Assessment of Biliary Clearance in Early Drug Discovery using Sandwich-cultured Hepatocyte Model

Guoyu Pan; Carri Boiselle; Jianling Wang

doi:10.1002/jps.23070

Assessment of Biliary Clearance in Early Drug Discovery using Sandwich-cultured Hepatocyte Model

Journal of Pharmaceutical Sciences ◽

10.1002/jps.23070 ◽

2012 ◽

Vol 101 (5) ◽

pp. 1898-1908 ◽

Cited By ~ 18

Author(s):

Guoyu Pan ◽

Carri Boiselle ◽

Jianling Wang

Keyword(s):

Drug Discovery ◽

Biliary Clearance ◽

Cultured Hepatocyte ◽

Early Drug

A strategy to reduce biliary clearance in early drug discovery

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2013.03.003 ◽

2013 ◽

Vol 68 (3) ◽

pp. 346-348 ◽

Cited By ~ 1

Author(s):

Nathalie Rioux ◽

Edith Bellavance ◽

Hugo Poirier ◽

Mariève Dupuis ◽

Michel Garneau ◽

...

Keyword(s):

Drug Discovery ◽

Biliary Clearance ◽

Early Drug

High throughput P450 inhibition screens in early drug discovery

Drug Discovery Today ◽

10.1016/s1359-6446(05)03580-4 ◽

2005 ◽

Vol 10 (21) ◽

pp. 1443-1450 ◽

Cited By ~ 71

Author(s):

Gregor Zlokarnik ◽

Peter D.J. Grootenhuis ◽

John B. Watson

Keyword(s):

Drug Discovery ◽

High Throughput ◽

Early Drug

Strategic applications of toxicogenomics in early drug discovery

Current Opinion in Pharmacology ◽

10.1016/j.coph.2008.07.011 ◽

2008 ◽

Vol 8 (5) ◽

pp. 654-660 ◽

Cited By ~ 24

Author(s):

T RYAN ◽

J STEVENS ◽

C THOMAS

Keyword(s):

Drug Discovery ◽

Early Drug

Model-based Target Pharmacology Assessment (mTPA): An Approach Using PBPK/PD Modeling and Machine Learning to Design Medicinal Chemistry and DMPK Strategies in Early Drug Discovery

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c02033 ◽

2021 ◽

Vol 64 (6) ◽

pp. 3185-3196

Author(s):

Emile P. Chen ◽

Robert W. Bondi ◽

Paul J. Michalski

Keyword(s):

Machine Learning ◽

Drug Discovery ◽

Medicinal Chemistry ◽

Model Based ◽

Early Drug

Role of Bioinformatics in Early Drug Discovery: An Overview and Perspective

10.1002/9781119654803.ch3 ◽

2021 ◽

pp. 49-67

Author(s):

Shasank S. Swain ◽

Tahziba Hussain

Keyword(s):

Drug Discovery ◽

Early Drug

Application of Quantitative Biomeasures in Early Drug Discovery

Translating Molecular Biomarkers into Clinical Assays - AAPS Advances in the Pharmaceutical Sciences Series ◽

10.1007/978-3-319-40793-7_4 ◽

2016 ◽

pp. 37-46

Author(s):

Scott T. Fountain ◽

Paolo Vicini

Keyword(s):

Drug Discovery ◽

Early Drug

Physicochemical Proling in Early Drug Discovery: New Challenges at the Age of High-Throughput Screen and Combinatorial Chemistry

Chemistry and Molecular Aspects of Drug Design and Action ◽

10.1201/9781420008272-31 ◽

2008 ◽

pp. 325-334

Keyword(s):

Drug Discovery ◽

High Throughput ◽

Combinatorial Chemistry ◽

High Throughput Screen ◽

New Challenges ◽

Early Drug

Target Immobilization and NMR Screening of Fragments in Early Drug Discovery

Current Topics in Medicinal Chemistry ◽

10.2174/156802609790102400 ◽

2009 ◽

Vol 9 (18) ◽

pp. 1736-1745 ◽

Cited By ~ 12

Author(s):

Gregg Siegal ◽

Johan Hollander

Keyword(s):

Drug Discovery ◽

Nmr Screening ◽

Early Drug

Application of HPLC measurements for the determination of physicochemical and biomimetic properties to model in vivo drug distribution in support of early drug discovery

Handbook of Analytical Separations - Separation Methods in Drug Synthesis and Purification ◽

10.1016/b978-0-444-64070-3.00013-8 ◽

2020 ◽

pp. 667-758

Author(s):

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Keyword(s):

Drug Discovery ◽

Drug Distribution ◽

Early Drug

Next-Generation Phenotypic Screening in Early Drug Discovery for Infectious Diseases

Trends in Parasitology ◽

10.1016/j.pt.2019.05.004 ◽

2019 ◽

Vol 35 (7) ◽

pp. 559-570 ◽

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Author(s):

Nathalie Aulner ◽

Anne Danckaert ◽

JongEun Ihm ◽

David Shum ◽

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Keyword(s):

Drug Discovery ◽

Infectious Diseases ◽

Phenotypic Screening ◽

Next Generation ◽

Early Drug