scholarly journals Two‐step stem cell therapy improves bone regeneration compared to concentrated bone marrow therapy

2019 ◽  
Vol 37 (6) ◽  
pp. 1318-1328 ◽  
Author(s):  
Julia Bolte ◽  
Corina Vater ◽  
Anna Carla Culla ◽  
Tilman Ahlfeld ◽  
Jörg Nowotny ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Therapy ◽  
Bone Regeneration ◽  
Stem Cell Therapy ◽  
Concentrated Bone Marrow

Autologous bone marrow-derived stem cell therapy in heart disease: Discrepancies and contradictions

2013 ◽  
Vol 168 (4) ◽  
pp. 3381-3403 ◽  
Author(s):  
Darrel P. Francis ◽  
Michael Mielewczik ◽  
David Zargaran ◽  
Graham D. Cole
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Heart Disease ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Autologous Bone Marrow ◽  
Autologous Bone

The effect of bone marrow mononuclear stem cell therapy on left ventricular function and myocardial perfusion

2013 ◽  
Vol 21 (2) ◽  
pp. 351-367 ◽  
Author(s):  
Kamel Sadat ◽  
Sameer Ather ◽  
Wael Aljaroudi ◽  
Jaekyeong Heo ◽  
Ami E. Iskandrian ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Myocardial Perfusion ◽  
Cell Therapy ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Stem Cell Therapy ◽  
Left Ventricular

Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy

2012 ◽  
Vol 47 (5) ◽  
pp. 491-497 ◽  
Author(s):  
Shuji Terai ◽  
Haruko Tanimoto ◽  
Masaki Maeda ◽  
Junichi Zaitsu ◽  
Takuro Hisanaga ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Autologous Bone Marrow ◽  
Autologous Bone ◽  
Marrow Infusion ◽  
Bone Marrow Infusion

Stem cell therapy: A role for CXCR4 in homing bone marrow side population cells to areas of myocardial damage

2010 ◽  
Vol 145 (3) ◽  
pp. 554-555 ◽  
Author(s):  
Jenny Nilsson ◽  
Simi Ali ◽  
Ian Harvey ◽  
John A. Kirby ◽  
Annette P. Meeson
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Side Population ◽  
Myocardial Damage ◽  
Side Population Cells

scholarly journals Improving stem cell therapy in cardiovascular diseases: the potential role of microRNA

2016 ◽  
Vol 311 (1) ◽  
pp. H207-H218 ◽  
Author(s):  
Evelien Nollet ◽  
Vicky Y. Hoymans ◽  
Amaryllis H. Van Craenenbroeck ◽  
Christiaan J. Vrints ◽  
Emeline M. Van Craenenbroeck
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cardiovascular Diseases ◽  
Cell Therapy ◽  
Progenitor Cells ◽  
Stem Cell Therapy ◽  
Cell Function ◽  
Current Evidence ◽  
Comprehensive Overview ◽  
Vascular Regeneration

The initial promising prospect of autologous bone marrow-derived stem cell therapy in the setting of cardiovascular diseases has been overshadowed by functional shortcomings of the stem cell product. As powerful epigenetic regulators of (stem) cell function, microRNAs are valuable targets for novel therapeutic strategies. Indeed, modulation of specific miRNA expression could contribute to improved therapeutic efficacy of stem cell therapy. First, this review elaborates on the functional relevance of miRNA dysregulation in bone marrow-derived progenitor cells in different cardiovascular diseases. Next, we provide a comprehensive overview of the current evidence on the effect of specific miRNA modulation in several types of progenitor cells on cardiac and/or vascular regeneration. By elaborating on the cardioprotective regulation of progenitor cells on cardiac miRNAs, more insight in the underlying mechanisms of stem cell therapy is provided. Finally, some considerations are made regarding the potential of circulating miRNAs as regulators of the miRNA signature of progenitor cells in cardiovascular diseases.

Sign in / Sign up

Export Citation Format

Share Document