ◽

Biological Evaluation ◽

Production Quality Control

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Photometric stereo-based high-speed inline battery electrode inspection

tm - Technisches Messen ◽

10.1515/teme-2021-0024 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Christian Kapeller ◽

Ernst Bodenstorfer

Keyword(s):

Quality Control ◽

System Architecture ◽

High Speed ◽

Shape From Shading ◽

Production Quality ◽

Photometric Stereo ◽

Inspection System ◽

Coating Materials ◽

Production Quality Control ◽

Reconstruction Performance

Abstract Battery technology is a key component in current electric vehicle applications and an important building block for upcoming smart grid technologies. The performance of batteries depends largely on quality control during their production process. Defects introduced in the production of electrodes can lead to degraded performance and, more importantly, to short circuits in final cells, which is highly safety-critical. In this paper, we propose an inspection system architecture that can detect defects, such as missing coating, agglomerates, and pinholes on coated electrodes. Our system is able to acquire valuable production quality control metrics, like surface roughness. By employing photometric stereo techniques, a shape from shading algorithm, our system surmounts difficulties that arise while optically inspecting the black to dark gray battery coating materials. We present in detail the acquisition concept of the proposed system architecture, and analyze its acquisition-, as well as, its surface reconstruction performance in experiments. We carry these out utilizing two different implementations that can operate at a production speed of up to 2000 mm/s at a resolution of 50 µm per pixel. In this work we aim to provide a system architecture that can provide a reliable contribution to ensuring optimal performance of produced battery cells.

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