Processing and Compatibility of Corydalis yanhusuo: Phytochemistry, Pharmacology, Pharmacokinetics, and Safety

Processed and polyherbal formulations (compatibility) are widely used in traditional Chinese medicine (TCM). However, processing and compatibility may alter the efficacy and safety of herbal medicines, and therefore, evaluating the herbal medicines changes after processing and compatibility is important for their safety. Since Corydalis yanhusuo (Y.H.Chou & Chun C.Hsu) W.T.Wang ex Z.Y.Su & C.Y.Wu (Family: Papaveraceae and Genera: Corydalis), a traditional medicinal plant in China, Japan, Korea, and other Asian countries, has been used for treating a wide range of medical conditions, it is an ideal representative of studying the effects of processing and compatibility on efficacy and toxicity. In this paper, information was obtained by searching electronic databases, classic books, PhD and MSc dissertations, local conference papers, and unpublished materials prior to July 2021. We provide a summary of the phytochemistry, pharmacology, pharmacokinetics, quality control, and safety of C. yanhusuo under various processing or compatibility conditions. Based on our findings, vinegar processing is probably the best C. yanhusuo processing method, which could increase the absorption rate of tetrahydropalmatine (THP) in the heart, liver, spleen, lung, and brain tissues and alleviate mice muscle tremors and liver damage caused by C. yanhusuo. These results indicate that processing and compatibility can reduce toxicity and increase the efficacy of C. yanhusuo. The information provides an expanded understanding of the efficacy and toxicity mechanisms of TCM compounds, which is valuable for industrial production quality control and future drug research.

Towards in-situ quality control of conductive printable electronics: a review of possible pathways

Over the past decade, printed electronics (PE) has shown great potential for a wide range of industries, from consumer goods, electronics, aerospace, automotive, pharmaceutical, biomedical, to textiles and fashion. The rapid development of printing technology has been strongly driven by the growth of the PE market and its many applications. Here, we review the latest trends in PE production quality control, focusing on emerging technologies such as terahertz spectroscopy, which may play a key role in the development of smart manufacturing of PE devices in the near future. We also provide a comparison with conventional quality control technologies or off-line measurements, such as four-point probe measurements, atomic force microscopy, optical microscopy, etc.

Assessment of Sandcrete Blocks Quality in Owerri, Imo State, Nigeria

This study assessed the production management practice being adopted in the manufacture of quality sandcrete blocks in selected sampled parts of Owerri municipal, Imo State, Nigeria. Myriads of literature identify sandcrete blocks as a significant material being used in the building & civil engineering practice and assert that its application as a walling material cannot be over emphasized. Sandcrete block manufacturers in Owerri, Imo State were used for the assessment of the quality of their products in line with the Nigeria Industrial Standard (NIS) specifications. The study adopted field sampling, experimentations and work study methods to determine the compressive strength and water absorption rate properties of the selected sampled sandcrete blocks. The results of the study reveals among others that the mean compressive strength values obtained were as low as 1.92N/mm2, and about 17% water absorption rate from sampled commercial blocks. The results obtained did not compare favorably with the NIS specified acceptable minimum standard values. The study therefore underpinned poor production quality control practice as well as lack of impact of regulatory bodies in Imo State as among factors that contributed to the negative results obtained.

Improving the Production Quality Processes at Bread SMEs in Jakarta

The consumption pattern of the people in Indonesia is experiencing a shift. Consumption patterns that are influenced by socio-cultural factors today make people tend to consume food and drinks that are practical and easy to obtain. This pattern began in 2014 until now, making the percentage of food consumption increase by 2.5% per year. Bread is a finished food whose demand pattern has also increased. Due to the development of the middle-class population, an increase in the income of young people, and society's consumption pattern, which is increasingly shifting to a practical urban consumption pattern. The bread industry in Indonesia is still classified as the small and medium enterprises (SME) sector. Small and medium enterprises (SME) is a business sector with a significant impact on improving the economy in developing countries. The products are distributed to offices that work with bakeries and are sold in stores. This shows that the shop production must work quickly to meet consumer demand in the surrounding area. In fulfilling consumer demand, a production quality control process is required in the workstation to reduce defective products. This study aims to carry out a quality control process to reduce faulty products by using a control chart and the concept of kaizen to control and maintain the production process in bread SMEs so that quality and work effectiveness can be realized.

Production de matières premières et fabrication des médicaments à base de plantes médicinales

Les plantes constituent un réservoir pour les pharmacopées du monde. Plusieurs médicaments importants sont fabriqués à partir des substances actives d’origine végétales. En outre de nombreux médicaments modernes ont été fabriqués à partir de ces matières premières. Les plantes médicinales sont utilisées directement sous forme fraîche, sèche ou transformée, stabilisée, ou extrait ou formulée avec d’autres plantes ou excipients de synthèse. Dans tous les cas, la matière végétale utilisée pour fabriquer la forme posologique doit faire preuve de son efficacité, son innocuité et être de qualité conforme aux exigences de la Pharmacopée Européenne pour les phytomédicaments, garantissant ainsi sa sécurité d’emploi. Pour ce faire, l’Organisation Mondiale de la Santé (OMS) a mis à la disposition des états membres des guides et standards permettant d’harmoniser et de sécuriser leur utilisation. Ainsi de nombreux pays africains ont adopté ces outils après des modifications appropriées pour faire progresser la recherche et le développement (R&D) de médicaments à base de plante. Le but de ce travail était de faire une synthèse des différentes étapes de production, de contrôle qualité et de standardisation des matières premières issues des plantes médicinales et des médicaments à base de plantes médicinales.Mots clés : Pharmacopée, médicaments, médecine traditionnelle, sécurité d’emploi, phytomédicaments. English title: Production of raw materials and manufacturing of drugs from medicinal plants Plants are a reservoir for the world's pharmacopoeias. Several important medicines are made from active substances of plant origin. In addition, many modern medicines have been made from these raw materials. Medicinal plants are used directly in fresh, dry or processed, stabilized, or extracted form or formulated with other plants or synthetic excipients. In all cases, the herbal material used to manufacture the dosage form must demonstrate its efficacy, safety and be of a quality that meets the requirements of the European Pharmacopoeia for phytomedicines, thus ensuring its safe use. To this end, the World Health Organization (WHO) has made available to Member States guides and standards to harmonize and secure their use. Thus, many African countries have adopted these tools after appropriate modifications to advance research and development (R&D) of plant-based drugs. The aim of this work was to make a synthesis of the different stages of production, quality control and standardization of raw materials from medicinal plants and herbal medicines.Keywords: Pharmacopoeia, drugs, traditional medicine, safe use, phytomedicines.

RESEARCH ON QUALITY CONTROL METHOD OF LAND COVER CLASSIFICATION DATA ORIENTED TO NATIONAL GEOGRAPHIC CONDITION MONITORING

Aiming at the quality problems of the land cover classification data, such as missing update of changed spots, overrun of spot collection accuracy, incorrect spot classification, and inconsistencies between the filling of the change types of map spots and technical regulations, had been found during the quality inspection of the national geographic condition monitoring in China. This paper analyzed the key production factors, processes and causes that affect the process quality of the land cover classification data, and proposed the concept of the whole production quality control, and discussed the quality control measures to improve the land cover classification product. The research based on the new requirements of the whole-process quality control system in order to solve the quality problem-oriented production quality control method, could improve the quality of land cover classification product and provided reference for the quality control of the production process of related engineering projects in the future.

Photometric stereo-based high-speed inline battery electrode inspection

Battery technology is a key component in current electric vehicle applications and an important building block for upcoming smart grid technologies. The performance of batteries depends largely on quality control during their production process. Defects introduced in the production of electrodes can lead to degraded performance and, more importantly, to short circuits in final cells, which is highly safety-critical. In this paper, we propose an inspection system architecture that can detect defects, such as missing coating, agglomerates, and pinholes on coated electrodes. Our system is able to acquire valuable production quality control metrics, like surface roughness. By employing photometric stereo techniques, a shape from shading algorithm, our system surmounts difficulties that arise while optically inspecting the black to dark gray battery coating materials. We present in detail the acquisition concept of the proposed system architecture, and analyze its acquisition-, as well as, its surface reconstruction performance in experiments. We carry these out utilizing two different implementations that can operate at a production speed of up to 2000 mm/s at a resolution of 50 µm per pixel. In this work we aim to provide a system architecture that can provide a reliable contribution to ensuring optimal performance of produced battery cells.

A Technical System for the Large-Scale Application of Metabolites From Paecilomyces variotii SJ1 in Agriculture

Compared with endophytes, metabolites from endophytes (MEs) have great potential in agriculture. However, a technique for industrializing the production of MEs is still scarce. Moreover, the establishment of effective methods for evaluating the quality of MEs is hampered by the fact that some compounds with beneficial effects on crops have not been clearly identified. Herein, a system was established for the production, quality control and application of MEs by using the extract from Paecilomyces variotii SJ1 (ZNC). First, the extraction conditions of ZNC were optimized through response surface methodology, after which each batch (500 L) met the consumption requirements of crops in 7,467 hectares. Then, chromatographic fingerprinting and enzyme-linked immunosorbent assay were applied to evaluate the similarity and specificity of unknown effective components in ZNC, ensuring a similarity of more than 90% and a quantitative accuracy of greater than 99.9% for the products from different batches. Finally, the bioactivity of industrially produced ZNC was evaluated in the field, and it significantly increased the potato yields by 4.4–10.8%. Overall, we have established a practical technical system for the large-scale application of ZNC in agriculture.

Improving Product Quality With Production Quality Control

PT. Z is a company engaged in the plastic bag industry. The company produces plastic bags, one of which is a type of ATP 12 x 24 that is often used as plastic wrapping meatballs, sugar and others. A company is certainly required to provide the best quality on its products. To meet the needs and expectations of consumers for the quality of products, the company must improve the quality of existing products. Six sigma is a quality tool that can be used to analyze and process data to maintain or improve the quality of a product based on the process. One of the shorts used in the six sigma method is Define, Measure, Analyze, Improve and Control ( DMAIC). This research focuses on the results of product defects produced for 5 months in 2019. Because of the process analyzed there is data of proportions that are out of control in july and november. So that the data is omitted so that the data can be controlled. The sigma production level of ATP 12 x 24 is currently at the level of 4 sigma so it is necessary to improve to reach the level of 6 sigma. Pareto diagrams and fishbone diagrams can be used as tools to analyze significant factors causing product defects. And it can be known that the causative factor that can be done repair is deflated.