scholarly journals Effects of delayed treatment with combined GDNF and continuous electrical stimulation on spiral ganglion cell survival in deafened guinea pigs

2009 ◽  
Vol 87 (6) ◽  
pp. 1389-1399 ◽  
Author(s):  
Verena Scheper ◽  
Gerrit Paasche ◽  
Josef M. Miller ◽  
Athanasia Warnecke ◽  
Nurdanat Berkingali ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Ganglion Cell ◽  
Cell Survival ◽  
Guinea Pigs ◽  
Spiral Ganglion ◽  
Delayed Treatment ◽  
Spiral Ganglion Cell

Chronic electrical stimulation does not prevent spiral ganglion cell degeneration in deafened guinea pigs

2010 ◽  
Vol 269 (1-2) ◽  
pp. 169-179 ◽  
Author(s):  
Martijn J.H. Agterberg ◽  
Huib Versnel ◽  
John C.M.J. de Groot ◽  
Marloes van den Broek ◽  
Sjaak F.L. Klis
Keyword(s):  
Electrical Stimulation ◽  
Ganglion Cell ◽  
Guinea Pigs ◽  
Spiral Ganglion ◽  
Cell Degeneration ◽  
Spiral Ganglion Cell ◽  
Chronic Electrical Stimulation

scholarly journals Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss

1997 ◽  
Vol 15 (4-5) ◽  
pp. 631-643 ◽  
Author(s):  
Josef M. Miller ◽  
David H. Chi ◽  
Leonard J. O'Keeffe ◽  
Paul Kruszka ◽  
Yehoash Raphael ◽  
...  
Keyword(s):  
Hair Cell ◽  
Ganglion Cell ◽  
Cell Survival ◽  
Spiral Ganglion ◽  
Cell Loss ◽  
Hair Cell Loss ◽  
Inner Hair Cell ◽  
Spiral Ganglion Cell

Spiral ganglion cell morphology in guinea pigs after deafening and neurotrophic treatment

2013 ◽  
Vol 298 ◽  
pp. 17-26 ◽  
Author(s):  
Maarten C. van Loon ◽  
Dyan Ramekers ◽  
Martijn J.H. Agterberg ◽  
John C.M.J. de Groot ◽  
Wilko Grolman ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Cell Morphology ◽  
Guinea Pigs ◽  
Spiral Ganglion ◽  
Spiral Ganglion Cell

Electrocochleographic Changes in Endolymphatic Hydrops Induced by Type II Collagen Immunization through the Stylomastoid Foramen

1989 ◽  
Vol 98 (7) ◽  
pp. 556-562 ◽  
Author(s):  
Toru Ohashi ◽  
Koichi Tomoda ◽  
Nobuo Yoshie
Keyword(s):  
Ganglion Cell ◽  
Guinea Pigs ◽  
Endolymphatic Hydrops ◽  
Spiral Ganglion ◽  
Type Ii Collagen ◽  
Ménière’S Disease ◽  
Type Ii ◽  
Cell Degeneration ◽  
Stylomastoid Foramen ◽  
Spiral Ganglion Cell

Changes in action potential (AP) and summating potential (SP) were investigated in guinea pigs immunized with type II collagen through the stylomastoid foramen. Endolymphatic hydrops could be induced in four of 11 guinea pigs. The striking feature of the electrocochleographic waveform in guinea pigs with endolymphatic hydrops was the negative SP recording in response to high frequency tone bursts. Furthermore, abnormal changes in AP were observed in three of four hydropic guinea pigs. Morphologic study of the cochleas in these three guinea pigs with light microscopy revealed spiral ganglion cell degeneration in addition to endolymphatic hydrops and almost normal sensory hair cells. These results suggest that guinea pigs with hydrops as produced by our procedure can serve as a useful model of Meniere's disease, that autoimmune response may play an important role in the etiopathogenesis of Meniere's disease, and that spiral ganglion cell degeneration together with endolymphatic hydrops seems to contribute to abnormal changes in AP.

scholarly journals Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival

2014 ◽  
Vol 127 (5) ◽  
pp. 1138-1149 ◽  
Author(s):  
J. A. Coleman ◽  
X. Zhu ◽  
H. R. Djajadi ◽  
L. L. Molday ◽  
R. S. Smith ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Cell Survival ◽  
Spiral Ganglion ◽  
Auditory Function ◽  
Spiral Ganglion Cell ◽  
Phospholipid Flippase

Spiral ganglion cell survival after round window membrane application of brain-derived neurotrophic factor using gelfoam as carrier

2011 ◽  
Vol 272 (1-2) ◽  
pp. 168-177 ◽  
Author(s):  
Sarah Havenith ◽  
Huib Versnel ◽  
Martijn J.H. Agterberg ◽  
John C.M.J. de Groot ◽  
Robert-Jan Sedee ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Cell Survival ◽  
Neurotrophic Factor ◽  
Round Window ◽  
Spiral Ganglion ◽  
Brain Derived Neurotrophic Factor ◽  
Round Window Membrane ◽  
Spiral Ganglion Cell
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