Orthogonal organic and aqueous-based washes of tissue sections to enhance protein sensitivity by MALDI imaging mass spectrometry

2013 ◽  
Vol 48 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Aurélien Thomas ◽  
Nathan Heath Patterson ◽  
Jade Laveaux Charbonneau ◽  
Pierre Chaurand
Keyword(s):  
Mass Spectrometry ◽  
Imaging Mass Spectrometry ◽  
Maldi Imaging ◽  
Tissue Sections ◽  
Maldi Imaging Mass Spectrometry

Ionic Matrix for Enhanced MALDI Imaging Mass Spectrometry for Identification of Phospholipids in Mouse Liver and Cerebellum Tissue Sections

2010 ◽  
Vol 82 (21) ◽  
pp. 8800-8806 ◽  
Author(s):  
Kamlesh Shrivas ◽  
Takahiro Hayasaka ◽  
Naoko Goto-Inoue ◽  
Yuki Sugiura ◽  
Nobuhiro Zaima ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mouse Liver ◽  
Imaging Mass Spectrometry ◽  
Maldi Imaging ◽  
Tissue Sections ◽  
Maldi Imaging Mass Spectrometry ◽  
Ionic Matrix

scholarly journals Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections

2008 ◽  
Vol 19 (8) ◽  
pp. 1069-1077 ◽  
Author(s):  
Erin H. Seeley ◽  
Stacey R. Oppenheimer ◽  
Deming Mi ◽  
Pierre Chaurand ◽  
Richard M. Caprioli
Keyword(s):  
Mass Spectrometry ◽  
Chemical Treatment ◽  
Imaging Mass Spectrometry ◽  
Maldi Imaging ◽  
Tissue Sections ◽  
Maldi Imaging Mass Spectrometry

On the Importance of Mathematical Methods for Analysis of MALDI-Imaging Mass Spectrometry Data

2012 ◽  
Vol 9 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Dennis Trede ◽  
Jan Hendrik Kobarg ◽  
Janina Oetjen ◽  
Herbert Thiele ◽  
Peter Maass ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Imaging Mass Spectrometry ◽  
Mass Spectrometry Data ◽  
Maldi Imaging ◽  
Label Free ◽  
Imaging Data ◽  
Mathematical Methods ◽  
Data Set ◽  
Tissue Sections ◽  
Maldi Imaging Mass Spectrometry

Summary In the last decade, matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS), also called as MALDI-imaging, has proven its potential in proteomics and was successfully applied to various types of biomedical problems, in particular to histopathological label-free analysis of tissue sections. In histopathology, MALDI-imaging is used as a general analytic tool revealing the functional proteomic structure of tissue sections, and as a discovery tool for detecting new biomarkers discriminating a region annotated by an experienced histologist, in particular, for cancer studies.A typical MALDI-imaging data set contains 108 to 109 intensity values occupying more than 1 GB. Analysis and interpretation of such huge amount of data is a mathematically, statistically and computationally challenging problem. In this paper we overview some computational methods for analysis of MALDI-imaging data sets. We discuss the importance of data preprocessing, which typically includes normalization, baseline removal and peak picking, and hightlight the importance of image denoising when visualizing IMS data.

High-resolution MALDI imaging mass spectrometry allows localization of peptide distributions at cellular length scales in pituitary tissue sections

2007 ◽  
Vol 260 (2-3) ◽  
pp. 203-211 ◽  
Author(s):  
A.F. Maarten Altelaar ◽  
Ioana M. Taban ◽  
Liam A. McDonnell ◽  
Peter D.E.M. Verhaert ◽  
Robert P.J. de Lange ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Imaging Mass Spectrometry ◽  
Maldi Imaging ◽  
Length Scales ◽  
Tissue Sections ◽  
Pituitary Tissue ◽  
Maldi Imaging Mass Spectrometry

MALDI imaging mass spectrometry: an emerging tool in neurology

2021 ◽  
Author(s):  
Laura K. Schnackenberg ◽  
David A. Thorn ◽  
Dustyn Barnette ◽  
E. Ellen Jones
Keyword(s):  
Mass Spectrometry ◽  
Imaging Mass Spectrometry ◽  
Maldi Imaging ◽  
Maldi Imaging Mass Spectrometry

scholarly journals Region-specific bioconversion of dynorphin neuropeptide detected by in situ histochemistry and MALDI imaging mass spectrometry

Peptides ◽  
2017 ◽  
Vol 87 ◽  
pp. 20-27 ◽  
Author(s):  
Erik Bivehed ◽  
Robert Strömvall ◽  
Jonas Bergquist ◽  
Georgy Bakalkin ◽  
Malin Andersson
Keyword(s):  
Mass Spectrometry ◽  
Imaging Mass Spectrometry ◽  
Maldi Imaging ◽  
Maldi Imaging Mass Spectrometry

Analyte distributions in MALDI samples using MALDI imaging mass spectrometry

2009 ◽  
Vol 281 (1-2) ◽  
pp. 41-51 ◽  
Author(s):  
Hui Qiao ◽  
Gamini Piyadasa ◽  
Victor Spicer ◽  
Werner Ens
Keyword(s):  
Mass Spectrometry ◽  
Imaging Mass Spectrometry ◽  
Maldi Imaging ◽  
Maldi Imaging Mass Spectrometry
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